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Recent Advances in Prenatal Diagnosis and Maternal Fetal Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 March 2026 | Viewed by 1087

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy Carol Davila, Filantropia Clinical Hospital, Bucharest, Romania
Interests: obstetrics; materno fetal medicine; high-risk pregnancy; first-trimester screening; second-and third-trimester screening; prenatal diagnosis

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Guest Editor
Department Mother and Child, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: obstetrics; materno fetal medicine; high risk pregnancy; ultrasound; prenatal diagnosis
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Special Issue Information

Dear Colleagues,

Approximately 3% to 5% of pregnancies are complicated by fetal abnormalities, including genetic disorders and birth defects. The rate of preeclampsia in the world is estimated to range from 2% to 10% in healthy, nulliparous women. Prenatal diagnosis pertains to diagnosing fetal structural abnormalities, genetic and chromosomal diseases and pregnancy-related diseases before birth and to calculating risks for pregnancy complications. There are guidelines to calculate high-risk categories and to recommend prophylactic treatments. Advances in technology have led to the ability to diagnose more genetic conditions via chromosomal microarray analysis, whole-exome sequencing and next-generation sequencing. Advanced sonographic imaging and high-fidelity ultrasound equipment allow us to more precisely diagnose structural abnormalities, establish prognosis factors, treat intrauterine and recommend time for delivery and neonatal care.

Significant pre-existing medical disorders, such as cardiac, renal, hepatic or other diseases, increase the risk of maternal mortality and morbidity, pregnancy complications and adverse perinatal outcomes. Pre-pregnancy health, planning pregnancies, multidisciplinary teams and optimizing maternal health during pregnancy can have a positive impact on the mother and neonate.

The objective of this Special Issue is to present recent advances in the clinical medicine of prenatal diagnosis and maternal fetal medicine to acquire more knowledge and build confidence in daily practice.

 Topics will include the following:

  • Prenatal diagnosis;
  • Prenatal screening;
  • Fetal imaging;
  • Genetic syndromes;
  • Materno fetal medicine;
  • Intrauterine treatments;
  • High-risk pregnancy;

Dr. Anca Angela Simionescu
Prof. Dr. Ştefania Tudorache
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prenatal
  • obstetrics
  • fetal abnormalities
  • intrauterine treatments
  • genetic disorders
  • pregnancy

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Published Papers (1 paper)

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Review

27 pages, 918 KB  
Review
Optimizing Fetal Surveillance in Fetal Growth Restriction: A Narrative Review of the Role of the Computerized Cardiotocographic Assessment
by Bianca Mihaela Danciu and Anca Angela Simionescu
J. Clin. Med. 2025, 14(19), 7010; https://doi.org/10.3390/jcm14197010 - 3 Oct 2025
Viewed by 611
Abstract
Background/Objectives: Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Accurate surveillance and timely delivery are critical to improving outcomes. This narrative review examines the role of computerized cardiotocography (cCTG) and short-term variation (STV) interpretation in the monitoring of [...] Read more.
Background/Objectives: Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Accurate surveillance and timely delivery are critical to improving outcomes. This narrative review examines the role of computerized cardiotocography (cCTG) and short-term variation (STV) interpretation in the monitoring of FGR and its integration with Doppler velocimetry and the biophysical profile (BPP). Methods: A comprehensive literature search of PubMed, Scopus, and Web of Science was performed for studies published up to 2021 using combinations of terms related to FGR, CTG, STV, and Doppler surveillance. Eligible sources included original studies, systematic reviews, and international guidelines. Case reports, intrapartum-only monitoring, and studies involving major anomalies were excluded. Results: Reduced STV consistently correlates with fetal compromise, abnormal Doppler findings, and adverse perinatal outcomes. In early-onset FGR (<32 weeks), ductus venosus abnormalities often coincide with or precede STV reduction; combined use supports optimal timing of delivery. In late-onset FGR (≥32 weeks), STV changes are less pronounced and require integration with cerebroplacental ratio, variability indices, and trend-based interpretation. Longitudinal evaluation offers greater prognostic value than isolated measurements. However, heterogeneity in thresholds, fragmented outcome data, and system-specific definitions limit standardization and comparability across studies. Conclusions: cCTG provides an objective and adjunct to Doppler and BPP in the surveillance of FGR, a tool for obstetrician needs. Its greatest utility lies in serial, integrated assessment, supported by gestational age-specific reference ranges. Future advances should include standardized STV thresholds, large outcome-linked databases, and artificial intelligence-driven tools to refine decision-making and optimize delivery timing. Full article
(This article belongs to the Special Issue Recent Advances in Prenatal Diagnosis and Maternal Fetal Medicine)
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