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Pancreatitis: Current Perspectives on Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 677

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Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Civico, 90127 Palermo, Italy
Interests: pancreatitis; acute pancreatitis; cirrhosis infections; internal medicine
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Special Issue Information

Dear Colleagues,

Acute pancreatitis occurred in over 17 million individuals in 2013, making it the 35th most common disease in the world, an incidence nearly twice that of acute myocardial infarction. In the United States, the annual incidence of acute pancreatitis is estimated to be approximately 40/100,000, resulting in over 130,000 new cases per year. Historically, acute pancreatitis has been considered an adult disease, but there is currently a strong interest in pediatric cases due to the increasing incidence and growing knowledge of acute pancreatitis in children. Recently, several studies on worldwide trends in acute pancreatitis have demonstrated an increase in incidence in both adult and child populations. These trends have been linked to a greater clinical awareness, increased diagnostic testing, and the rising prevalence of obesity. Although most patients with acute pancreatitis are admitted to hospital, it has recently been revealed that a discrete number of adult and children with mild acute pancreatitis are dismissed from the emergency department through an outpatient approach to therapy. This phenomenon reduces the incidence rate registered, leading to suspicions that the disease is much more diffuse than was previously believed. In the last decade, interventional endoscopy and interventional radiology have changed the therapeutic approach to severe acute pancreatitis, and new knowledge on epidemiology and risk factors has opened up innovative avenues in the prevention of this disease. Against this background, we invite you to submit your research to the Special Issue that we are proposing on acute pancreatitis.

Dr. Alberto Maringhini
Guest Editor

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Keywords

  • acute pancreatitis
  • chronic pancreatitis
  • pancreatitis
  • pancreatic cancer
  • eco-endoscopy
  • gallstones
  • biliary stones

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Published Papers (1 paper)

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Research

17 pages, 5469 KiB  
Article
Groove Pancreatitis in Focus: Tumor-Mimicking Phenotype, Diagnosis, and Management Insights
by Marina Balaban, Daniel Vasile Balaban, George Mănucu, Săndica Nicoleta Bucurică, Raluca Simona Costache, Florentina Ioniță-Radu, Mariana Jinga and Cristian Gheorghe
J. Clin. Med. 2025, 14(5), 1627; https://doi.org/10.3390/jcm14051627 - 27 Feb 2025
Viewed by 496
Abstract
Background/Objectives: Groove pancreatitis (GP) is an uncommon pancreatic condition implying a challenging differential diagnosis. This study aims to comprehensively evaluate the main risk factors, clinical presentation, imaging and endoscopic characteristics of patients with GP, providing insights into an effective diagnostic approach and [...] Read more.
Background/Objectives: Groove pancreatitis (GP) is an uncommon pancreatic condition implying a challenging differential diagnosis. This study aims to comprehensively evaluate the main risk factors, clinical presentation, imaging and endoscopic characteristics of patients with GP, providing insights into an effective diagnostic approach and therapeutic strategies. Methods: A retrospective analysis was conducted on patients diagnosed with GP, with demographic and clinical data collected. The diagnostic route was followed by an upper endoscopy and was finally confirmed by cross-sectional imaging. In patients with high malignancy suspicion or with an uncertain diagnosis, a pancreatic endoscopic ultrasound (EUS) was further performed. According to imaging features, we divided patients into two categories: with and without tumor-like appearance. Results: Altogether, 23 patients were included, 11 in the tumor-like category, and 12 in the non-tumor-like group; 95.6% were men, 78.2% alcohol consumers, and 73.9% smokers. In both groups, the main symptom was abdominal pain, followed by nausea and vomiting. The most frequent finding at upper endoscopy was edematous duodenal mucosa (16 patients, 80%), followed by mucosal hyperemia (8 patients, 40%). The main finding at cross-sectional imaging was duodenal wall thickening (14 patients, 60.9%), followed by pancreatic head enlargement and duodenal wall cysts (both seen in 12 patients, 52.2%). The EUS predominantly showed duodenal wall thickening (13 patients, 68.4%), and intramural and paraduodenal cysts (10 patients, 52.6%). Conclusions: GP predominantly affects men with a history of chronic alcohol and tobacco use. Its primary diagnostic challenge lies in distinguishing it from pancreatic carcinoma, with an accurate diagnostic workup being crucial in clinical practice. Full article
(This article belongs to the Special Issue Pancreatitis: Current Perspectives on Diagnosis and Management)
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