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Latest Advances in Ocular Surface Diseases
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Latest Advances in Ocular Surface Diseases

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Ophthalmology".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 1996

Editor

Dr. Barbara Burgos-Blasco

E-Mail Website
Guest Editor
Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), 28040 Madrid, Spain
Interests: cataract surgery; corneal diseases; corneal topography; phacoemulsification; cataract extraction; cornea bankinge
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ocular surface diseases (OSD) are a group of conditions that affect the outermost layers of the eye and range from mild forms of keratoconjunctivitis sicca to severe conditions, including conjunctival diseases, corneal diseases, dry eye disease, ocular herpes, and other infections. Current concepts and emerging treatments for OSD aim to improve cures, control symptoms, and prevent worsening of the disease. Moreover, emerging strategies for the treatment of OSD hold great promise in improving patient outcomes. However, several challenges remain in the diagnosis and treatment of OSD, including the lack of standardized diagnostic tests and the difficulty in monitoring disease progression.

We invite researchers to submit original research and review articles on advanced treatments for the management of cornea and ocular surface diseases.

Dr. Barbara Burgos-Blasco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cornea
  • keratitis
  • ocular surface disease
  • dry eye
  • corneal ulcer
  • keratoplasty
  • conjunctival disease

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Published Papers (2 papers)

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Research

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14 pages, 6217 KB  
Article
A Multimodal Analysis of Serum and Tear Crystallization Patterns in Patients with Obesity
by Cosmin Victor Ganea, Anisia Iuliana Alexa, Nicoleta Anton, Calina Anda Sandu, Madalina Ioana Bilha, Vlad Constantin Donica, Irina Andreea Pavel, Roxana Elena Ciuntu and Camelia Margareta Bogdanici
J. Clin. Med. 2026, 15(2), 773; https://doi.org/10.3390/jcm15020773 - 17 Jan 2026
Cited by 2 | Viewed by 715
Abstract
Objectives: The study examined tear and serum alterations using the ferning test and quantified the number of branches formed during the controlled drying of these biological fluids (tears and serum), in order to identify a potential diagnostic patterning test in individuals with [...] Read more.
Objectives: The study examined tear and serum alterations using the ferning test and quantified the number of branches formed during the controlled drying of these biological fluids (tears and serum), in order to identify a potential diagnostic patterning test in individuals with obesity. Methods: A total of 61 patients aged between 25 and 72 years were enrolled (median age [interquartile range] = 39.0 [26] years). BMI values ranged from 19.1 to 47.5 kg/m2, with a median BMI (interquartile range) of 29.3 (12.1) kg/m2. Results: The Kruskal–Wallis test showed statistically significant differences among at least two Schirmer classes with respect to the number of branches observed in dried tears at a brightness threshold of 220 (H(2) = 8.485, p = 0.014). According to the Dunn post hoc test, Schirmer Class 1 showed a markedly lower number of branches compared with Classes 2 and 3 (p < 0.031 and p < 0.021), whereas no significant difference was found between Classes 2 and 3. The Kruskal–Wallis test further suggested the presence of statistically significant differences in the number of branches in dried serum, quantified using ImageJ2 at a brightness threshold of 190, across visceral fat classes (H(2) = 9.583, p = 0.008). Dunn’s post hoc tests revealed that the number of branches in serum analyzed at a brightness threshold of 190 was significantly higher in visceral fat class 3 compared to class 1 (pholm = 0.006), while no statistically significant differences were observed between classes 1 and 2 or between classes 2 and 3 (pholm > 0.05). Conclusions: In addition to other obesity-specific complications patients with obesity exhibit an increased risk of developing dry eye syndrome. The combined assessment of DPT in both the tear film and serum may represent a new method for analyzing obesity-associated biomarkers. Further studies are required to determine the sensitivity and specificity of these approaches in diagnosing systemic alterations induced by excess adipose tissue. Full article
(This article belongs to the Special Issue Latest Advances in Ocular Surface Diseases)
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Other

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16 pages, 1084 KB  
Systematic Review
Lipid Layer Thickness in Soft Contact Lens Wearers With and Without Lenses In Situ—A Systematic Review and Meta-Analysis
by Maria Sobol and Jacek Pniewski
J. Clin. Med. 2026, 15(3), 1110; https://doi.org/10.3390/jcm15031110 - 30 Jan 2026
Viewed by 679
Abstract
Objectives: To systematically review and quantitatively synthesize lipid layer thickness (LLT) measurements in soft contact lens (CL) wearers obtained in the presence and absence of contact lenses in situ. Methods: A systematic literature search of PubMed, Scopus, and Web of Science databases was [...] Read more.
Objectives: To systematically review and quantitatively synthesize lipid layer thickness (LLT) measurements in soft contact lens (CL) wearers obtained in the presence and absence of contact lenses in situ. Methods: A systematic literature search of PubMed, Scopus, and Web of Science databases was conducted in accordance with PRISMA guidelines. Six studies meeting predefined inclusion criteria were included. Pooled mean LLT values were calculated using fixed-effects models, with heterogeneity, sensitivity analyses, and publication bias assessed. Results: In the absence of contact lenses, pooled LLT data from 86 healthy CL wearers yielded a mean LLT of 62.11 nm (95% CI: 47.33–76.90 nm). In the presence of contact lenses, pooled data from 330 subjects demonstrated a mean LLT of 69.52 nm (95% CI: 56.33–82.70 nm). Although LLT values were numerically higher with contact lens wear, the substantial overlap of confidence intervals indicated no consistent or statistically demonstrable difference between conditions. Conclusions: This meta-analysis provides the first quantitative synthesis of LLT in CL wearers and highlights the need for standardized methodologies to clarify the clinical relevance of LLT in contact lens-related tear film assessment. Full article
(This article belongs to the Special Issue Latest Advances in Ocular Surface Diseases)
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