Clinical Insights and Advances in Structural Heart Disease
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 19
Special Issue Editor
Special Issue Information
Dear Colleagues,
Over the last 20 years, structural cardiac intervention procedures have grown exponentially. Research continues at a fast pace and we wish to inform the readership of the treatment options that are now available. The indications for TAVR are continuing to expand, with recent trials showing at least equivalence to surgical aortic valve replacement (SAVR) in lower-risk patients at follow-up. The concept of a ‘valve for life’ is increasingly important. Self-expanding valves appear to show better haemodynamic function to balloon expandable valves in patients requiring a smaller size TAVR. The use of Valve-in-Valve TAVR (for degenerative SAVR and TAVR) also continues to increase, with follow-up reported in clinical trials and registries. Para-valvular regurgitation still occurs following TAVI and further structural intervention is challenging, usually involving detailed transoesophageal imaging and the use of one or more vascular plug devices.
There are several different percutaneous devices for functional mitral and tricuspid regurgitation available. Trials evaluating percutaneous edge-to-edge repair for mitral regurgitation show clinical benefit beyond 5 years. Tricuspid valve procedures are more complex, but early trial results show clinical benefit in carefully selected patients. Trials evaluating percutaneous left atrial appendage occlusion devices show that they reduce stroke rates in patients with atrial fibrillation who have contra-indication to oral anticoagulation, while recent trials of PFO occluder devices appear to show benefit in carefully selected patients over 60 years of age by preventing recurrent stroke. In this Special Issue we will provide updates on the assessment and management of structural disease in all of these areas. We welcome authors to submit papers on these specific topics.
Dr. David Roberts
Guest Editor
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Keywords
- TAVR
- Mitra-Clip
- Tri-Clip
- Pascal
- TricValve
- PFO closure
- LAAO closure
- cardiac CT
- cardiac MRI
- transoesopha-geal echocardiography
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