Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 17
Special Issue Editor
Special Issue Information
Dear Colleagues,
The surgical management of early-stage non-small cell lung cancer (NSCLC) has long regarded lobectomy as the standard of care. However, segmentectomy—an anatomical sublobar resection that preserves more pulmonary parenchyma—has gained increasing attention as an oncologically acceptable alternative for select patients. Recent randomized trials have supported this shift in practice: the JCOG0802/WJOG4607L trial demonstrated the statistical superiority of segmentectomy over lobectomy in terms of overall survival, while the CALGB 140503 trial confirmed the non-inferiority of segmentectomy for disease-free survival in patients with peripheral stage IA tumors.
Segmentectomy offers the advantage of better postoperative pulmonary function while maintaining adequate oncologic control, particularly in small, peripherally located tumors. Conversely, lobectomy provides wider resection margins and facilitates more comprehensive lymph node dissection, reducing the risk of locoregional recurrence.
This Special Issue aims to explore contemporary evidence and evolving perspectives on segmentectomy and lobectomy for early-stage NSCLC. We welcome submissions that provide novel insights, refine patient selection strategies, evaluate perioperative and long-term outcomes, or challenge existing paradigms in thoracic oncology.
Scope of the Special Issue
Submissions may include but are not limited to
- Comparative studies of lobectomy vs. segmentectomy (oncologic and functional outcomes);
- Surgical techniques and innovations in anatomical segmentectomy;
- Imaging, AI, and preoperative planning for sublobar resection;
- Lymph node dissection strategies in limited resections;
- Risk stratification tools for surgical decision-making;
- Real-world data and guideline implementation.
Dr. Yujin Kudo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lung cancer
- segmentectomy
- lobectomy
- thoracic surgery
- early-stage NSCLC
- oncologic outcomes
- pulmonary function
- surgical planning
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