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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Patient-Oriented Treatments for Heart Failure
edited by Elisa Fabbri
submission deadline 20 Oct 2025 | 2 articles | Viewed by 670 | Submission Open
Keywords: heart failure; personalized care; patient-centered treatment; aging; comorbidity; multimorbidity; frailty
(This special issue belongs to the Section Cardiology)
Current State of the Art in Breast Reconstruction
edited by Ara A. Salibian and David Daar
submission deadline 20 Oct 2025 | 1 articles | Viewed by 668 | Submission Open
Keywords: breast reconstruction; microsurgery; breast cancer; breast implant; DIEP Flap
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Current Status of Endovascular Therapy for Acute Ischemic Stroke—2nd Edition submission deadline 20 Oct 2025 | Viewed by 320 | Submission Open
Keywords: endovascular therapy (EVT); cerebrovascular disease; thrombectomy; thrombolysis; ischemic stroke; interventional stroke therapy
(This special issue belongs to the Section Clinical Neurology)
Current Clinical Treatments and Challenges for Heart Failure and Cardiogenic Shock submission deadline 20 Oct 2025 | Viewed by 302 | Submission Open
Keywords: cardiogenic shock; heart failure; mechanical circulatory support; Impella; veno-arterial ECMO; unloading; heart failure; heart transplant; artificial heart; left ventricular assist devices
(This special issue belongs to the Section Cardiology)
Innovative Approaches to the Epidemiology, Diagnosis, and Treatment of Systemic Sclerosis: Bridging Gaps in Early Detection and Personalized Therapy submission deadline 20 Oct 2025 | Viewed by 260 | Submission Open
Keywords: systemic sclerosis; scleroderma; epidemiology; biomarkers; personalized therapy; therapeutic strategies
(This special issue belongs to the Section Clinical Neurology)
Advances in the Management of Oral Lichen Planus: A Comprehensive Clinical Perspective
edited by Zuzanna Ślebioda and
submission deadline 20 Oct 2025 | Viewed by 184 | Submission Open
Keywords: oral lichen planus; treatment; topical treatment; systemic treatment; oral mucosa; oral pathology; immunosuppressive therapy
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Minimally Invasive Heart Surgery: 2nd Edition
edited by
submission deadline 20 Oct 2025 | Viewed by 134 | Submission Open
Keywords: minimally invasive; aortic valve; mitral valve; hybrid approaches; techniques; strategies
(This special issue belongs to the Section Cardiology)
Clinical Prevention and Treatment of Graft-Versus-Host Disease (GVHD)
edited by
submission deadline 20 Oct 2025 | Viewed by 98 | Submission Open
Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; immunosuppressive therapy; JAK inhibitors; GVHD biomarkers; transplantation complications
(This special issue belongs to the Section Hematology)
Implant Dentistry: New Challenges and Complication Management
edited by Jordi Gargallo
submission deadline 20 Oct 2025 | Viewed by 97 | Submission Open
Keywords: navigation surgery; accuracy; computer-aided surgery; computer-assisted; three-dimensional imaging; fixed implant prostheses; zirconia; CAD/CAM; patient satisfaction; peri-implantitis; quality of life; retreatment; tooth loss; connective tissue; keratinized tissue; soft tissue management; bone regeneration; bone grafting; immediate implant placement; immediate implant loading
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Updates and Perspectives on Corneal Surgery
edited by Nicola Cardascia, Maria Gabriella la Tegola, , Giovanni Alessio and Giacomo Boscia
submission deadline 23 Oct 2025 | Viewed by 125 | Submission Open
Keywords: cornea; corneal surgey; keratoplasty; amniotic membrane; rejection; failure
(This special issue belongs to the Section Ophthalmology)
Clinical Updates and Perspectives on Transcranial Magnetic Stimulation (TMS)—2nd Edition submission deadline 23 Oct 2025 | Viewed by 94 | Submission Open
Keywords: non-invasive brain stimulation; transcranial magnetic stimulation; motor cortex; neuroplasticity; motor learning; dementia; stroke; movement disorders; depression; spinal cord; neuropsychiatric disorders
(This special issue belongs to the Section Clinical Neurology)
News in the Pathogenesis, Diagnosis and Treatment of Systemic Sclerosis
edited by Mayka Freire and Bernardo Sopeña
submission deadline 24 Oct 2025 | 2 articles | Viewed by 1924 | Submission Open
Keywords: systemic sclerosis; scleroderma; capillaroscopy; autoantibodies; pathogenesis
(This special issue belongs to the Section Immunology)
Challenges and Advances in Geriatrics and Gerontology
edited by Elisa Fabbri
submission deadline 24 Oct 2025 | 1 articles | Viewed by 524 | Submission Open
Keywords: aging; geriatric medicine; frailty; multimorbidity; sarcopenia; cognition; personalized-care; healthy longevity; decision making-management; prevention; artificial intelligence
(This special issue belongs to the Section Geriatric Medicine)
Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types
edited by Andrea Paradisi
submission deadline 24 Oct 2025 | Viewed by 114 | Submission Open
Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)
(This special issue belongs to the Section Dermatology)
Ischemic and Hemorrhagic Complications of Uncommon Cerebrovascular Diseases: Cutting-Edge Clinical Research, Reviews, and Expert Opinions
edited by Mariel G. Kozberg and Alexis T. Roy
submission deadline 24 Oct 2025 | Viewed by 101 | Submission Open
Keywords: cerebrovascular disease; ischemic stroke; hemorrhagic stroke; genetics; vasculopathy; headache; superficial siderosis; vascular malformations
(This special issue belongs to the Section Clinical Neurology)
Hypertension and Cardiovascular Disease: Clinical Updates and Perspectives submission deadline 25 Oct 2025 | 9 articles | Viewed by 9192 | Submission Open
Keywords: hypertension management; cardiovascular risk assessment; novel antihypertensive therapies; hypertension in pregnancy; hypertensive emergencies; cardiovascular disease prevention; pharmacological interventions for cardiovascular disease
(This special issue belongs to the Section Cardiovascular Medicine)
Hereditary Hemorrhagic Telangiectasia: Recent Advances and Future Challenges—2nd Edition submission deadline 25 Oct 2025 | 7 articles | Viewed by 7405 | Submission Open
Keywords: hereditary hemorrhagic telangiectasia (HHT); ALK1; ACVRL1; endoglin (ENG); arteriovenous malformations; embolization; VEGF
(This special issue belongs to the Section Vascular Medicine)
Colon and Rectal Surgery: Current Clinical Practice and Future Trends
edited by Konstantinos Romanidis
submission deadline 25 Oct 2025 | 6 articles | Viewed by 6854 | Submission Open
Keywords: colorectal surgery; colorectal cancer; complications; metastasis; artificial intelligence; cancer metabolism
(This special issue belongs to the Section General Surgery)
Digital Health Technologies in Parkinson’s Disease and Related Disorders
edited by Ruth B. Schneider and Christine Doss Esper
submission deadline 25 Oct 2025 | 6 articles | Viewed by 5778 | Submission Open
Keywords: digital health technologies; telehealth; wearables; smartphones; Parkinson’ s disease; atypical parkinsonism
(This special issue belongs to the Section Clinical Neurology)
Clinical Perspectives on Surgical Management of Knee Injuries
edited by Min Jung
submission deadline 25 Oct 2025 | 4 articles | Viewed by 4565 | Submission Open
Keywords: osteoarthritis; meniscal repair; ligament reconstruction; cartilage restoration; knee surgery
(This special issue belongs to the Section Orthopedics)
Current Status, Challenges and Future Directions in Aortic Valve Replacement
edited by Guglielmo Saitto and Giovanni Alfonso Chiariello
submission deadline 25 Oct 2025 | 4 articles | Viewed by 3668 | Submission Open
Keywords: aortic valve; aortic valve replacement; minimally invasive surgery; robotic surgery; TAVI; ross operation; root enlargement techniques; heart team; lifetime management
(This special issue belongs to the Section Cardiology)
Assessment and Treatment of Trauma Patients
edited by
submission deadline 25 Oct 2025 | 2 articles | Viewed by 2735 | Submission Open
Keywords: trauma surgery; prehospital detection of trauma; assessment of trauma; trauma scale; trauma evaluation; trauma surgery
(This special issue belongs to the Section Emergency Medicine)
Paediatric Anaesthesia: Clinical Updates and Perspectives
edited by Peter Marhofer, Philipp Opfermann and Markus Zadrazil
submission deadline 25 Oct 2025 | 4 articles | Viewed by 2601 | Submission Open
Keywords: pediatric anesthesia; anesthesia; conduction; ultrasonography; conscious sedation; deep sedation; drug-related side effects and adverse reactions; neurotoxicity syndromes
(This special issue belongs to the Section Anesthesiology)
Current Treatment and Future Options of Ischemic Stroke
edited by Raluca Elena Sandu and Carmen Valeria Albu
submission deadline 25 Oct 2025 | 1 articles | Viewed by 2310 | Submission Open
Keywords: ischemic stroke; stroke; neuroinflammation; cerebral ischemia; thrombolysis; neuroprotection; rehabilitation strate-gies; stroke biomarkers; extracellular vesicles; stem cell therapy; post-stroke recovery; cerebral ischemia; advanced imaging in stroke; personalized stroke treatment
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Temporomandibular Joint Diseases submission deadline 25 Oct 2025 | 3 articles | Viewed by 2087 | Submission Open
Keywords: temporomandibular joint disorders; dental occlusion; chronic pain; occlusal splints; risk factors
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Migraine Headache: Symptoms, Diagnosis, and Current Treatment
edited by Ināra Logina
submission deadline 25 Oct 2025 | 2 articles | Viewed by 1887 | Submission Open
Keywords: migraine; headache disorders; burden of headache disorders; acute and preventive treatment of migraine; neuropathic pain
(This special issue belongs to the Section Clinical Neurology)
Optimizing Outcomes in Scoliosis and Complex Spinal Surgery
edited by Francis C. Lovecchio
submission deadline 25 Oct 2025 | 2 articles | Viewed by 1752 | Submission Open
Keywords: outcomes; complications; scoliosis; adult spinal deformity; proximal junctional kyphosis; complex spine; pseudarthrosis
(This special issue belongs to the Section Orthopedics)
Management in Autism Spectrum Disorder: From Biomarkers to Precision Medicine submission deadline 25 Oct 2025 | 2 articles | Viewed by 1731 | Submission Open
Keywords: autism; autism spectrum disorder; neurodevelopmental disorders; epigenetics of autism; genetic inheritance; immunogenetics
(This special issue belongs to the Section Mental Health)
Targeted Medicine in Postoperative Pain Management
edited by and Eleni Moka
submission deadline 25 Oct 2025 | 2 articles | Viewed by 1419 | Submission Open
Keywords: precision medicine; postoperative analgesia; pain control; drug delivery systems; surgical pain management; personalized interventions
(This special issue belongs to the Section Anesthesiology)
Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities
edited by Shany Sherman
submission deadline 25 Oct 2025 | 2 articles | Viewed by 1360 | Submission Open
Keywords: healthcare utilization; inflammatory skin diseases; photodermatoses; collagen vascular disease; immunobullous disorders; graft-versus-host disease
(This special issue belongs to the Section Dermatology)
Advancements in Diagnostic Innovations in Sports Cardiology
edited by Giuseppe Di Gioia, Maria Rosaria Squeo and
submission deadline 25 Oct 2025 | 1 articles | Viewed by 1035 | Submission Open
Keywords: athletes; cardiovascular prevention; risk factors; sport cardiology; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort
edited by Cesare Gregoretti and Giuliano Lo Bianco
submission deadline 25 Oct 2025 | 2 articles | Viewed by 998 | Submission Open
Keywords: pain management; pain medicine; anesthesia; analgesia; anesthesiology
(This special issue belongs to the Section Anesthesiology)
Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases
edited by and
submission deadline 25 Oct 2025 | 1 articles | Viewed by 788 | Submission Open
Keywords: echocardiography; cardiac diseases; 3D echo; stress; myocardial strain; intracardiac; subclinical cardiac disease
(This special issue belongs to the Section Cardiology)
Cardiac Magnetic Resonance Imaging: Current Techniques and Future Directions
edited by Ioannis Botis and
submission deadline 25 Oct 2025 | 1 articles | Viewed by 741 | Submission Open
Keywords: cardiac magnetic resonance imaging; cardiovascular magnetic resonance; cardiac imaging; multimodality imaging; parametric mapping; late gadolinium enhancement; myocardial perfusion; myocardial viability; cardiomyopathies; heart failure
(This special issue belongs to the Section Cardiology)
Clinical Trends and Prospects in Laboratory Hematology
edited by
submission deadline 25 Oct 2025 | 1 articles | Viewed by 694 | Submission Open
Keywords: laboratory hematology; hemostasis; flow cytometry; molecular diagnostics; blood cells; complete blood count
(This special issue belongs to the Section Clinical Laboratory Medicine)
Endoscopic Diagnosis and Treatments of Gastrointestinal Diseases
edited by Madalina Ilie and Mihai Ciocîrlan
submission deadline 25 Oct 2025 | 1 articles | Viewed by 532 | Submission Open
Keywords: esogastric lesions; pancreatic diseases; colorectal lesions; hepatobiliary diseases; optical endoscopy; endoscopic ultrasound; upper and lower endoscopy; endoscopic retrograde cholangiopancreatography
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Hand Surgery: Latest Advances and Prospects
edited by and Lorenzo Rocchi
submission deadline 25 Oct 2025 | 1 articles | Viewed by 420 | Submission Open
Keywords: hand surgery; musculoskeletal and nerve disorders; innovative surgical procedures; minimally invasive techniques; rehabilitation strategies; robotic surgery
(This special issue belongs to the Section Orthopedics)
Robot-Assisted Surgery: Current Trends and Future Directions
edited by , Claudio Bisegna and Michele Morelli
submission deadline 25 Oct 2025 | Viewed by 276 | Submission Open
Keywords: robotic surgery; minimally invasive surgery; urology; artificial intelligence; augmented reality; public health; innovation; laparoscopic surgery; surgical platforms; surgical outcomes
(This special issue belongs to the Section General Surgery)
Interventional Cardiology: Recent Advances and Future Perspectives
edited by Cristina Aurigemma and Luigi Cappannoli
submission deadline 25 Oct 2025 | Viewed by 190 | Submission Open
Keywords: interventional cardiology; percutaneous coronary intervention (PCI); transcatheter aortic valve implantation (TAVI); structural heart disease; coronary artery disease; imaging and artificial intelligence; antithrombotic therapy; future technologies in cardiology; personalized cardiovascular care; minimally invasive interventions
(This special issue belongs to the Section Cardiology)
Testicular Cancer: Clinical Advances in Diagnosis and Treatment
edited by , Andreas Maxeiner and
submission deadline 25 Oct 2025 | Viewed by 169 | Submission Open
Keywords: testicular cancer; ultrasound imaging; computed tomography; new imaging modalities; personalized medicine; oncology; surgical treatment
(This special issue belongs to the Section Oncology)
Oral and Maxillofacial Surgery: Current Advances and Future Directions
edited by Niedzielska Iwona
submission deadline 25 Oct 2025 | Viewed by 142 | Submission Open
Keywords: oral and maxillofacial surgery; reconstructive surgery; periodontitis; dental implants; maxillofacial deformities
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management of Frailty
edited by , Walter Sepulveda-Loyola and
submission deadline 25 Oct 2025 | Viewed by 139 | Submission Open
Keywords: frailty; comprehensive geriatric assessment; assessment; monitoring; functional decline; physical performance; ex-ercise interventions; nutritional strategies; interventions; adverse outcomes
(This special issue belongs to the Section Geriatric Medicine)
New Clinical Insights into Cardiac Pacing and Cardiac Resynchronization Therapy
edited by Massimo Zecchin
submission deadline 25 Oct 2025 | Viewed by 131 | Submission Open
Keywords: cardiac pacing; cardiac resynchronization therapy (CRT); cardiac conduction system pacing; left bundle branch area pacing; leadless pacing; short- and long-term outcomes; implantation technique
(This special issue belongs to the Section Cardiology)
Respiratory Medicine in the Oldest-Old
edited by
submission deadline 25 Oct 2025 | Viewed by 120 | Submission Open
Keywords: oldest-old; respiratory system with aging; pneumonia; epidemiology; COPD; interstitial lung disease; bronchial asthma; lung cancer; mycobacterial or fungal infections; peri-/post-operative status; respiratory frailty; social problems and end of life
(This special issue belongs to the Section Respiratory Medicine)
Oral Cancer: Clinical Updates and Perspectives submission deadline 25 Oct 2025 | Viewed by 119 | Submission Open
Keywords: oral cancer; oral surgery; dental implant; tooth extraction; oral health; early detection; biomarkers; targeted therapy; immunotherapy
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances and Clinical Outcomes of Endocrinology
edited by Stefana Catalina Bilha and
submission deadline 25 Oct 2025 | Viewed by 115 | Submission Open
Keywords: endocrinology; obesity; metabolic and bone disease; chronic conditions
(This special issue belongs to the Section Endocrinology & Metabolism)
Management and Prognosis of Spinal Surgery
edited by Francesco Costa
submission deadline 25 Oct 2025 | Viewed by 114 | Submission Open
Keywords: spine; spinal surgery; spinal biomechanics; microneurosurgery; vertebral oncology
(This special issue belongs to the Section Clinical Neurology)
Advances in Primary Sclerosing Cholangitis: Pathogenesis, Diagnosis and Emerging Therapies
edited by Konstantinos H. Katsanos and Fotios S. Fousekis
submission deadline 25 Oct 2025 | Viewed by 113 | Submission Open
Keywords: cholangiocarcinoma; primary sclerosing cholangitis; cholestatic; inflammatory bowel disease; liver
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition submission deadline 25 Oct 2025 | Viewed by 111 | Submission Open
Keywords: aortic valve pathologies; minimally invasive approach; aortic valve repair; aortic valve replacement; imaging techniques
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances in Imaging and Interventional Techniques for Renal and Adrenal Diseases
edited by Francesco Ziglioli and Umberto Vittorio Maestroni
submission deadline 25 Oct 2025 | Viewed by 107 | Submission Open
Keywords: renal cancer; adrenal mass; robotic surgery; minimally invasive techniques; radiomics; tailored treatment
(This special issue belongs to the Section Nephrology & Urology)
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