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Contemporary Trends in Cardiovascular Prevention

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 March 2026 | Viewed by 112

Special Issue Editors


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Guest Editor
Interventional and Clinical Cardiology Unit, Policlinico San Marco, 24040 Zingonia, Italy
Interests: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor Assistant
Interventional and Clinical Cardiology Unit, Policlinico San Marco, 24040 Zingonia, Italy
Interests: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia

Special Issue Information

Dear Colleagues,

Cardiovascular diseases represent the leading cause of death globally, posing a major challenge to public health systems and affecting millions of individuals each year. In this context, the need to develop and implement effective prevention strategies is more urgent than ever. The continuous evolution of diagnostic tools, risk assessment models, and therapeutic approaches has opened up new scenarios for both primary and secondary prevention.

This Special Issue is dedicated to exploring the latest advancements in cardiovascular prevention, with a particular focus on emerging technologies, evidence-based interventions, and integrated care pathways. We invite contributions that can enrich the current understanding of preventive cardiology and support its translation into everyday clinical practice.

Dr. Alessandro Durante
Guest Editor

Dr. Alessandro Mazzapicchi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interventional cardiology
  • coronary artery disease
  • carotid artery disease
  • aortic valve disease
  • left atrial appendage closure
  • hypercholesterolemia

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Published Papers (1 paper)

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18 pages, 688 KB  
Systematic Review
Impact of Nicotine-Free Electronic Cigarettes on Cardiovascular Health: A Systematic Review
by Ivana Jukic, Tina Becic, Ivona Matulic, Petra Simac and Jonatan Vukovic
J. Clin. Med. 2025, 14(24), 8717; https://doi.org/10.3390/jcm14248717 - 9 Dec 2025
Abstract
Background: The cardiovascular effects of nicotine-containing e-cigarettes are well-established; however, far less is known about nicotine-free formulations, which are often perceived as safer alternatives. Yet, these products generate complex aerosols that may still pose toxicological risks. Methods: Following the PRISMA 2020 [...] Read more.
Background: The cardiovascular effects of nicotine-containing e-cigarettes are well-established; however, far less is known about nicotine-free formulations, which are often perceived as safer alternatives. Yet, these products generate complex aerosols that may still pose toxicological risks. Methods: Following the PRISMA 2020 guidelines, we systematically searched PubMed, Scopus, Web of Science, and the Cochrane Library up to 27 August 2025. Eligible studies included human and animal research on nicotine-free e-cigarettes evaluating vascular, hemodynamic, arrhythmic, oxidative, or inflammatory outcomes. Owing to the heterogeneity of the studies, the findings were synthesized qualitatively. Results: Nine studies met the inclusion criteria. Human trials consistently demonstrated acute vascular impairments, including endothelial dysfunction, oxidative stress, increased arterial stiffness, and transient blood pressure elevations. Experimental models corroborated these findings and further revealed systemic inflammation, mitochondrial injury, and developmental cardiotoxicity. Conclusions: Nicotine-free e-cigarettes produce reproducible acute cardiovascular effects. Although the long-term outcomes remain uncertain, preclinical evidence highlights biologically plausible mechanisms, including mitochondrial dysfunction and proarrhythmogenic potential. Until large-scale longitudinal studies have been conducted to clarify their risk profile, nicotine-free products should not be regarded as risk-free. Full article
(This article belongs to the Special Issue Contemporary Trends in Cardiovascular Prevention)
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