Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care

Dear Colleagues,

Despite advances in our understanding of the pathophysiology of secondary or delayed brain injury, in pre-hospital care, surgical management and intensive care treatments, there are still significant clinical, epidemiological and demographic challenges. The mean age of people with traumatic brain injury (TBI) is increasing in many high-income countries. However, there are currently no guidelines for treating TBI in elderly patients. Conversely, many middle- and low-income countries have a rapidly growing population of young TBI patients requiring treatment in under-resourced structures. Understanding and treating increased intracranial pressure, oedema formation, blood-brain barrier breakdown, cell metabolism, extracranial organ function, inflammatory processes and decompressive craniectomy remain controversial issues, especially in children.

Last year, we celebrated the 50th anniversary of the introduction of the Glasgow Coma Scale. It remains the most widely used method of assessing the severity of TBI based on level of consciousness. In the 21st century, however, questions have been raised as to whether this classification of severity, identification of patients at risk, assignment to special treatment procedures, and assessment of prognosis are still sufficient. Today, clinical, cellular, molecular-genetic and radiological biomarkers offer promising additions.

To further support interdisciplinary scientific discussion in this field, we invite basic scientists and clinicians to publish new findings from translational preclinical research integrating standard therapeutic measures into the experimental design, and new therapeutic approaches in our special issue. The aim is to minimise the gap between the bench and bedside in the field of TBI.

Prof. Dr. Peter Radermacher
Prof. Dr. Thomas Kapapa
Guest Editors

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