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Corneal Surgery: From Innovation to Clinical Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 25 March 2026 | Viewed by 396

Special Issue Editor


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Guest Editor
Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany
Interests: keratoplasty; penetrating keratoplasty; DMEK; eye banking; corneal surgery

Special Issue Information

Dear Colleagues,

It is our pleasure to announce the upcoming Special Issue of the Journal of Clinical Medicine titled Corneal Surgery: From Innovation to Clinical Practice”.

Corneal surgery—especially lamellar keratoplasty—has become a routine procedure for many ophthalmologists. The growing popularity of these techniques requires comprehensive knowledge not only regarding eye banking and surgical methods but regarding postoperative care as well. Moreover, the recent advances in corneal surgery are genuinely astounding, ranging from novel biomaterials and synthetic materials to advanced laser platforms and innovative ophthalmic surgical techniques. The different subtypes of allogeneic corneal transplants show the ever-increasing use of a single-donor cornea for multiple procedures. The discovery of new biomaterials and the generation of tissues from well-known biologic components have contributed to newer medical and surgical management of corneal diseases. The improvements in laser platforms and their algorithms have led to more accurate and precise surgeries.

While some innovations fail in the clinical setting, there is still successes, as there will always be room for improvement in the preventive or curative aspects of clinical management. We invite cornea specialists, residents, general ophthalmologists, optometrists, clinical scientists in vision research, and those engaged in the biocompatible materials sciences to contribute articles to this Special Issue. We welcome retrospective and prospective studies and reviews on novel corneal surgeries, perioperative care and eye banking.

The quest to maintain and improve eye health as well as prevent eye disease is every eye professional’s goal. We invite you to contribute your studies in order to improve our collective understanding of innovative corneal biomaterials, platforms, and procedures for the benefit of our patients, the general public, medical practitioners, and eye health providers.

We look forward to receiving your contributions.

Dr. Joanna Wasielica-Poslednik
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • keratoplasty
  • penetrating keratoplasty
  • DMEK
  • eye banking
  • corneal surgery

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Published Papers (1 paper)

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Research

10 pages, 2016 KB  
Article
Impact of the Different Corneal Storage Flasks on Endothelial Cell Loss During Cultivation—A Retrospective Analysis
by Tarek Safi, Carolin Marion Kolb-Wetterau, Stephanie D. Grabitz, Francesco Buonfiglio, Melissa Apel and Joanna Wasielica-Poslednik
J. Clin. Med. 2025, 14(20), 7165; https://doi.org/10.3390/jcm14207165 - 11 Oct 2025
Viewed by 286
Abstract
Objectives: To evaluate the impact of different corneal storage containers—with and without corneal holders—on endothelial cell density (ECD) and endothelial cell loss (ECL) during organ culture, following a temporary shortage of Böhnke Donor Corneal Holders at a German eye bank. Methods: A retrospective [...] Read more.
Objectives: To evaluate the impact of different corneal storage containers—with and without corneal holders—on endothelial cell density (ECD) and endothelial cell loss (ECL) during organ culture, following a temporary shortage of Böhnke Donor Corneal Holders at a German eye bank. Methods: A retrospective analysis was conducted on 383 human donor corneas cultured in six types of containers between January and September 2024 at the Eye Bank of Rhineland-Palatinate. ECD was measured at 6.0 ± 1.2 days (ECD1) and again at 14.9 ± 4.4 days (ECD2) after retrieval using standardized organ culture protocols with an inverted light microscope. Group 1 (G1) used the standard 50 mL Corning® flask with the Böhnke corneal holder. Groups 2–6 used alternative containers, with or without corneal holders. ECL was defined as the difference between ECD2 and ECD1. Results: Mean overall ECD1 was 2478.3 ± 843.4 cells/mm2. G1 showed ECD1 < 2000 cells/mm2 in 29% of corneas and low ECL (−1%). The 60 mL Ratiolab® flask with Cornea-Claw® was the best alternative, showing the lowest incidence of ECD1 < 2000 cells/mm2 (7%) and no ECL. Containers without corneal holders, particularly the 100 mL Sterilin™ and 15 mL Cryogenic Tube®, had significantly higher rates of ECD1 < 2000 (40% and 75%) and greater ECL (9% and 14%). Conclusions: Container design, especially volume and the presence of corneal holders, significantly influences endothelial preservation. Especially a lack of corneal holders led to unacceptable endothelial cell loss. Eye banks should prioritize appropriate flask configurations to minimize tissue deterioration, particularly during supply shortages. Full article
(This article belongs to the Special Issue Corneal Surgery: From Innovation to Clinical Practice)
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