jcm-logo

Journal Browser

Journal Browser

Kidney Transplantation: State of the Art Knowledge

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1625

Special Issue Editors


E-Mail
Guest Editor
Department of General Surgery, Aneurin Bevan University Health Board, Newport, UK
Interests: transplantation; upper gastrointestinal surgery; endocrine surgery

E-Mail Website
Guest Editor
Department of General Surgery, Watford General Hospital, West Hertfordshire Teaching Hospitals, Watford WD18 0DH, UK
Interests: colorectal surgery; robotic surgery; transplantation; immunology

E-Mail Website
Guest Editor
2nd Department of Propaedeutic Surgery, Hippokration Hospital, School of Medicine, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
Interests: general surgery; upper digestive endocrine glands; colorectal cancer

Special Issue Information

Dear Colleagues,

Kidney transplantation remains the optimal treatment for end-stage renal disease, offering improved quality of life and survival compared to dialysis. Over the past decades, advancements in immunosuppression, surgical techniques, donor–recipient matching, and long-term graft monitoring have transformed kidney transplantation into a highly successful therapeutic intervention. Yet, persistent challenges—such as chronic rejection, organ shortages, and disparities in access—demand continued innovation and collaborative research.

This Special Issue, Kidney Transplantation: State of the Art Knowledge, aims to bring together leading experts to present the most current developments and critical perspectives in the field. Topics will include cutting-edge strategies for immunologic risk assessment, novel immunosuppressive therapies, approaches to expand the donor pool, and emerging technologies such as machine perfusion and biomarker-driven monitoring. Attention will also be given to ethical considerations, health equity, and the long-term care of transplant recipients.

Our aim is to provide clinicians, researchers, and policymakers with an authoritative resource that synthesizes the latest scientific and clinical insights, guiding the future of kidney transplantation practice. As the field evolves, so too must our approaches to ensure the best outcomes for patients worldwide.

Dr. Georgios Koimtzis
Dr. Georgios Geropoulos
Dr. Kyriakos Psarras
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney transplantation
  • end-stage renal disease
  • immunosuppression
  • organ donation
  • graft survival
  • graft rejection

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Other

11 pages, 1093 KB  
Systematic Review
Effect of Parathyroidectomy Timing on the Successful Resolution of Tertiary Hyperparathyroidism in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
by Ioannis Karniadakis, Leandros Stefanopoulos, Charalampos Balomenakis, Georgios Geropoulos, Kyriakos Psarras and Georgios Koimtzis
J. Clin. Med. 2025, 14(17), 5939; https://doi.org/10.3390/jcm14175939 - 22 Aug 2025
Viewed by 395
Abstract
Introduction: Tertiary hyperparathyroidism following kidney transplantation is a well-recognized complication in patients with pre-existing mineral imbalances due to chronic renal failure. Parathyroidectomy remains the only definitively curative option for tertiary hyperparathyroidism. The optimal timing of parathyroidectomy, before or after transplantation, is debated in [...] Read more.
Introduction: Tertiary hyperparathyroidism following kidney transplantation is a well-recognized complication in patients with pre-existing mineral imbalances due to chronic renal failure. Parathyroidectomy remains the only definitively curative option for tertiary hyperparathyroidism. The optimal timing of parathyroidectomy, before or after transplantation, is debated in the literature. This study aims to assess whether parathyroidectomy timing affects the successful resolution of tertiary hyperparathyroidism in patients with a functional kidney transplant. Methods: We conducted a systematic review and meta-analysis of the available literature collating the effect of pre- versus post-transplantation parathyroidectomy on the resolution of tertiary hyperparathyroidism. We compared the follow-up parathyroid hormone and calcium levels of patients subjected to either of these two approaches. Results: Three studies were identified, encompassing a total of 223 patients. The meta-analysis of available data yielded no statistically significant difference between pre- and post-kidney transplantation parathyroidectomy in terms of serum parathyroid hormone (SMD −0.19, 95% CI −0.92 to 0.55, p = 0.62) and calcium levels (SMD −0.75, 95% CI −2.30 to 0.80, p = 0.35). Conclusions: We demonstrated no significant difference between pre- and post-transplantation parathyroidectomy when it comes to the treatment of tertiary hyperparathyroidism. This meta-analysis is limited by the small number of studies included, reducing its statistical power. Therefore, additional studies are required to identify the optimal timing of intervention for the effective management of tertiary hyperparathyroidism in kidney transplant recipients. Full article
(This article belongs to the Special Issue Kidney Transplantation: State of the Art Knowledge)
Show Figures

Figure 1

15 pages, 807 KB  
Viewpoint
The New Horizon: A Viewpoint of Novel Drugs, Biomarkers, Artificial Intelligence, and Self-Management in Improving Kidney Transplant Outcomes
by Artur Quintiliano and Andrew J. Bentall
J. Clin. Med. 2025, 14(14), 5077; https://doi.org/10.3390/jcm14145077 - 17 Jul 2025
Viewed by 584
Abstract
The increasing prevalence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) has led to a growing demand for kidney transplantation (KTx). Identifying risk factors that enable improved allograft survival through novel therapeutic agents, advanced biomarkers, and artificial intelligence (AI)-driven data integration [...] Read more.
The increasing prevalence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) has led to a growing demand for kidney transplantation (KTx). Identifying risk factors that enable improved allograft survival through novel therapeutic agents, advanced biomarkers, and artificial intelligence (AI)-driven data integration are critical to addressing this challenge. Drugs, such as SGLT2 inhibitors and finerenone, have demonstrated improved outcomes in patients but lack comprehensive long-term evidence in KTx patients. The use of biomarkers, including circulating cytokines and transcriptomics, coupled with AI, could enhance early detection and personalized treatment strategies. Addressing patient self-management and addressing health access disparities may be more achievable using technologies used at home rather than traditional models of healthcare and thus lead to increased transplant success, both in terms of transplantation rates and allograft longevity. Full article
(This article belongs to the Special Issue Kidney Transplantation: State of the Art Knowledge)
Show Figures

Figure 1

Back to TopTop