Current Advances and Future Perspectives of Sepsis and Septic Shock
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Emergency Medicine".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 12
Special Issue Editors
Interests: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication
Special Issue Information
Dear Colleagues,
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Patients with septic shock can be identified as having sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure above 65 mmHg and having a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation.
The incidence of sepsis has increased, probably due to the progressive aging of the population, as several studies have demonstrated a relationship between age and incidence of sepsis and a larger number of people with disease comorbidities. Different studies have demonstrated a decrease in mortality related to sepsis over the years. Some possible reasons are improvements in diagnostic procedures, earlier and broader-spectrum antibiotic treatment, or more aggressive supportive therapy. In spite of the reduction in mortality, the absolute number of patients that die as a result of sepsis is increasing, resulting in more than 5 million deaths globally each year, consequently making it a major public health concern. As a result, novel therapeutic interventions for sepsis have been explored over the last several decades with inconsistent benefits.
Sepsis continues to be the primary cause of death from infection, and early recognition and appropriate treatment are required to improve outcomes.
Therefore, this Special Issue of the Journal of Clinical Medicine aims to publish contributions from distinguished authors who actively experience innovations in the field of sepsis and septic shock and want to provide more solid scientific evidence. We welcome all original works and reviews (please note that case reports and short reviews are not accepted).
Dr. Filippo Mearelli
Prof. Dr. Gianni Biolo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sepsis
- epidemiology
- biomarkers
- diagnosis
- predictive models
- prognostication
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
