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Advances in the Clinical Management of Pregnancy-Related Complications
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Advances in the Clinical Management of Pregnancy-Related Complications

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 22 September 2026 | Viewed by 1385

Editor

Dr. Panagiotis Peitsidis

E-Mail Website
Guest Editor
Fifth Department of Obstetrics and Gynecology, Elena Venizelou Maternity Hospital, 11521 Athens, Greece
Interests: fetal medicine; hysteroscopy; laparoscopy; colposcopy; gynecological surgery; gynecological ultrasound
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pregnancy-related complications are serious clinical issues that challenge many medical specialists. A multidisciplinary, systematic approach is required to tackle these challenging tasks. The progress in diagnosis and management is dependent on various parameters and is different in various resource settings. In this current Special Issue, which is the successful continuation of two previous Special Issues, we will try to discuss and analyze in detail the advances in the management of pregnancy-related complications. Crucial clinical problems such as hypertension, diabetes, preterm labor, placenta accreta spectrum, infections, and others will be reported. Special focus will be given to contemporary advances in the management of these clinical situations. All types of articles are welcome, especially articles and reviews.

Dr. Panagiotis Peitsidis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy
  • complications
  • hypertension
  • diabetes
  • placenta accreta
  • preterm labor
  • infections

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Published Papers (2 papers)

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Research

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12 pages, 466 KB  
Article
Intrapartum Febrile Morbidity and Maternal Birth Trauma After Vaginal Delivery: A Parity-Stratified Retrospective Cohort Study
by Eiman Shalabna, Amy Goh, Deepa Gopinath, Chen Nahshon, Esther Maor-Sagie and Rinat Gabbay-Benziv
J. Clin. Med. 2026, 15(16), 6220; https://doi.org/10.3390/jcm15166220 - 11 Aug 2026
Viewed by 280
Abstract
Objective: We aimed to evaluate the association between intrapartum febrile morbidity and maternal birth trauma among women undergoing vaginal delivery, with stratification by parity. Methods: This retrospective cohort study included women with singleton, cephalic, vaginal deliveries at a university-affiliated medical center between 2018 [...] Read more.
Objective: We aimed to evaluate the association between intrapartum febrile morbidity and maternal birth trauma among women undergoing vaginal delivery, with stratification by parity. Methods: This retrospective cohort study included women with singleton, cephalic, vaginal deliveries at a university-affiliated medical center between 2018 and 2024, excluding multiple gestations and cesarean deliveries. The primary exposure was intrapartum febrile morbidity, defined as maternal intrapartum temperature ≥38.0 °C, with or without clinical chorioamnionitis. The primary outcome was maternal birth trauma, including first- through fourth-degree perineal lacerations, cervical lacerations, or episiotomy. Multivariable logistic regression models were used to assess the independent association between intrapartum febrile morbidity and birth trauma. Analyses were additionally stratified by parity. Results: Among 21,736 women with vaginal deliveries included in the study, birth trauma occurred in 41.8% of deliveries (9075/21,736). Intrapartum febrile morbidity was more common among women with birth trauma compared with those delivering with an intact perineum (4.2% vs. 1.8%, p < 0.001). After adjustment for confounders, intrapartum febrile morbidity remained independently associated with birth trauma in the overall cohort (adjusted odds ratio [aOR], 1.5; 95% CI, 1.1–1.8). In parity-stratified analyses, the association persisted among multiparous women (aOR 1.8; 95% CI, 1.2–2.9) but was not statistically significant among nulliparous women (aOR, 1.3; 95% CI, 0.9–1.7). Nulliparity and operative vaginal delivery were the strongest predictors of birth trauma. Conclusions: These findings suggest that intrapartum febrile morbidity may identify women at increased risk of lower genital tract trauma beyond established mechanical risk factors. Full article
(This article belongs to the Special Issue Advances in the Clinical Management of Pregnancy-Related Complications)
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20 pages, 2064 KB  
Systematic Review
Assessment of Abdominal Aorta Balloon Occlusion Efficiency and Safety in Patients with Placenta Accreta Spectrum Disorder: A Systematic Review and Meta-Analysis
by Meruyert Abdukassimova, Gulzhanat Aimagambetova, Milan Terzic, Altynshash Rakhat, Karlygash Togyzbayeva, Lyazzat Saidildina and Gauri Bapayeva
J. Clin. Med. 2026, 15(9), 3400; https://doi.org/10.3390/jcm15093400 - 29 Apr 2026
Viewed by 573
Abstract
Background/Objectives: Placenta accreta spectrum (PAS) disorders are a major cause of life-threatening obstetric hemorrhage and frequently necessitate cesarean hysterectomy. Abdominal aorta balloon occlusion (AABO) has been increasingly adopted as a strategy to reduce intraoperative blood loss during cesarean section. This study aims [...] Read more.
Background/Objectives: Placenta accreta spectrum (PAS) disorders are a major cause of life-threatening obstetric hemorrhage and frequently necessitate cesarean hysterectomy. Abdominal aorta balloon occlusion (AABO) has been increasingly adopted as a strategy to reduce intraoperative blood loss during cesarean section. This study aims to evaluate the effectiveness and safety of AABO during cesarean delivery in women with PAS disorders. Materials and Methods: A systematic review and meta-analysis of studies published in English from 2015 to April 2025 was conducted using the following databases: Embase, Scopus, PubMed, Google Scholar, and Web of Science. Articles that met inclusion criteria focused on human participants, original studies, female participants, and studied the efficacy of AABO on blood loss during cesarean delivery for PAS. Articles that were reviews, case reports, other occlusion procedures, and animal studies were excluded. Risk of bias was evaluated using the Newcastle-Ottawa Scale. Results: Twenty-four studies comprising 1958 cesarean deliveries with AABO and 1791 without AABO met the inclusion criteria. Data on blood loss, transfusion, hysterectomy, maternal complications, and neonatal outcomes were extracted, synthesized, and analyzed. The majority of studies (91.6%) applied the balloon at the infrarenal level. Cesarean delivery with AABO resulted in substantially lower mean blood loss (1231 ± 688 mL vs. 2253 ± 857 mL, p < 0.001) and reduced requirements for blood transfusion compared with cesarean delivery alone. Hysterectomy rates were threefold lower with AABO (7.8% vs. 25.8%, p < 0.001), and the incidence of hemorrhagic shock and re-laparotomy were markedly reduced. Complications associated with AABO, including lower limb arterial thrombosis and fever, were uncommon and generally manageable. Conclusions: AABO during cesarean delivery for PAS disorders is associated with reduced intraoperative blood loss, lower transfusion requirements, and decreased hysterectomy rates, suggesting improved maternal hemodynamic stability. Although the procedure is generally safe, vigilance for vascular and thromboembolic complications is essential, and preventive strategies should be incorporated into perioperative care. These findings support the integration of AABO into multidisciplinary management protocols for women with PAS disorders. Future randomized prospective studies should be performed to improve patient selection criteria, standardize the protocols, and further evaluate the long-term maternal and neonatal safety/outcomes of the procedure. Full article
(This article belongs to the Special Issue Advances in the Clinical Management of Pregnancy-Related Complications)
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