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JCM
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Management of Pregnancy Complications: 2nd Edition
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Management of Pregnancy Complications: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 2233

Special Issue Editor

Prof. Dr. Ariel Many

E-Mail Website
Guest Editor
1. Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak 51544, Israel
2. Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Interests: high-risk pregnancy; preterm labor; fetal growth restriction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue on the “Management of Pregnancy Complications: 2nd Edition”, which follows the success of the first volume, comprising 10 papers. For more details, please visit https://www.mdpi.com/journal/jcm/special_issues/50P73F5MQB.

We are seeking papers on the topic of high-risk pregnancies, complications, and innovative treatments. In these pregnancies, the mother, the fetus, or both are at increased risk of complications or adverse outcomes, including preterm labor, preeclampsia, diabetes, fetal growth restriction, and many other medical and environmental conditions.

We welcome original research articles, reviews, case reports, and perspectives on any aspect of high-risk pregnancies, including (but not limited to) the following:

  • Identification and management of high-risk pregnancies;
  • Predictive factors for adverse outcomes in high-risk pregnancies;
  • Novel diagnostic tools and interventions for high-risk pregnancies;
  • Innovative genetic and other fetal diagnostic tools;
  • Long-term outcomes for mothers and babies after high-risk pregnancies;
  • High-risk deliveries, complications, and treatments;
  • Ethical considerations in managing high-risk pregnancies.

We welcome submissions from obstetricians, gynecologists, maternal-fetal medicine specialists, neonatologists, geneticists, endocrinologists, epidemiologists, and other researchers interested in high-risk pregnancies.

All submitted papers will undergo a rigorous peer-review by our expert reviewer panel before being published in this Special Issue. We look forward to receiving your contributions.

Prof. Dr. Ariel Many
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • high-risk pregnancy
  • preterm labor
  • fetal growth restriction
  • gestational diabetes
  • twins
  • hypertensive disorders during pregnancy
  • preeclampsia
  • IUGR
  • prenatal genetics
  • congenital anomaly detection
  • cesarean section
  • complications of labor and delivery

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Related Special Issue

Published Papers (2 papers)

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Research

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17 pages, 880 KB  
Article
Dysregulation of Treg/Th17 Balance and Intracellular Expression of IL-21 and IL-22 in the Pathogenesis of Gestational Hypertension
by Maciej Kwiatek, Wojciech Kwaśniewski, Tomasz Gęca, Ewelina Grywalska, Mansur Rahnama-Hezavah, Sebastian Mertowski, Tomasz Urbanowicz, Magdalena Ewa Kowalkowska, Maciej Krasiński, Anna Kwaśniewska and Maciej Brązert
J. Clin. Med. 2025, 14(20), 7288; https://doi.org/10.3390/jcm14207288 - 15 Oct 2025
Viewed by 375
Abstract
Background/Objectives: Pregnancy-induced hypertension (PIH), including preeclampsia (PE), remains a significant cause of maternal and fetal morbidity. Immune imbalance involving T helper (Th17) and regulatory T (Treg) cells is increasingly recognized as contributing to the pathogenesis of PIH. This study aimed to assess the [...] Read more.
Background/Objectives: Pregnancy-induced hypertension (PIH), including preeclampsia (PE), remains a significant cause of maternal and fetal morbidity. Immune imbalance involving T helper (Th17) and regulatory T (Treg) cells is increasingly recognized as contributing to the pathogenesis of PIH. This study aimed to assess the proportions of Th17 and Treg cells and intracellular cytokine expression (IL-17A, IL-17F, IL-21, and IL-22) in the peripheral blood of hypertensive versus normotensive pregnant women. Methods: A total of 108 pregnant women were included: 60 with hypertensive disorders and 48 normotensive controls. Peripheral blood mononuclear cells were analyzed using multiparametric flow cytometry to quantify CD4+CD25+FoxP3+ Treg and CD4+IL-17A+ Th17 cells, along with intracellular IL-17F, IL-21, and IL-22 co-expression. Correlations with clinical and obstetric parameters were evaluated. Results: Hypertensive patients showed significantly increased proportions of activated Th17 cells (CD4+IL-17A+) and Th17 subpopulations co-expressing IL-17F and IL-22, as well as IL-21 and IL-22 (p < 0.0001). Although Treg cell percentages were lower in the hypertensive group, the difference was not statistically significant. A pronounced Th17/Treg imbalance was observed. Positive correlations were found between Th17 subpopulations and gestational age, birth weight, and length, as well as maternal age. Conclusions: The immune profile in hypertensive pregnancies was characterized by a shift toward Th17-mediated proinflammatory responses, supporting the role of immune dysregulation in PIH. The increased frequency of Th17 cells co-expressing IL-21 and IL-22 may serve as a potential biomarker of disease severity and warrants further exploration. Full article
(This article belongs to the Special Issue Management of Pregnancy Complications: 2nd Edition)
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Other

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20 pages, 1529 KB  
Systematic Review
Pregnancy-Related Acute Kidney Injury: Causes and Its Impact on Perinatal Outcomes—A Systematic Review
by Emmanuel N. Kontomanolis, Ioannis Prokopakis, Antonios Koutras, Emmanouil Andreou, Dionysios Metaxas, Gerasimos Boulieris, Eleftherios Zachariou, Ioakeim Sapantzoglou, Dimitrios Papageorgiou, Vasileios-Chrysovalantis Palios, Charalampos Karachalios, Angeliki Papadimitriou, Konstantinos Daglas, Athanasios Chionis, Antonios Lagadas and Paraskevas Perros
J. Clin. Med. 2025, 14(17), 6031; https://doi.org/10.3390/jcm14176031 - 26 Aug 2025
Viewed by 1536
Abstract
Background: Pregnancy-Related Acute kidney injury (PRAKI) is a critical complication of pregnancy, defined by the sudden deterioration in renal function during gestation or within the initial six weeks postpartum. Pregnancy is thought to increase the risk of acute kidney injury (AKI) by 51%. [...] Read more.
Background: Pregnancy-Related Acute kidney injury (PRAKI) is a critical complication of pregnancy, defined by the sudden deterioration in renal function during gestation or within the initial six weeks postpartum. Pregnancy is thought to increase the risk of acute kidney injury (AKI) by 51%. This is linked to the anatomical alterations that occur during pregnancy and special conditions, such as preeclampsia/eclampsia. PRAKI’s epidemiology and outcome vary between developed and developing nations. PRAKI is an uncommon entity in high-income countries; however, its incidence has recently increased. The aim of this systematic review is to evaluate the maternal and perinatal outcomes and risk factors affecting pregnancies affected by AKI. Methods: Comprehensive research was performed in PubMed/Medline, Scopus, and Google Scholar electronic databases from 2015 up to January 2025, using the terms AKI, PRAKI, sepsis, preeclampsia/eclampsia, liver enzymes, low platelet count (HELLP) syndrome, and pregnancy. After a thorough assessment, 25 full-text articles were obtained. Results: Our results revealed that preeclampsia, eclampsia, HELLP syndrome, and antepartum and postpartum hemorrhage predispose women to PRAKI. Other unusual factors, like disseminated intravascular coagulation (DIC) or hemolytic uremic syndrome (HUS), should not be underestimated. Furthermore, the latest published data showed unfavorable maternal and fetal outcomes in pregnancies affected by AKI compared to the general population. Conclusions: PRAKI constitutes a serious pregnancy complication that requires immediate treatment. The higher prevalence of PRAKI in developing countries (4–26%) versus wealthy nations (1.0–2.8%) has considerably indicated the impact of socioeconomic status and the accessibility of health services. Full article
(This article belongs to the Special Issue Management of Pregnancy Complications: 2nd Edition)
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