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JCM
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Clinical Therapeutic Advances of Mitral Regurgitation
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Clinical Therapeutic Advances of Mitral Regurgitation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 443

Special Issue Editor

Dr. Angelo Squeri

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Guest Editor
Integrated Cardiovascular Imaging Department, GVM Care & Research, Maria Cecilia Hospital, Cotignola, Italy
Interests: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography

Special Issue Information

Dear Colleagues,

Mitral regurgitation (MR) remains one of the most prevalent valvular heart diseases worldwide, with a substantial clinical impact. In recent years, the field has witnessed major advances in the understanding, diagnosis, and treatment of MR. Novel imaging techniques; refined classification systems, including atrial functional MR; the development of transcatheter mitral valve repair and replacement options; and the extensive use of surgical mitral valve repair techniques have reshaped clinical practice. These innovations have expanded therapeutic possibilities, particularly for high-risk or inoperable patients. Despite this progress, important questions remain regarding optimal patient selection, timing of intervention, and long-term outcomes following novel therapies.

This Special Issue aims to present the latest developments in clinical management, interventional strategies, and medical therapies for MR.

We encourage authors to submit original research articles or comprehensive review papers that explore any aspect of MR; we are particularly interested in translational findings and clinical applications.

Dr. Angelo Squeri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mitral regurgitation
  • mitral valve prolapse
  • cardiovascular interventions
  • heart surgery
  • echocardiography
  • mag-netic resonance imaging
  • computed tomography

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Published Papers (1 paper)

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Research

12 pages, 849 KB  
Article
Gender-Based Analysis of Patients Undergoing Mitral Valve Surgery
by Shekhar Saha, Sophie Meerfeld, Konstanze Maria Horke, Martina Steinmauer, Ahmad Ali, Gerd Juchem, Sven Peterss, Christian Hagl and Dominik Joskowiak
J. Clin. Med. 2025, 14(19), 7072; https://doi.org/10.3390/jcm14197072 - 7 Oct 2025
Viewed by 325
Abstract
Objectives: To optimise surgical treatment of mitral valve disease (MVD), a better understanding of gender-based differences is required. In this study, we analyse the gender-based differences among patients undergoing mitral valve surgery. Methods: Between January 2019 and December 2024, 809 consecutive [...] Read more.
Objectives: To optimise surgical treatment of mitral valve disease (MVD), a better understanding of gender-based differences is required. In this study, we analyse the gender-based differences among patients undergoing mitral valve surgery. Methods: Between January 2019 and December 2024, 809 consecutive patients were admitted to our centre for surgery for MVD. We analysed the patient characteristics, surgical details, postoperative and short-term outcomes of these patients. Results: Females (31.8%) undergoing mitral valve (MV) surgery were older (p < 0.001). Females had a higher rate of atrial fibrillation (p < 0.001), Rheumatoid arthritis (RA) (p = 0.002) and malignancy (p = 0.030). Furthermore, females were more often admitted to the intensive care unit (ICU) preoperatively (p = 0.037). Among these patients, 419 patients underwent isolated MV surgery. Furthermore, males underwent minimally invasive MV surgery more often (p = 0.004). Females had higher rates of combined MVD (p < 0.001) and combined MS (p < 0.001). Males had higher rates of severe mitral regurgitation (MR) (p = 0.041) and Left Atrium (LA) dilation (p = 0.004). Females exhibited higher rates of severe Tricuspid Regurgitation (TR) (p = 0.032) and pulmonary hypertension (p < 0.001). males had higher rates of posterior mitral leaflet (PML) prolapse (p < 0.001) and Flail leaflets (p < 0.001). Males underwent mitral valve repair (MVr) more often (p = 0.002). Early MACCE were reported in 5.1% of the patients. Freedom from major adverse cardiac and cerebrovascular events (MACCE) was comparable at 1 year and three years (p = 0.548). Prognosis and freedom from events were comparable between genders. Conclusions: Mitral valve disease presents differently across genders. There exist fundamental differences in the pathophysiological processes and presentation of mitral valve disease. Mitral valve surgery can be carried out with low mortality and morbidity rates irrespective of gender. Full article
(This article belongs to the Special Issue Clinical Therapeutic Advances of Mitral Regurgitation)
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