Contemporary Insights in Pulmonary Hypertension: Moving from Algorithms to Phenotypes

Dear Colleagues,

Pulmonary hypertension (PH) comprises a heterogeneous group of disorders with diverse pathobiology, clinical trajectories, and therapeutic responses. Although guideline-based algorithms and risk scores have improved standardization of care—particularly in pulmonary arterial hypertension—many aspects of real-world PH management remain poorly addressed by rigid frameworks alone.

This Special Issue aims to present contemporary, state-of-the-art review articles that move beyond algorithmic approaches toward phenotype-informed, pragmatic clinical decision-making across the spectrum of pulmonary hypertension.

Priority topics include, but are not limited to:

• Risk stratification and prognostication in pulmonary arterial hypertension (WHO Group I).
• Phenotype-driven treatment strategies for PH due to left heart disease, lung disease or hypoxia, chronic thromboembolic disease, and complex or systemic conditions (WHO Groups II–V).
• Integration of comorbidities, symptom burden, and disease trajectory into therapeutic decision-making.
• Real-world challenges in applying guidelines to heterogeneous patient populations.
• Patient-centered care, quality of life, and integration of palliative care across PH phenotypes.

This Special Issue will focus on invited narrative and clinical review articles that emphasize conceptual clarity, clinical relevance, and forward-looking perspectives. Contributions should critically appraise existing evidence, identify unresolved challenges, and propose practical approaches to improve care in routine clinical settings.

Dr. Rahul Gupta Argula
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.