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Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 952

Special Issue Editors


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Guest Editor
1. Division of Research and Nephrology Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
2. Instituto de Tecnologías Biomédicas, Universidad de La Laguna, 38200 La Laguna, Spain
3. Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain
Interests: chronic kidney disease; diabetic kidney disease; inflammation; mineral bone metabolism; cardiovascular complications
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Guest Editor
Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
Interests: chronic kidney disease; diabetic kidney disease; inflammation; mineral bone metabolism; cardiovascular complications

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Guest Editor
Research Unit Division, University Hospital Nuestra Señora de la Candelaria, 38010 Santa Cruz de Tenerife, Spain
Interests: chronic kidney disease; diabetes; inflammation; cardiovascular disease; mineral metabolism

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) represents a growing global health challenge, affecting approximately 15% of the population and contributing significantly to morbidity and mortality. Its close association with comorbidities such as diabetes, hypertension, and mineral as well as bone diorders, in addition to its role as a major cardiovascular risk factor from the early stages of the disease, underscore the need for early and effective diagnosis as well as clinical intervention.

The aim of this Special Issue of the Journal of Clinical Medicine is to showcase cutting-edge research and comprehensive reviews focused on the diagnosis and management of CKD without renal replacement therapy across its full clinical aspects. We welcome submissions addressing key areas, including, but not limited to, hypertensive and diabetic kidney disease, cardiorenal syndrome, glomerulonephritis, and genetic renal diseases.

Dr. Juan F. Navarro-González
Dr. Carmen Mora-Fernández
Dr. Javier Donate-Correa
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CKD
  • CKD progression
  • biomarkers
  • disease-modifying treatments
  • diabetic kidney disease
  • cardiorenal disease
  • glomerunephritis
  • genetic kidney diseases

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Published Papers (1 paper)

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Review

14 pages, 370 KB  
Review
The Role of Complement Activation in Diabetic Nephropathy: Current Insights and Future Directions
by Nikolaos Kotsalas, Ariadni Fouza and Maria Daoudaki
J. Clin. Med. 2025, 14(23), 8589; https://doi.org/10.3390/jcm14238589 - 4 Dec 2025
Viewed by 730
Abstract
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD) globally. Beyond metabolic and haemodynamic stress, the complement system has emerged as a contributor to glomerular and tubulointerstitial injury. In type 1 diabetes mellitus (T1DM), complement proteins contribute through autoimmune mechanisms, [...] Read more.
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD) globally. Beyond metabolic and haemodynamic stress, the complement system has emerged as a contributor to glomerular and tubulointerstitial injury. In type 1 diabetes mellitus (T1DM), complement proteins contribute through autoimmune mechanisms, while in type 2 diabetes mellitus (T2DM) they are linked to insulin resistance. In both, complement activation promotes micro- and macrovascular complications through inflammatory pathways that accelerate DN progression. This review summarises the current evidence on the role of complement activation in diabetic nephropathy (DN). First, we outline the mechanisms by which the complement system is activated through the lectin pathway (in which mannoses bind to modified glycosylation structures), the classical pathway (in which C1q recognises immune complexes/damaged self), and the alternative pathway (in which C3 ticks over and amplifies on damaged renal surfaces). Next, we consider the roles of their effector molecules (C3a, C5a, and C5b-9/MAC), and the consequences of regulatory dysfunction (e.g., CD59 dysfunction). When integrated with findings from renal histology, blood and urine biomarkers enable us to evaluate the correlation between prognosis, disease severity, and progression. We will also discuss therapeutic implications, including the rationale behind selective complement inhibition and future intervention strategies. Full article
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