Gastrointestinal Cancer: Outcomes and Therapeutic Management—2nd Edition
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 222
Special Issue Editor
Interests: surgical oncology; clinical trials; meta-analysis; systematic review; surgical research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal cancers represent a highly heterogeneous group of malignancies arising from the esophagus, stomach, small bowel, colon, rectum, pancreas, liver, and biliary tract, as well as a spectrum of neuroendocrine tumors located throughout the digestive system. Their therapeutic management and clinical outcomes have evolved rapidly over the past decade, driven by innovations in diagnostics, minimally invasive interventions, systemic therapies, and multidisciplinary care pathways.
This second edition will build upon the success of the previous Special Issue, which featured 11 published articles, and will broaden the scientific scope to reflect the full range of current and emerging treatment modalities, both surgical and non-surgical.
Advances in endoscopic therapy have transformed the management of early-stage gastrointestinal neoplasia, enabling curative-intent treatment for selected cases of early gastric cancer, early esophageal squamous cell carcinoma and adenocarcinoma, rectal lesions, and duodenal or rectal neuroendocrine tumors through techniques such as EMR, ESD, EFTR, and hybrid procedures.
At the same time, systemic and medical oncology treatments—including chemotherapy, targeted therapies, and rapidly expanding immunotherapy options—have redefined outcomes for patients with advanced or non-surgical GI cancers. Precision oncology, molecular profiling, and biomarker-driven treatment selection are now playing an increasingly central role in therapeutic decision-making, helping clinicians tailor interventions to individual tumor biology.
Surgical management has also progressed significantly, with open, laparoscopic, and robotic platforms delivering improved perioperative and functional outcomes. Enhanced preoperative staging, multimodal treatment planning, and advanced imaging support optimized decision-making across the entire disease spectrum.
For this Special Issue, we will prioritize research on clinical outcomes with clear, quantifiable endpoints such as overall survival, disease-free survival, cancer-specific survival, progression-free survival, treatment-related morbidity, quality of life, and functional outcomes.
This Special Issue will showcase high-quality research and state-of-the-art reviews covering the full continuum of care for gastrointestinal malignancies, including the following topics:
- Surgical, endoscopic, and interventional techniques;
- Systemic therapy, immunotherapy, and targeted molecular treatments;
- Multidisciplinary clinical pathways and treatment sequencing;
- Precision diagnostics, biomarkers, and individualized treatment strategies;
- Short- and long-term oncological, functional, and quality-of-life outcomes;
- Emerging technologies and future directions in GI cancer management.
We welcome original research articles, clinical studies, systematic reviews, meta-analyses, and translational insights that contribute to improved therapeutic decision-making and patient-centered outcomes in gastrointestinal oncology.
Dr. Maximos Frountzas
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- surgical oncology
- gastrointestinal cancer
- esophageal
- gastric
- hepatic
- biliary
- pancreatic
- colon
- rectal
- neoplasm
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