Clinical Advances in Gastrointestinal Inflammation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 499

Special Issue Editor


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Guest Editor
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Split, Split, Croatia
2. Department of Health Studies, University of Split, Split, Croatia
Interests: gastrointestinal infections; Helicobacter pylori infections
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Special Issue Information

Dear Colleagues,

Gastrointestinal inflammation includes a wide spectrum of diseases from acute to chronic inflammatory processes of the gastrointestinal tract.

Helicobacter pylori is the most prevalent chronic bacterial infection, with approximately half of the world's population estimated to be colonized. Along with the worldwide antibiotic resistance trends, eradication rates are declining, while resistance rates of H. pylori are increasing, and eradication is becoming increasingly difficult.

For the above reasons, H. pylori is the most important gastrointestinal infection; therefore, this Special Issue, “Clinical Advances in Gastrointestinal Inflammation”, is specially dedicated to H. pylori infection. Following the COVID-19 pandemic and the widespread use of antibiotic therapies, we can expect new challenges in the treatment of H. pylori and the rise in antibiotic resistance.

In this Special Issue, we would like to emphasize the challenges of treating inflammatory bowel diseases, especially regarding the COVID-19 pandemic, which certainly had consequences for these patients during the pandemic. Therefore, research during the pandemic as well as in the post-COVID era is very important.

Research regarding acute gastrointestinal infections as well as celiac disease is welcome.

The suggested topics for this Special Issue are:

  • Challenges of treating H. pylori infection following the COVID-19 pandemic.
  • Challenges of treating inflammatory bowel diseases during and following the COVID-19 pandemic.
  • Challenges of treating acute gastrointestinal infections in the post-COVID era.
  • Challenges of treating celiac disease during and following the COVID-19 pandemic.
  • SARS-CoV-2-induced gastrointestinal diseases.

I hope that you will find the proposed topics suitable for this Special Issue, “Clinical Advances in Gastrointestinal Inflammation”, in JCM.

Dr. Ivana Jukic
Guest Editor

Manuscript Submission Information

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Keywords

  • Helicobacter pylori
  • antibiotic resistance
  • COVID-19 pandemic
  • post-COVID era
  • inflammatory bowel diseases
  • acute gastrointestinal infections
  • SARS-COV-2 infection
  • celiac disease

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Published Papers (1 paper)

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13 pages, 1214 KiB  
Article
Clinical Pathologic Profiles of Helicobacter pylori Reveal Age-Specific Peaking with Concomitant Chronic Gastric Inflammation, Robust Immunity, and Tissue Alterations Implying Potential Predisposition to Malignancy in Ha’il, Saudi Arabia
by Kamaleldin B. Said, Khalid F. Alshammari, Safia Moussa, Ruba M. Elsaid Ahmed, Ahmed H. Aljadani, Najd B. Albalawi, Layan Al-Hujaili, Ruaa Alharbi, Arwa A. Alotaibi, Fahad M. Alshammary, Fayez R. Alfouzan, Zaid A. Albayih, Bader I. Alkharisi, Ghadah N. Alsdairi and Shumukh H. Alshubrami
J. Clin. Med. 2025, 14(8), 2643; https://doi.org/10.3390/jcm14082643 - 11 Apr 2025
Viewed by 345
Abstract
Background/Objectives: Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic ulcers, and gastric malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarming rates of prevalence. This study aimed to elucidate local epidemiological [...] Read more.
Background/Objectives: Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic ulcers, and gastric malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarming rates of prevalence. This study aimed to elucidate local epidemiological patterns of H. pylori and examine its histopathological impact on the gastric mucosa. Methods: This retrospective-cross-sectional study included 805 symptomatic adults (329 males, 476 females) who underwent endoscopic evaluation at King Salman Hospital, Ha’il, Saudi Arabia. Biopsies from the antrum and body were processed using routine formalin fixation and paraffin embedding. Staining with hematoxylin–eosin (H&E) and Giemsa permitted assessment of chronic gastritis and detection of H. pylori. Data were evaluated by IBM SPSS (version 23, IBM Corp., Armonk, NY) for associations among infection, histopathology, and patient characteristics. Results: A total of 727 (90.3%) were H. pylori-positive with marginally higher rates in females (91.2%) than males (89.0%). Infection spanned all age groups, reaching 100% in males aged 60–80 years. Overall chronic GI complications were identified in 726 (99.9%), with chronic gastritis being the most profound histopathologically (19.3%). Lymphoid aggregates in 93.0% biopsies reflected a pronounced immune response. Advanced lesions, including metaplasia (0.8%), atrophy (0.3%), and lymphoma (0.1%), were uncommon, though indicative of potential malignant progression. Despite both sexes exhibiting universal symptoms of gastritis, dyspepsia, and heartburn, there were no statistically significant gender-based differences (p > 0.05); specifically, post-H. pylori signs such as vomiting, nausea, weight loss, bleeding or hematemesis occurred equally in all. Histopathology consistently revealed chronic active gastritis with glandular distortion, lymphoplasmacytic infiltration, and occasional mucosal erosions. Giemsa staining further confirmed abundant spiral shapes underscoring a high bacterial load. Conclusion: These findings highlight the age-specific persistently elevating rates of H. pylori significantly associated with chronic gastric inflammatory complications. Although advanced gastric lesions remain rare, reflecting regional epidemiology, early screening, and sleeve treatment efforts, the potential for malignant transformation makes it imperative for continued vigorous eradication, therapy, and vigilant follow-up to avert severe disease outcomes. Full article
(This article belongs to the Special Issue Clinical Advances in Gastrointestinal Inflammation)
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