Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Brain Injury".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 34
Special Issue Editors
2. Service de Médecine Intensive-Réanimation et Médecine Hyperbare, Centre Hospitalier Universitaire, Angers, France
Interests: traumatic-haemorrhagic shock; sepsis and septic shock; traumatic brain injury; animal modeling; diving and hyperbaric medicine
Special Issues, Collections and Topics in MDPI journals
Interests: traumatic brain injury; secondary brain injury; stroke; subarachnoid hemorrhage; neuro-critical care; blood-brain-barrier; neurorehabilitation; spinal cord injury
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite advances in our understanding of the pathophysiology of secondary or delayed brain injury, in pre-hospital care, surgical management and intensive care treatments, there are still significant clinical, epidemiological and demographic challenges. The mean age of people with traumatic brain injury (TBI) is increasing in many high-income countries. However, there are currently no guidelines for treating TBI in elderly patients. Conversely, many middle- and low-income countries have a rapidly growing population of young TBI patients requiring treatment in under-resourced structures. Understanding and treating increased intracranial pressure, oedema formation, blood-brain barrier breakdown, cell metabolism, extracranial organ function, inflammatory processes and decompressive craniectomy remain controversial issues, especially in children.
Last year, we celebrated the 50th anniversary of the introduction of the Glasgow Coma Scale. It remains the most widely used method of assessing the severity of TBI based on level of consciousness. In the 21st century, however, questions have been raised as to whether this classification of severity, identification of patients at risk, assignment to special treatment procedures, and assessment of prognosis are still sufficient. Today, clinical, cellular, molecular-genetic and radiological biomarkers offer promising additions.
To further support interdisciplinary scientific discussion in this field, we invite basic scientists and clinicians to publish new findings from translational preclinical research integrating standard therapeutic measures into the experimental design, and new therapeutic approaches in our special issue. The aim is to minimise the gap between the bench and bedside in the field of TBI.
Prof. Dr. Peter Radermacher
Prof. Dr. Thomas Kapapa
Guest Editors
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Keywords
- intracranial hypertension
- cerebral perfusion pressure
- decompressive craniectomy
- brain tissue oxygenation
- brain tissue microdialysis
- blood brain barrier
- neuro-critical care
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