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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiopulmonary Resuscitation in Emergency Care Units submission deadline 20 Feb 2026 | 4 articles | Viewed by 5910 | Submission Open
Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes
(This special issue belongs to the Section Emergency Medicine)
Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management submission deadline 20 Feb 2026 | 4 articles | Viewed by 5844 | Submission Open
Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Updates on Lumbar Spine Surgery for Degenerative Diseases
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5597 | Submission Open
Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Gastrointestinal Inflammation
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5171 | Submission Open
Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interstitial Lung Disease: From Diagnosis to Treatment
edited by and Tomohisa Baba
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4865 | Submission Open
Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds
(This special issue belongs to the Section Respiratory Medicine)
Intraocular Lenses for Cataract Surgery: Clinical Advances and Perspectives
edited by Choul Yong Park
submission deadline 20 Feb 2026 | 5 articles | Viewed by 4692 | Submission Open
Keywords: cataract surgery; intraocular lens; IOL formula; optic; complication; presbyopia; refractive
(This special issue belongs to the Section Ophthalmology)
Clinical Trends in Cardiomyopathy
edited by Giulia Iannaccone
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4586 | Submission Open
Keywords: cardiomyopathy; genetics; treatment; targeted therapy; prognosis; long-term follow up
(This special issue belongs to the Section Cardiology)
Neurosurgery: Recent Advances and New Perspectives in Skull Base Approaches
edited by Sèbastien Froelich and Matteo De Simone
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4545 | Submission Open
Keywords: skull base; neuroanatomy; tumors; augmented reality; ETOA; EEA; exoscopy; endoscopy; multi-portal approaches
(This special issue belongs to the Section Clinical Neurology)
Pain Management: Current Challenges and Future Prospects
edited by Gian Marco Petroni
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4527 | Submission Open
Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs
(This special issue belongs to the Section Anesthesiology)
Clinical Updates in Trauma and Emergency Medicine
edited by Yong-Soo Cho and Hyun Ho Ryu
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4499 | Submission Open
Keywords: emergency medicine; epidemiology; cardiovascular disease
(This special issue belongs to the Section Emergency Medicine)
Surgical Precision: The Impact of AI and Robotics in General Surgery
edited by Tamara M. H. Gall
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4328 | Submission Open
Keywords: robotic surgery; artificial intelligence in surgery; surgical training; AR in surgery; 3D imaging; surgical navigation
(This special issue belongs to the Section General Surgery)
Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques
edited by Francesco Coppolino and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4102 | Submission Open
Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management
(This special issue belongs to the Section Anesthesiology)
Recent Developments in Hearing and Balance Disorders: 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 3983 | Submission Open
Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance
(This special issue belongs to the Section Otolaryngology)
Clinical Progress of Spine Surgery
edited by and Gianluca Vadalà
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3845 | Submission Open
Keywords: spine surgery; rehabilitation; robotic surgery; spinal endoscopy; spinal tumor; back pain; minimally invasive surgery; spinal fusion
(This special issue belongs to the Section Clinical Neurology)
New Perspectives in Acute Coronary Syndrome
edited by Makoto Natsumeda
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3784 | Submission Open
Keywords: acute coronary syndrome; PCI; interventional cardiology; coronary imaging; antiplatelet therapy; stentless PCI strategy; CABG; revascularization
(This special issue belongs to the Section Cardiology)
Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes
edited by Filippo Carannante and Leandro Siragusa
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3650 | Submission Open
Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology
(This special issue belongs to the Section General Surgery)
Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia submission deadline 20 Feb 2026 | 1 articles | Viewed by 3576 | Submission Open
Keywords: cognition; dementia; rehabilitation; exercise; memory; physical activity; Alzheimer’ s disease; non-pharmacological therapies
(This special issue belongs to the Section Clinical Rehabilitation)
Acute Kidney Events in Intensive Care Patients
edited by Kada Klouche
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3565 | Submission Open
Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers
(This special issue belongs to the Section Intensive Care)
New Insights in the Diagnosis, Treatment and Monitoring of Anemia, Inflammation and Infection submission deadline 20 Feb 2026 | 2 articles | Viewed by 3469 | Submission Open
Keywords: anemia; inflammation; infection; diagnostic tools; therapeutic strategies
(This special issue belongs to the Section Hematology)
Management of Pregnancy Complications: 2nd Edition
edited by Ariel Many
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3332 | Submission Open
Keywords: high-risk pregnancy; preterm labor; fetal growth restriction; gestational diabetes; twins; hypertensive disorders during pregnancy; preeclampsia; IUGR; prenatal genetics; congenital anomaly detection; cesarean section; complications of labor and delivery
(This special issue belongs to the Section Obstetrics & Gynecology)
Kidney Transplantation: State of the Art Knowledge
edited by , Georgios Geropoulos and Kyriakos Psarras
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3308 | Submission Open
Keywords: kidney transplantation; end-stage renal disease; immunosuppression; organ donation; graft survival; graft rejection
(This special issue belongs to the Section Nephrology & Urology)
State of the Art in Invasive Vascular Interventions (Second Edition)
edited by and Luca Mezzetto
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3211 | Submission Open
Keywords: coronary artery interventions; non-coronary artery cardiac interventions; open surgical cardiac procedures; endo-vascular interventions; open surgical vascular procedures
(This special issue belongs to the Section Vascular Medicine)
Advances in Knee Surgery and Musculoskeletal Rehabilitation: 2nd Edition submission deadline 20 Feb 2026 | 1 articles | Viewed by 3155 | Submission Open
Keywords: computer-assisted surgical navigation; smart cutting guides; robotic-assisted surgery; fast-track; telemedicine; tele-rehabilitation; virtual reality
(This special issue belongs to the Section Orthopedics)
Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care
edited by and Thomas Kapapa
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3043 | Submission Open
Keywords: intracranial hypertension; cerebral perfusion pressure; decompressive craniectomy; brain tissue oxygenation; brain tissue microdialysis; blood brain barrier; neuro-critical care
(This special issue belongs to the Section Brain Injury)
Advances in Diagnosis and Therapeutic Strategies for Uveal Melanoma
edited by Yong Qin
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2978 | Submission Open
Keywords: uveal melanoma; immunotherapy; targeted therapy; biomarker; disease management; drug development; drug resistance
(This special issue belongs to the Section Ophthalmology)
Epidemiology of Hyperglycemia in Pregnancy and Its Maternofetal Adverse Outcomes
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 2863 | Submission Open
Keywords: gestational diabetes; diabetes in pregnancy; risk factors; epidemiology; maternofetal adverse outcomes in pregnancies with hypergliycemia; temporal trends
(This special issue belongs to the Section Endocrinology & Metabolism)
Global Expert Views on Clinical Aesthetic Plastic Surgery
edited by and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2743 | Submission Open
Keywords: aesthetic surgery; cosmetic surgery; dermal fillers; facial plastic surgery; soft tissue fillers; filler complications; ultrasound guided filler injection; hyaluronic acid filler
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice
edited by Ilaria Marcantoni and Michela Casella
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2674 | Submission Open
Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing
(This special issue belongs to the Section Cardiology)
Current Advances and Future Perspectives of Ischemic Stroke
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2434 | Submission Open
Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood– brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke
(This special issue belongs to the Section Clinical Neurology)
Thrombosis: Latest Advances and Prospects
edited by Manila Gaddh
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2424 | Submission Open
Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation
(This special issue belongs to the Section Hematology)
Pancreatitis: Current Perspectives on Diagnosis and Management
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2388 | Submission Open
Keywords: acute pancreatitis; chronic pancreatitis; pancreatitis; pancreatic cancer; eco-endoscopy; gallstones; biliary stones
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Neurological Rehabilitation: Innovations and Clinical Insights
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2310 | Submission Open
Keywords: rehabilitation; neurology; assessment; occupational therapy; disability; inclusion
(This special issue belongs to the Section Clinical Neurology)
Advanced Hysteroscopic Technology for Gynecological Disease submission deadline 20 Feb 2026 | 3 articles | Viewed by 2280 | Submission Open
Keywords: hysteroscopy; new technology; therapy; mini-invasive approach; laser; diagnosis; outcomes
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Updates in Stem Cell Transplants
edited by Daniele Avenoso and Michele Malagola
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2219 | Submission Open
Keywords: AML; CML; lymphoma; allo-HSCT; GVHD; MDS; AA
(This special issue belongs to the Section Hematology)
Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research
edited by , Arnaud Wattiez and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2167 | Submission Open
Keywords: endometriosis; guidelines; surgery; medical treatment; training; heuristics
(This special issue belongs to the Section Clinical Guidelines)
Current Trends and Future Challenges in Percutaneous Coronary Intervention
edited by Deniz Mutlu
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2052 | Submission Open
Keywords: PCI; IVUS; OCT; FFR; physiology; CT-guided PCI; complex PCI; CTO; bifurcation; coronary complications; mechanical circulatory support
(This special issue belongs to the Section Cardiovascular Medicine)
Integrating Psychological Science into Chronic Pain Management: Emerging Approaches and Insights
edited by Scott G. Ravyts and Margot De Kooning
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1898 | Submission Open
Keywords: chronic primary pain; nociplastic pain; coping strategies; depression; anxiety; trauma
(This special issue belongs to the Section Mental Health)
Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation
edited by Adriano Pellicelli
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1820 | Submission Open
Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Insights and Emerging Strategies in Chronic Pain Management
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1606 | Submission Open
Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care
(This special issue belongs to the Section Anesthesiology)
Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders submission deadline 20 Feb 2026 | 2 articles | Viewed by 1530 | Submission Open
Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science
(This special issue belongs to the Section Ophthalmology)
Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies submission deadline 20 Feb 2026 | 2 articles | Viewed by 1488 | Submission Open
Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT
(This special issue belongs to the Section Cardiology)
Breast Cancer: Symptoms, Types, Causes & Treatment
edited by Min-Jeong Cho and Sara Myers
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1471 | Submission Open
Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies
(This special issue belongs to the Section Obstetrics & Gynecology)
Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain submission deadline 20 Feb 2026 | 1 articles | Viewed by 1412 | Submission Open
Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain
(This special issue belongs to the Section Orthopedics)
Clinical Translation of Technological Innovations in Diabetes Therapeutics
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1255 | Submission Open
Keywords: diabetes management; remote patient monitoring (RPM); artificial intelligence (AI); machine learning (ML); wearable sensors; point-of-care diagnostics; centrifugal microfluidics; glucose monitoring
(This special issue belongs to the Section Endocrinology & Metabolism)
Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition submission deadline 20 Feb 2026 | 1 articles | Viewed by 1187 | Submission Open
Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis
(This special issue belongs to the Section Hematology)
Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1145 | Submission Open
Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation
(This special issue belongs to the Section Orthopedics)
New Insights in Cognitive Aging and Mild Cognitive Impairment submission deadline 20 Feb 2026 | 2 articles | Viewed by 1131 | Submission Open
Keywords: cognitive aging; mild cognitive impairment; normative aging; neuropsychological assessment; diagnosis; gerontology; prevention; intervention; multidisciplinary approach; measurement
(This special issue belongs to the Section Geriatric Medicine)
Current Opinion of Reconstructive and Aesthetic Breast Surgery
edited by , Konstantin Frank and Vanessa Brébant
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1130 | Submission Open
Keywords: reconstructive breast surgery; lipofilling; microsurgery; aesthetic breast surgery; PROM; digital anthropometry; autologous fat transfer; ADM; synthetic mesh; BIA-ALCL; BII
(This special issue belongs to the Section General Surgery)
Rising Star: Advanced Physical Therapy and Expansion
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 1109 | Submission Open
Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach
(This special issue belongs to the Section Clinical Rehabilitation)
Cancer Immunotherapy: Recent Advances and Clinical Challenges
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1077 | Submission Open
Keywords: immune checkpoint inhibitors; solid tumors; early-stage disease; metastatic disease; prognostic factors; biomarkers; resistance mechanisms
(This special issue belongs to the Section Oncology)
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