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The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)
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The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1277

Editors

Dr. Salvatore Giordano

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Guest Editor
Division of Cardiology, Department of Medical and Surgical Sciences, “Magna Graecia” University, 88100 Catanzaro, Italy
Interests: cardiovascular medicine; heart failure; myocardial infarction; atherosclerosis; acute myocardial infarction; interventional cardiology; coronary angiography; PCI; cardiac catheterization; cardiovascular pharmacology
Dr. Arturo Giordano

E-Mail Website
Guest Editor
Interventional Cardiology Unit, Pineta Grande Hospital, 81030 Castel Volturno, CE, Italy
Interests: stents; arteries; vascular diseases; angioplasty; atherosclerosis; carotid arteries; angiography; aortic diseases; mitral valve; transcatheter aortic valve implantation
Dr. Nicola Corcione

E-Mail Website
Guest Editor
Interventional Cardiology Unit, Pineta Grande Hospital, 81030 Castel Volturno, CE, Italy
Interests: arteries; angioplasty; interventional cardiology

Special Issue Information

Dear Colleagues,

Transcatheter aortic valve implantation (TAVI) has rapidly evolved from an alternative treatment for high-risk surgical candidates to a mainstream therapy across the surgical-risk spectrum. Understanding the latest innovations, challenges, and evidence is essential for cardiologists, cardiac surgeons, imaging specialists, and researchers. This Special Issue presents state-of-the-art developments in the dynamic transformation of TAVI in contemporary cardiovascular medicine.

We explore emerging perspectives reshaping TAVI practice, including advances in valve technology, optimization of patient selection, contemporary imaging strategies, procedural refinements, and long-term management considerations. Persistent challenges include durability, conduction disturbances, vascular complications, antithrombotic therapy, and TAVI in complex anatomies—including bicuspid valves and younger patient populations.

Our aim is to illuminate the latest evidence and conceptual advancements for more precise and patient-centered use of TAVI. This issue stimulates informed debate, encourages innovation, and supports improved clinical decision-making.

The articles provide a comprehensive and forward-looking view of TAVI practice. Updated perspectives cover device iterations, cutting-edge imaging modalities for procedural planning, predictors of clinical outcomes, and strategies for reducing complications. Additionally, analyses cover TAVI durability, insights into expanding indications, and discussions on future directions such as fully personalized valve therapy and the role of artificial intelligence in pre-procedural assessment.

We invite clinicians, researchers, and industry partners to engage and continue advancing the field through collaborative inquiry and innovation. As TAVI continues to transform the management of aortic stenosis worldwide, diverse perspectives and rigorous research are essential to address remaining knowledge gaps.

This Special Issue underscores continued exploration and refinement in TAVI. We hope to support ongoing improvements in patient outcomes and inspire future advancements.

Dr. Salvatore Giordano
Dr. Arturo Giordano
Dr. Nicola Corcione
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcatheter aortic valve implantation (TAVI)
  • structural heart intervention
  • aortic stenosis
  • valve technology and durability
  • imaging and procedural optimization

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Published Papers (2 papers)

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Research

12 pages, 430 KB  
Article
Impact of Aortic Valve Calcium Burden on Paravalvular Leak Across Balloon-Expandable and Self-Expanding Valves: Insights from a Large TAVR Cohort
by Ziad Arow, Laurent Lepage, Juri Iwata, Akiko Masumoto, Abid Assali, Mustafa Gabarin, Rawia Hussein-Aro, Chiara De Biase, Nicolas Dumonteil, Didier Tchetche and Laurent Bonfils
J. Clin. Med. 2026, 15(9), 3239; https://doi.org/10.3390/jcm15093239 - 24 Apr 2026
Viewed by 441
Abstract
Background: Aortic valve calcium score (AVCS) is associated with an increased risk of paravalvular leak (PVL) after Transcatheter aortic valve replacement (TAVR). We aimed to evaluate the association between AVCS burden and procedural outcomes, particularly PVL, and to determine whether valve platform performance [...] Read more.
Background: Aortic valve calcium score (AVCS) is associated with an increased risk of paravalvular leak (PVL) after Transcatheter aortic valve replacement (TAVR). We aimed to evaluate the association between AVCS burden and procedural outcomes, particularly PVL, and to determine whether valve platform performance differs according to calcium burden. Methods: This study included patients with severe aortic stenosis undergoing TAVR with balloon-expandable (Sapien platform) or self-expanding (Evolut and Navitor platforms) valves. The primary endpoint was the rate of any and moderate or greater PVLs according to AVCS burden (<3000 vs. ≥3000 AU). Valve platform comparisons were performed within each calcium stratum, and additional analyses evaluated PVLs in contemporary-generation valves. Results: A total of 4483 patients were included, of whom 1134 had an AVCS ≥ 3000 AU, and 3349 had an AVCS < 3000 AU. Any type of PVL occurred more frequently in the AVCS ≥ 3000 group (59% vs. 54%; p = 0.010), as did moderate or greater PVLs (5% vs. 3%; p = 0.011). In multivariable analysis, both SEV implantation and AVCS ≥ 3000 AU were independent predictors of moderate or greater PVL, while the interaction between AVCS burden and valve platform was not significant. When restricted to contemporary-generation valves, PVL rates were lower overall but remained higher in patients with an AVCS ≥ 3000 AU (4.4% vs. 2.4%; p = 0.001), with smaller differences between valve platforms. Conclusions: A higher AVCS is associated with increased PVLs after TAVR. BEVs showed lower rates of moderate or greater PVLs than SEVs, although no statistically significant interaction between AVCS burden and valve platform was observed. With contemporary-generation valves, overall PVL rates were reduced, and platform differences were attenuated. Full article
(This article belongs to the Special Issue The New Perspective in Transcatheter Aortic Valve Implantation (TAVI))
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12 pages, 1117 KB  
Article
Myocardial Work Indices Predict Survival Post TAVI in Aortic Stenosis Patients
by Michał Jakub Błaszkiewicz, Tomasz Grzegorz Witkowski, Wojciech Bombała, Michał Kosowski, Piotr Kübler, Krzysztof Aleksandrowicz, Ewa Anita Jankowska and Marcin Protasiewicz
J. Clin. Med. 2026, 15(4), 1645; https://doi.org/10.3390/jcm15041645 - 22 Feb 2026
Viewed by 525
Abstract
Background: Left Ventricle Myocardial Work (LVMW) has shown utility in assessing patients with aortic stenosis (AS) in recent studies. In the present study, we evaluated the predictive value and optimal cut-off values of LVMW parameters measured prior to TAVI that may be [...] Read more.
Background: Left Ventricle Myocardial Work (LVMW) has shown utility in assessing patients with aortic stenosis (AS) in recent studies. In the present study, we evaluated the predictive value and optimal cut-off values of LVMW parameters measured prior to TAVI that may be associated with increased mortality in AS patients. Methods: A total of 116 consecutive patients who were qualified for TAVI between March 2021 and November 2022 were evaluated. Pre-procedural LVMW indices (GWI, GCW, GWW, and GWE) were assessed and long-term survival was analysed. Survival and influencing factors were evaluated using univariate and multivariate Cox proportional hazard models, with significant factors subsequently included in cut-off analysis. Results: The median survival time following the TAVI procedure was 1404 (1143–1549) days, with a maximum observation period of 1721 days. All-cause mortality during the follow-up period reached 29%. Multivariate analysis revealed that EF, GLS, GWI, GWE and GCW before TAVI were independent predictors of all-cause mortality. We identified 1975 mmHg, 1497 mmHg and 85% as optimal cut-off values for GCW, GWI and GWE, which allow for significant stratification of patients according to risk. Conclusions: In this analysis, baseline-assessed parameters such as GLS, GWI, GWE, and GCW emerged as independent predictors of all-cause mortality. The proposed cut-off values clearly separated patient groups with different survival outcomes. Full article
(This article belongs to the Special Issue The New Perspective in Transcatheter Aortic Valve Implantation (TAVI))
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