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New Insights into Acne Vulgaris Treatment and Management Strategies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 650

Special Issue Editor


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Guest Editor
UOC Clinical and Corrective Dermatology, IDI-IRCCS, Via Dei Monti di Creta 104, 00167 Rome, Italy
Interests: dermocosmetology; pediatric and developmental dermatology; atopic dermatitis; acne and pathologies of the pilosebaceous unit; autoimmune bullous diseases

Special Issue Information

Dear Colleagues,

This Special Issue aims at providing a comprehensive overview on new and emerging topics about acne vulgaris treatment and management. This common dermatologic condition is burdened by negative impact on the quality of life of patients.

Advances in acne pathogenesis comprehension have been made, and numerous treatment strategies have been proposed. Despite this, the complexity of its pathogenesis and the variety of clinical presentations and emerging clinical scenarios impose a continuous need for new treatment modalities and therapeutic schemes.

Researchers, clinicians, and experts in this field are invited to contribute with original research articles, reviews, and clinical studies that provide new and interesting acquisitions on acne treatment and management modalities.

This Special Issue aims at covering a wide range of topics, including, but not limited to, the following:

  1. New therapeutic schemes and prescription modalities of isotretinoin treatment;
  2. New advances and critical aspects of the use of systemic antibiotics;
  3. Advances in hormonal treatment;
  4. Managing acne in athletes;
  5. Impact on lifestyle modifications on disease course and management;
  6. The role and real effectiveness of non-pharmacological therapies and “acneceuticals”;
  7. Use of isotretinoin in combination with energy-based devices;
  8. New techniques and protocols for acne scar treatment.

We welcome original research articles, comprehensive reviews, and meta-analyses that provide valuable insights into the targeted treatment of skin inflammation. However, please note that this Special Issue will not consider mini-reviews or case reports.

We look forward to receiving your contributions and thank you for your support.

Dr. Jo Linda Maria Sinagra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acne
  • hormonal treatments
  • isotretinoin
  • laser therapy
  • antibiotic

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Published Papers (1 paper)

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Research

15 pages, 3892 KB  
Article
Cosmetic Benefits of Medium-Depth Chemical Peels for Moderate Acne Lesions and Atrophic Acne Scars: A Single-Arm Clinical Trial in Young Adults
by Anna Deda, Magdalena Hartman-Petrycka, Marta Gędoś, Martyna Wojciechowska and Dominika Wcisło-Dziadecka
J. Clin. Med. 2025, 14(23), 8598; https://doi.org/10.3390/jcm14238598 - 4 Dec 2025
Viewed by 333
Abstract
Background: Acne vulgaris is a common inflammatory disorder with significant clinical and psychosocial impacts. Medium-depth chemical peels are increasingly used to manage both active acne lesions and atrophic acne scars. This study aimed to quantitatively assess the clinical effectiveness of a novel multimodal [...] Read more.
Background: Acne vulgaris is a common inflammatory disorder with significant clinical and psychosocial impacts. Medium-depth chemical peels are increasingly used to manage both active acne lesions and atrophic acne scars. This study aimed to quantitatively assess the clinical effectiveness of a novel multimodal medium-depth chemical peel regimen, yellow peel, in improving acne severity and scar depth, as well as skin hydration and sebum production in patients with mild to moderate facial acne. Methods: Twenty patients (17 women and 3 men) aged 20–25 with mild to moderate acne vulgaris underwent two sessions of yellow peel treatment at four-week intervals. The peel protocol combined glycolic acid, salicylic acid, and a multi-acid mask containing retinol, azelaic, phytic, kojic, and salicylic acids. Clinical outcomes were evaluated at baseline, four weeks after the first peel, and two months after the second peel. Assessments included the Investigators Global Assessment (IGA), inflammatory lesion count, 3D scar depth analysis, skin hydration (corneometer), and sebum secretion (sebumeter). Results: Yellow peel treatment significantly reduced acne severity, with an 85% decrease in inflammatory lesion counts and over 20% reduction in scar depth. Skin hydration improved significantly across all facial regions, and sebum secretion decreased substantially, enhancing skin barrier function and seboregulation. Statistical analysis confirmed the treatment’s efficacy with sustained improvements two months post-final peel. Conclusions: The yellow peel protocol is an effective and well-tolerated adjunct therapy for managing mild to moderate acne and atrophic acne scars. By combining exfoliative, anti-inflammatory, antibacterial, sebostatic, and depigmenting agents, this multimodal approach delivers comprehensive skin improvement. Further large-scale, controlled studies are recommended to confirm long-term safety and efficacy. Full article
(This article belongs to the Special Issue New Insights into Acne Vulgaris Treatment and Management Strategies)
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