Current Trends and Future Challenges in Percutaneous Coronary Intervention

Dear Colleagues,

The field of percutaneous coronary intervention (PCI) continues to evolve rapidly, driven by advances in imaging technologies, device innovations, and procedural techniques. Contemporary PCI strategies now offer enhanced precision in lesion assessment and stent deployment, significantly improving patient outcomes. Developments such as intravascular imaging (IVUS, OCT), physiology-guided PCI, and the use of drug-coated balloons are expanding the boundaries of what is achievable in coronary intervention.

Additionally, the treatment of complex coronary lesions—such as chronic total occlusions, bifurcation lesions, and left main disease—has become increasingly feasible, supported by dedicated tools and techniques. The integration of artificial intelligence and robotic-assisted PCI is also beginning to shape the future landscape of interventional cardiology.

Despite these advances, several challenges remain. These include addressing long-term outcomes in high-risk populations, optimizing antithrombotic therapy to balance ischemic and bleeding risks, and improving access to PCI in resource-limited settings. Moreover, the clinical integration of novel technologies and techniques must be guided by robust evidence to ensure safety and efficacy.

In this Special Issue, we invite authors to contribute original research and review articles on the latest clinical advances in PCI, focusing on innovations, unresolved questions, and future directions in the diagnosis and interventional treatment of coronary artery disease.

Dr. Deniz Mutlu
Guest Editor

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