Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 26
Special Issue Editor
Interests: liver diseases; cirrhosis; liver transplantation; hepatocellular carcinoma; liver cirrhosis; hepatitis; liver failure; infectious diseases; internal medicine; liver diseases and immunology
Special Issue Information
Dear Colleagues,
In recent years, the management of hepatocellular carcinoma (HCC) has undergone a profound transformation thanks to the introduction of immunotherapy and combined treatments involving locoregional approaches. This Special Issue aims to explore the most innovative and personalized strategies in the treatment of HCC and liver transplantation, with particular focus on patients in BCLC-B and BCLC-C stages. For BCLC-B patients, the therapeutic goal is shifting from simple disease control to downstaging toward resection or liver transplantation through the use of TACE or TARE alone or combined with immunotherapy. In BCLC-C patients, different clinical scenarios emerge: in cases with extrahepatic spread, the goal remains prolonging survival, while in those with vascular invasion, surgical downstaging may be possible in selected cases. Special attention is also given to the evolution of transplant criteria beyond the Milan criteria and to assessing the risk of post-transplant recurrence. Additional topics include clinical and biological selection of candidates, treatment response as a prognostic marker, and future perspectives in precision medicine, including genomic profiling and the use of biomarkers. This Special Issue aspires to provide an updated and multidisciplinary overview of HCC in the era of personalized therapy.
Dr. Adriano Pellicelli
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hepatocellular carcinoma
- transarterial chemoembolization (TACE)
- transarterial radioembolization (TARE)
- liver transplant
- immune checkpoint inhibitors (ICI)
- tyrosine kinase inhibitor
- liver function assessment
- Child-Pugh score
- bridging to liver transplantation
- immuno escape
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
