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Pancreatitis: Current Perspectives on Diagnosis and Management
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Pancreatitis: Current Perspectives on Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1623

Special Issue Editor

Dr. Alberto Maringhini

E-Mail Website
Guest Editor
Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Civico, 90127 Palermo, Italy
Interests: pancreatitis; acute pancreatitis; cirrhosis infections; internal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute pancreatitis occurred in over 17 million individuals in 2013, making it the 35th most common disease in the world, an incidence nearly twice that of acute myocardial infarction. In the United States, the annual incidence of acute pancreatitis is estimated to be approximately 40/100,000, resulting in over 130,000 new cases per year. Historically, acute pancreatitis has been considered an adult disease, but there is currently a strong interest in pediatric cases due to the increasing incidence and growing knowledge of acute pancreatitis in children. Recently, several studies on worldwide trends in acute pancreatitis have demonstrated an increase in incidence in both adult and child populations. These trends have been linked to a greater clinical awareness, increased diagnostic testing, and the rising prevalence of obesity. Although most patients with acute pancreatitis are admitted to hospital, it has recently been revealed that a discrete number of adult and children with mild acute pancreatitis are dismissed from the emergency department through an outpatient approach to therapy. This phenomenon reduces the incidence rate registered, leading to suspicions that the disease is much more diffuse than was previously believed. In the last decade, interventional endoscopy and interventional radiology have changed the therapeutic approach to severe acute pancreatitis, and new knowledge on epidemiology and risk factors has opened up innovative avenues in the prevention of this disease. Against this background, we invite you to submit your research to the Special Issue that we are proposing on acute pancreatitis.

Dr. Alberto Maringhini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute pancreatitis
  • chronic pancreatitis
  • pancreatitis
  • pancreatic cancer
  • eco-endoscopy
  • gallstones
  • biliary stones

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Published Papers (2 papers)

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Research

10 pages, 1372 KB  
Article
EUS Shear Wave Measurement for Early Chronic Pancreatitis: A Retrospective Diagnostic Accuracy Study Using the 2019 JPS Criteria
by Muneo Ikemura, Yusuke Takasaki, Koichi Ito, Akinori Suzuki, Yuka Fukuo, Hironao Okubo and Hiroyuki Isayama
J. Clin. Med. 2025, 14(20), 7349; https://doi.org/10.3390/jcm14207349 - 17 Oct 2025
Viewed by 180
Abstract
Background/Objectives: Diagnosis of early chronic pancreatitis (eCP) is important to prevent progression to established CP. Endoscopic ultrasonography (EUS) plays an important role in diagnosis; however, it is still difficult and has drawbacks in its inability to assess progression. EUS shear wave measurement (EUS-SWM) [...] Read more.
Background/Objectives: Diagnosis of early chronic pancreatitis (eCP) is important to prevent progression to established CP. Endoscopic ultrasonography (EUS) plays an important role in diagnosis; however, it is still difficult and has drawbacks in its inability to assess progression. EUS shear wave measurement (EUS-SWM) has been established to be a precise method for evaluating stiffness and the degree of fibrosis. This study aimed to evaluate the utility of EUS-SWM in eCP findings. Method: This study was retrospective, single center, and identified the 2019 Japan Pancreas Society (JPS) eCP criteria as the reference standard. We evaluated 38 patients who underwent EUS-SWM between April and November 2022. Patients were classified into positive EUS findings based on the JPS criteria for less than 2 (non-eCP finding group) and 2 or more (eCP finding group). The EUS-SWM value was compared between these groups and the relationship was analyzed with EUS findings. Result: Eleven of thirty-eight patients had eCP findings. The EUS-SWM value is significantly higher in the eCP finding group (2.39 ± 0.54 vs. 1.84 ± 0.46, p = 0.0065), and the EUS-SWM value is positively correlated with the number of positive EUS findings (r = 0.62, p < 0.001). The area under the receiver operating characteristic curve for EUS-SWM to distinguish the eCP finding group was 0.78 (0.62–0.95). The cut-off value of 1.87 showed sensitivity and specificity of 90.9% and 63.0%, respectively. Conclusions: EUS-SWM values correlate with EUS findings in eCP and may serve as an objective biomarker for disease progression. Full article
(This article belongs to the Special Issue Pancreatitis: Current Perspectives on Diagnosis and Management)
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17 pages, 5469 KB  
Article
Groove Pancreatitis in Focus: Tumor-Mimicking Phenotype, Diagnosis, and Management Insights
by Marina Balaban, Daniel Vasile Balaban, George Mănucu, Săndica Nicoleta Bucurică, Raluca Simona Costache, Florentina Ioniță-Radu, Mariana Jinga and Cristian Gheorghe
J. Clin. Med. 2025, 14(5), 1627; https://doi.org/10.3390/jcm14051627 - 27 Feb 2025
Viewed by 1058
Abstract
Background/Objectives: Groove pancreatitis (GP) is an uncommon pancreatic condition implying a challenging differential diagnosis. This study aims to comprehensively evaluate the main risk factors, clinical presentation, imaging and endoscopic characteristics of patients with GP, providing insights into an effective diagnostic approach and [...] Read more.
Background/Objectives: Groove pancreatitis (GP) is an uncommon pancreatic condition implying a challenging differential diagnosis. This study aims to comprehensively evaluate the main risk factors, clinical presentation, imaging and endoscopic characteristics of patients with GP, providing insights into an effective diagnostic approach and therapeutic strategies. Methods: A retrospective analysis was conducted on patients diagnosed with GP, with demographic and clinical data collected. The diagnostic route was followed by an upper endoscopy and was finally confirmed by cross-sectional imaging. In patients with high malignancy suspicion or with an uncertain diagnosis, a pancreatic endoscopic ultrasound (EUS) was further performed. According to imaging features, we divided patients into two categories: with and without tumor-like appearance. Results: Altogether, 23 patients were included, 11 in the tumor-like category, and 12 in the non-tumor-like group; 95.6% were men, 78.2% alcohol consumers, and 73.9% smokers. In both groups, the main symptom was abdominal pain, followed by nausea and vomiting. The most frequent finding at upper endoscopy was edematous duodenal mucosa (16 patients, 80%), followed by mucosal hyperemia (8 patients, 40%). The main finding at cross-sectional imaging was duodenal wall thickening (14 patients, 60.9%), followed by pancreatic head enlargement and duodenal wall cysts (both seen in 12 patients, 52.2%). The EUS predominantly showed duodenal wall thickening (13 patients, 68.4%), and intramural and paraduodenal cysts (10 patients, 52.6%). Conclusions: GP predominantly affects men with a history of chronic alcohol and tobacco use. Its primary diagnostic challenge lies in distinguishing it from pancreatic carcinoma, with an accurate diagnostic workup being crucial in clinical practice. Full article
(This article belongs to the Special Issue Pancreatitis: Current Perspectives on Diagnosis and Management)
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