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Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 475

Special Issue Editor


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Guest Editor
1. Colorectal Surgery Unit, General Surgery Department, Hospital Universitario de la Princesa, Madrid, Spain
2. Colorectal Surgery Department, Clínica Santa Elena, 28003 Madrid, Spain
Interests: oncology; colorectal cancer; rectal cancer organ preservation; proctology; inflammatory bowel disease; functional disorders; fecal incontinence; minimally invasive surgery; robotic surgery; enhanced recovery after surgery; surgery prehabilitation
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Special Issue Information

Dear Colleagues,

Following on from the success of our first Special Issue, entitled “Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation” (https://www.mdpi.com/journal/jcm/special_issues/LHUCW4DOZ2), we are launching a second edition, which continues to report on clinical research.

The field of perioperative care has undergone a real revolution over the last 25 years. First, the rapid spread of enhanced perioperative recovery pathways, and later, the spread of prehabilitation, have revolutionized the rules of management of patients scheduled for surgery. Despite this, the implementation of such strategies in many centers is suboptimal, and there are still many issues on which evidence is lacking.

The aim of this Special Issue is to serve as a forum to critically address the most relevant and, above all, some of the most unexplored aspects of perioperative medicine, from education, strategies for implementation, maintenance, possible areas for future improvement, and, most importantly, the long-term outcomes and patient-reported outcome measures.

Priority is given to high-quality, original studies, but well-designed and conducted systematic reviews (with or without a meta-analysis) are welcome. In summary, the Special Issue aims to increase clinicians’ knowledge of poorly explored areas of perioperative care, as well as to provide a balanced, sound, and evidence-based overview of the advances and potential perspectives in the field.

Dr. Carlos Cerdán Santacruz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • perioperative care
  • enhanced recovery after surgery
  • prehabilitation
  • minimally invasive surgery
  • patient-related outcome measures
  • colorectal surgery
  • general surgery
  • thoracic surgery
  • vascular surgery
  • optimal functional recovery

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Published Papers (1 paper)

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16 pages, 1017 KB  
Perspective
Prehabilitation: A Catalyst for Transforming Toward Value-Based, Personalized Perioperative Health and Care
by Brenda H. van Koningsveld-Couperus, Thijs de Rooij, Nico L. van Meeteren, Benedikt Preckel, Markus W. Hollmann and Gertrude J. Nieuwenhuijs-Moeke
J. Clin. Med. 2025, 14(19), 6747; https://doi.org/10.3390/jcm14196747 - 24 Sep 2025
Viewed by 384
Abstract
The growing strain on global healthcare systems, driven by aging populations, rising prevalence of chronic diseases, and workforce shortages, has increased interest in strategies that enhance perioperative outcomes and healthcare sustainability. From this perspective, prehabilitation—a proactive, multimodal approach to enhance patients’ functional, nutritional, [...] Read more.
The growing strain on global healthcare systems, driven by aging populations, rising prevalence of chronic diseases, and workforce shortages, has increased interest in strategies that enhance perioperative outcomes and healthcare sustainability. From this perspective, prehabilitation—a proactive, multimodal approach to enhance patients’ functional, nutritional, and psychological status prior to surgery—has gained attention as a potential contributor to value-based, personalized care. This study aims to synthesize mechanistic rationale, clinical evidence, and system-level considerations for prehabilitation, with particular focus on allostatic capacity and the body’s response to surgical stress. Current evidence shows that prehabilitation may reduce postoperative complications, shorten hospital stays, and improve functional recovery, particularly when interventions are multimodal. However, the existing literature is characterized by methodological heterogeneity and variable quality, seemingly limiting generalizability and large-scale implementation. Further research is required to standardize outcome measures, identify patient subgroups most likely to benefit, and evaluate cost-effectiveness. Integration of prehabilitation into perioperative care pathways will depend on improved mechanistic understanding, robust clinical trials, and alignment with broader health policy and system-level initiatives. Prehabilitation may represent a meaningful step toward value-based and sustainable surgical care, though its implementation must be guided by high-quality evidence and careful consideration of context-specific factors. Full article
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