Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research

Dear Colleagues,

The first goal of this Special Issue will be to explore how the evidence-based management of endometriosis [1] can be updated by collective clinical experience [2,3]. This is important since, for endometriosis, evidence is limited in the absence of a suitable animal model. Also, most clinical decisions are multivariate, which conflicts with monovariate trial evidence. This is especially important for surgery.

Therefore, all clinicians with extensive experience in managing endometriosis are invited to suggest and their plans in their specific area of their expertise in diagnosis or treatment. The collective experience of the authors will reflect the strength of the recommendations. This also permits us to discuss what should not be performed [4], or how skills and heuristics should be trained.

The second goal is to highlight new research findings that should be brought to the attention of clinicians. This is important to fill the gap between clinicians and surgeons with a large clinical load and important laboratory research. This is important since both groups, living in different information environments, can learn from each other.

This Special Issue will be the first attempt to formulate clinical guidelines based on collective expert opinion and to expose clinical needs and researchers’ opportunities.

Reference List

1. Becker, C.M.; Bokor, A.; Heikinheimo, O.; Horne, A.; Jansen, F.; Kiesel, L.; King, K.; Kvaskoff, M.; Nap, A.; Petersen, K.; et al. ESHRE guideline: endometriosis. Hum Reprod Open 2022, 2022, hoac009, doi:10.1093/hropen/hoac009.
2. Koninckx, P.R.; Ussia, A.; Stepanian, A.; Saridogan, E.; Malzoni, M.; Miller, C.E.; Keckstein, J.; Wattiez, A.; Page, G.; Bosteels, J.; et al. The Evidence-Based Medicine Management of Endometriosis Should Be Updated for the Limitations of Trial Evidence, the Multivariability of Decisions, Collective Experience, Heuristics, and Bayesian Thinking. Journal of Clinical Medicine 2025, 14, 248, doi:10.3390/jcm14010248.
3. Koninckx, P.R.; Ussia, A.; Miller, C.; Guo, S.-W.; Lesaffre, E.; Wattiez, A.; Adamyan, L. How to bridge the gap between evidence-based and clinical management of endometriosis. Journal of Endometriosis and Uterine Disorders 2025, 100123.
4. Koninckx, P.R.; Ussia, A.; Gordts, S.; Keckstein, J.; Saridogan, E.; Malzoni, M.; Stepanian, A.; Setubal, A.; Adamyan, L.; Wattiez, A. The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach. J Clin Med 2023, 12, 4547, doi:10.3390/jcm12134547.

Prof. Dr. Philippe R. Koninckx
Guest Editor

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• endometriosis
• guidelines
• surgery
• medical treatment
• training
• heuristics