Periodontitis and Systemic Health: Exploring the Oral-Systemic Connection
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 2
Special Issue Editors
Interests: periodontology; periodontal disease; periodontal medicine
Special Issue Information
Dear Colleagues,
Periodontitis has long been viewed as a localized oral chronic inflammatory disease. However, emerging evidence is highlighting its broader implications for systemic health, reinforcing the concept of an intricate oral–systemic connection. This relationship is grounded in the inflammatory pathways and microbial dissemination that link periodontal pathology with several chronic non-communicative diseases and conditions, such as cardiovascular disease, diabetes mellitus, and adverse pregnancy outcomes. However, there are also data emerging in relation to Alzheimer’s disease, obesity, auto-immune conditions, certain cancers, respiratory diseases, and chronic kidney disease.
The implications for clinical practice are profound. Interdisciplinary collaboration between dental professionals and medical practitioners is vital in ensuring the early identification and management of periodontitis, particularly in patients with systemic risk profiles. Preventive strategies, patient education, and regular periodontal maintenance may contribute not only to oral health but also to a reduction in systemic disease burden.
As our understanding of the oral–systemic axis deepens, it is clearly imperative to view periodontal health as an integral component of holistic patient care. Future research should continue to elucidate causal mechanisms, refine therapeutic strategies, and ultimately, improve patient outcomes across medical disciplines.
The purpose of this Special Issue is to showcase recent studies exploring the oral–systemic connection.
Dr. Yiorgos Bobetsis
Prof. Dr. Phoebus Madianos
Guest Editors
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Keywords
- periodontal disease
- systemic diseases
- cardiovascular disease
- diabetes mellitus
- adverse pregnancy outcomes
- respiratory disease
- neurodegenerative disorders
- obesity
- respiratory diseases
- chronic kidney disease
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