Current Advances and Future Perspectives of Sepsis and Septic Shock
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Emergency Medicine".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 26
Special Issue Editors
Interests: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication
Special Issue Information
Dear Colleagues,
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Patients with septic shock can be identified as having sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure above 65 mmHg and having a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation.
The incidence of sepsis has increased, probably due to the progressive aging of the population, as several studies have demonstrated a relationship between age and incidence of sepsis and a larger number of people with disease comorbidities. Different studies have demonstrated a decrease in mortality related to sepsis over the years. Some possible reasons are improvements in diagnostic procedures, earlier and broader-spectrum antibiotic treatment, or more aggressive supportive therapy. In spite of the reduction in mortality, the absolute number of patients that die as a result of sepsis is increasing, resulting in more than 5 million deaths globally each year, consequently making it a major public health concern. As a result, novel therapeutic interventions for sepsis have been explored over the last several decades with inconsistent benefits.
Sepsis continues to be the primary cause of death from infection, and early recognition and appropriate treatment are required to improve outcomes.
Therefore, this Special Issue of the Journal of Clinical Medicine aims to publish contributions from distinguished authors who actively experience innovations in the field of sepsis and septic shock and want to provide more solid scientific evidence. We welcome all original works and reviews (please note that case reports and short reviews are not accepted).
Dr. Filippo Mearelli
Prof. Dr. Gianni Biolo
Guest Editors
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Keywords
- sepsis
- epidemiology
- biomarkers
- diagnosis
- predictive models
- prognostication
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