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Clinical Updates in Stem Cell Transplants
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Clinical Updates in Stem Cell Transplants

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1308

Special Issue Editors

Dr. Daniele Avenoso

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Guest Editor
Associate Professor of Hematology, Unit of Blood Disease and Bone Marrow Transplantation, Department of Clinical and Experimental Science, University of Brescia, AST Spedali Civili di Brescia, Brescia, Italy
Interests: AML; CML; lymphoma; allo-HSCT; GVHD
Special Issues, Collections and Topics in MDPI journals
Dr. Michele Malagola

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Guest Editor
Associate Professor of Hematology, Unit of Blood Disease and Bone Marrow Transplantation, Department of Clinical and Experimental Science, University of Brescia, AST Spedali Civili di Brescia, Brescia, Italy
Interests: AML; CML; lymphoma; allo-HSCT; GVHD

Special Issue Information

Dear Colleagues,

We are excited to announce the upcoming Special Issue titled "Clinical Updates in Stem Cell Transplants" in Journal of Clinical Medicine. This Special Issue aims to explore and discuss the latest advancements in the field of allogeneic bone marrow transplants, a rapidly evolving frontier of medicine.

Recent years have seen significant technological and therapeutic progress in allogeneic bone marrow transplantation, greatly improving treatment prospects for patients. New conditioning techniques, enhanced strategies for managing graft-versus-host disease, and advancements in donor selection methods are just a few of the topics that deserve an updated examination. Moreover, the emergence of stem cell-based therapies in various clinical contexts has opened new avenues of research and application that need to be addressed.

We invite researchers and specialists in the field of bone marrow transplants and cellular therapies to contribute original research and reviews that reflect the latest discoveries and innovations. This Special Issue aims to provide a platform to share in-depth scientific knowledge and discuss the current challenges and opportunities in the field of allogeneic bone marrow transplantation.

For more details on how to submit your work, please visit the journal's website. We look forward to your contributions, which will enrich the scientific dialogue and enhance clinical practice in the field of bone marrow transplantation.

Dr. Daniele Avenoso
Dr. Michele Malagola
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • AML
  • CML
  • lymphoma
  • allo-HSCT
  • GVHD
  • MDS
  • AA

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Published Papers (2 papers)

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Research

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14 pages, 1210 KB  
Article
Cholesterol Levels Are Not Associated with Peripheral Blood Stem Cell Mobilization in Healthy Donors
by Sema Seçilmiş, Burcu Aslan Candır, Ersin Bozan, Samet Yaman, Bahar Uncu Ulu, Tuğçe Nur Yiğenoğlu, Dicle İskender, Merih Kızıl Çakar, Mehmet Sinan Dal and Fevzi Altuntaş
J. Clin. Med. 2025, 14(17), 6239; https://doi.org/10.3390/jcm14176239 - 4 Sep 2025
Viewed by 568
Abstract
Background/Objectives: Hematopoietic stem cell (HSCs) mobilization from the bone marrow to the peripheral blood (PB) is a critical step in stem cell transplantation. Although some experimental studies have suggested that cholesterol levels may affect this process, the clinical relevance of lipid profiles in [...] Read more.
Background/Objectives: Hematopoietic stem cell (HSCs) mobilization from the bone marrow to the peripheral blood (PB) is a critical step in stem cell transplantation. Although some experimental studies have suggested that cholesterol levels may affect this process, the clinical relevance of lipid profiles in healthy donors remains unclear. This study aimed to investigate whether serum cholesterol parameters are associated with peripheral blood CD34+ HSC mobilization in healthy stem cell donors. Methods: A total of 251 healthy donors who underwent granulocyte colony-stimulating factor (G-CSF)-based mobilization were retrospectively analyzed. Peripheral blood CD34+ cell counts and yields (×106/kg) were recorded. Laboratory parameters, including total cholesterol, HDL-C, LDL-C, and triglyceride levels were evaluated. Correlations between mobilization outcomes and donor characteristics or laboratory findings were also assessed. Results: No significant association was found between serum lipid parameters (total cholesterol, LDL-C, HDL-C, triglycerides) and CD34+ cell mobilization or yield. However, white blood cell count, hemoglobin level, platelet count, absolute neutrophil count, and lymphocyte count showed significant positive associations with mobilization efficacy. In contrast, body mass index (BMI) was inversely correlated with CD34+ cell yield. Conclusions: Serum cholesterol levels do not appear to influence stem cell mobilization outcomes in healthy donors. Classical hematologic parameters remain reliable predictors of CD34+ cell yield. These findings suggest that cholesterol is not a suitable biomarker for predicting mobilization efficiency in this population group. Full article
(This article belongs to the Special Issue Clinical Updates in Stem Cell Transplants)
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Review

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23 pages, 1892 KB  
Review
Unraveling the Intestinal Microbiota Conundrum in Allogeneic Hematopoietic Stem Cell Transplantation: Fingerprints, Clinical Implications and Future Directions
by Alexandre Soares Ferreira Júnior, Bianca Fernanda Rodrigues da Silva, Jefferson Luiz da Silva, Mariana Trovão da Silva, João Victor Piccolo Feliciano, Iago Colturato, George Maurício Navarro Barros, Phillip Scheinberg, Nelson Jen An Chao and Gislane Lelis Vilela de Oliveira
J. Clin. Med. 2025, 14(19), 6874; https://doi.org/10.3390/jcm14196874 - 28 Sep 2025
Viewed by 463
Abstract
Intestinal dysbiosis represents a critical determinant of clinical outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Distinct microbiota patterns represent potential prognostic biomarkers and therapeutic targets. However, the exponential growth in microbiota research and analytical complexity has created significant interpretive challenges [...] Read more.
Intestinal dysbiosis represents a critical determinant of clinical outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Distinct microbiota patterns represent potential prognostic biomarkers and therapeutic targets. However, the exponential growth in microbiota research and analytical complexity has created significant interpretive challenges for clinicians. This review provides a synthesis of current literature examining microbiota fingerprints and their clinical implications. We analyzed key studies evaluating the clinical implications of intestinal microbiota fingerprints in allo-HSCT. Additionally, we examined current therapeutic strategies for microbiota modulation and approaches for translating research findings into clinical practice. We identified three major microbiota fingerprints: (1) decreased intestinal microbiota diversity, (2) reduced abundance of short-chain fatty acid-producing bacteria, and (3) Enterococcus domination. These fingerprints are associated with critical clinical outcomes including overall survival, Graft-versus-host disease, transplant-related mortality, and infection-related complications. While fecal microbiota transplantation and dietary interventions appear promising, current studies suffer from limited sample sizes and lack standardized protocols. Despite significant advances in microbiota research, biological, methodological, and logistical challenges continue to hinder its clinical translation. Understanding microbiota fingerprints represents a promising avenue for improving allo-HSCT outcomes. However, successful clinical implementation requires standardized methodologies, mechanistic studies, and multi-center collaborations to translate research into actionable clinical tools. Full article
(This article belongs to the Special Issue Clinical Updates in Stem Cell Transplants)
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