Current Concepts in Prostate Cancer: From Early Detection to Therapeutic Innovations

Dear Colleagues,

Prostate cancer remains one of the most frequently diagnosed malignancies in men and a leading cause of cancer-related morbidity and mortality worldwide. Recent advances in screening strategies, multiparametric imaging, molecular and genomic profiling, and clinical risk stratification tools have refined early detection and enabled more personalized clinical decision-making. In parallel, progress in focal therapies, image-guided and adaptive radiotherapy, novel systemic treatments, and minimally invasive and robotic surgical techniques is reshaping the management of both localized and advanced disease.

This Special Issue aims to provide a comprehensive, up-to-date overview of current concepts and therapeutic innovations in prostate cancer care, spanning the disease continuum from early detection through long-term follow-up and survivorship. Topics of interest include early detection and screening strategies, active surveillance and risk-adapted management, imaging-guided diagnosis and staging, treatment selection and sequencing, management of treatment-related toxicity and functional outcomes, and long-term oncological and patient-reported outcomes.

Particular emphasis is placed on evidence-based clinical practice, translational research, and technological and methodological innovations that improve survival, functional outcomes, and quality of life.

We welcome original research and clinical reviews that highlight emerging therapies and evolving standards of care in prostate cancer management.

Dr. Alessio Paladini
Dr. Giovanni Cochetti
Dr. Igor Duquesne
Guest Editors

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