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Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia
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Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Rehabilitation".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 310

Special Issue Editors

Dr. Blanca Gonzalez-Sanchez

E-Mail Website
Guest Editor
ADOLOR Research Group, Department of Medical-Surgical Therapy, Faculty of Medicine and Health Sciences, Extremadura University, 06006 Badajoz, Spain
Interests: cognition; episodic memory; exercise; memory; physical activity; rehabilitation; non-pharmacological therapies
Special Issues, Collections and Topics in MDPI journals
Dr. María Jiménez-Palomares

E-Mail Website
Guest Editor
ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine and Health Sciences Faculty, Extremadura University, 06006 Badajoz, Spain
Interests: cognition; episodic memory; exercise; memory; physical activity; rehabilitation; non-pharmacological therapies
Special Issues, Collections and Topics in MDPI journals
Dr. Juan Rodríguez-Mansilla

E-Mail
Guest Editor
ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine Faculty and Health Sciences, University of Extremadura, 06006 Badajoz, Spain
Interests: cognition; episodic memory; exercise; memory; physical activity; rehabilitation; non-pharmacological therapies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research shows that dementia and Alzheimer's are leading causes of the need for residential care in older adults. Estimates indicate that approximately 46 million people worldwide suffer from these conditions.

Medical evidence shows that both pharmacological and integrated non-pharmacological treatment, such as physical and cognitive rehabilitation, can improve the symptomatology of these patients, with a favorable impact on their quality of life.

For a forthcoming Special Issue of the Journal of Clinical Medicine (indexed in PubMed), we invite researchers to contribute original research articles (priority will be given to experimental studies) as well as review articles that stimulate continued efforts to better understand the relationship between rehabilitation and Alzheimer's disease and dementia.

Potential issues may include, but are not limited to:

  • The effects of exercise on Alzheimer's disease and dementia;
  • The effects of physical and cognitive rehabilitation on Alzheimer's disease and dementia;
  • New non-pharmacological therapies in the management of symptoms of Alzheimer's disease and dementia;
  • Multidisciplinary approaches to Alzheimer’s disease and dementia.

Dr. Blanca Gonzalez-Sanchez
Dr. María Jiménez-Palomares
Dr. Juan Rodríguez-Mansilla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cognition
  • dementia
  • rehabilitation
  • exercise
  • memory
  • physical activity
  • Alzheimer’s disease
  • non-pharmacological therapies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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17 pages, 550 KB  
Systematic Review
Cognitive Stimulation in Older Adults with Dementia: A Systematic Review
by María Jiménez-Palomares, Olga Montero-Barrero, Elisa María María Garrido-Ardila, Alicia Gibello-Rufo, Blanca González-Sánchez and Juan Rodríguez-Mansilla
J. Clin. Med. 2025, 14(20), 7225; https://doi.org/10.3390/jcm14207225 (registering DOI) - 13 Oct 2025
Abstract
Background: Dementia is a condition that affects the components of cognitive functions that are responsible for processing thought. There is no cure, but both pharmacological and non-pharmacological treatment helps to slow its progression. Presently, there is an increasing interest in non-pharmacological treatment, [...] Read more.
Background: Dementia is a condition that affects the components of cognitive functions that are responsible for processing thought. There is no cure, but both pharmacological and non-pharmacological treatment helps to slow its progression. Presently, there is an increasing interest in non-pharmacological treatment, including cognitive stimulation, which aims to improve the person’s preserved abilities in order to slow down the progression of the disease while maintaining the current state for as long as possible. The aim of this systematic review is to analyse the effects of cognitive stimulation in older people with dementia. Methods: This systematic review was conducted in the Pubmed, OTSeeker, ScienceDirect, Dialnet, and Scopus databases. The inclusion criteria were controlled trials, randomised and non-randomised clinical trials, and pilot studies that applied cognitive stimulation to older people with dementia or compared this therapy with another type of non-pharmacological intervention. Results: Twenty-one studies were included in the review. Most of the articles showed that the intervention group achieved better cognitive performance than the control group after completing the cognitive stimulation intervention. Four of the studies assessed caregivers and, in two of the them, improvements in the caregiver’s relationship with the person with dementia were achieved and the caregivers also improved their health-related quality of life. Conclusions: According to the results, cognitive stimulation does influence older adults with dementia, especially on cognitive functions. The results also indicate that cognitive stimulation can be beneficial for the caregivers because this therapy has positive effects on their quality of life as related to both their health and their relationship with the person with the disease. However, more research is needed, especially regarding the quality of life of patients with the disease. Full article
(This article belongs to the Special Issue Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia)
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