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New Insights in the Diagnosis, Treatment and Monitoring of Anemia, Inflammation and Infection

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 829

Special Issue Editor


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Guest Editor
1. Department of Anaesthesia, St. Marienhospital Vechta, Marienstraße 6-8, 49377 Vechta, Germany
2. Department of Anesthesiology and Critical Care, University Hospital of Muenster, Münster, Germany
Interests: anemia; anesthesia; patient blood management; intensive care; mechanical ventilation; resuscitation

Special Issue Information

Dear Colleagues,

Anemia, inflammation, and infection represent interconnected clinical challenges that significantly impact patient outcomes across various medical fields. Recent advancements in diagnostic tools, therapeutic strategies, and monitoring technologies have opened new avenues for addressing these conditions more effectively. However, a comprehensive and integrative approach is crucial to bridge the gaps in current practice and improve patient care.

This Special Issue calls for collaborative efforts to explore and implement innovative approaches in the diagnosis, treatment, and monitoring of anemia, inflammation, and infection. Emerging diagnostic modalities, including next-generation biomarkers and advanced imaging techniques, offer unprecedented accuracy and early detection capabilities. Therapeutic innovations, such as targeted biological agents and gene therapies, hold promise in addressing the underlying mechanisms of these conditions rather than merely alleviating symptoms. Furthermore, advancements in digital health technologies, including wearable devices and AI-driven analytics, provide real-time insights into patient status, enabling personalized and dynamic treatment adjustments.

Interdisciplinary research and clinical trials are essential to validate these innovations and assess their impact on long-term outcomes. Additionally, addressing disparities in access to these advancements is vital to ensure equitable healthcare. This appeal emphasizes the urgency of global collaboration among clinicians, researchers, policymakers, and industry leaders to translate scientific progress into tangible improvements in patient care.

By fostering innovation and integration, we can redefine the standards of care for anemia, inflammation, and infection, ultimately enhancing quality of life and reducing the global burden of these conditions. Let us seize this opportunity to shape a future where science and compassion converge for better health outcomes worldwide.

Prof. Dr. Christian Hönemann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anemia
  • inflammation
  • infection
  • diagnostic tools
  • therapeutic strategies

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Published Papers (1 paper)

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Review

28 pages, 4044 KB  
Review
Endotoxin’s Impact on Organism: From Immune Activation to Tolerance and Beyond
by Kacper Roszak, Konkonika Roy, Justyna Sobocińska, Paulina Spisz, Tomasz Jędrzejewski and Sylwia Wrotek
J. Clin. Med. 2025, 14(18), 6478; https://doi.org/10.3390/jcm14186478 - 14 Sep 2025
Viewed by 497
Abstract
Endotoxin, a key component of Gram-negative bacterial membranes, remains a central focus in understanding host–pathogen interactions and immune modulation. In this review, we examine the multifaceted roles of endotoxin, with particular emphasis on how its structural variants modulate host immune recognition and inflammatory [...] Read more.
Endotoxin, a key component of Gram-negative bacterial membranes, remains a central focus in understanding host–pathogen interactions and immune modulation. In this review, we examine the multifaceted roles of endotoxin, with particular emphasis on how its structural variants modulate host immune recognition and inflammatory signalling. We explore the complex mechanisms by which endotoxin activates innate immune pathways and how these responses evolve under repeated or chronic exposure conditions. Special attention is given to the phenomenon of endotoxin tolerance, an adaptive reprogramming of immune cells that can profoundly alter inflammatory outcomes. While this tolerance serves as a protective mechanism against hyperinflammation, mounting evidence suggests that it may have a “dark side”, potentially impairing immune surveillance and promoting disease states such as cancer. We also discuss emerging clinical and therapeutic strategies that harness or counteract endotoxin-driven responses, from vaccine adjuvants to anti-sepsis interventions. By integrating recent findings from immunology, microbiology, and translational medicine, this review sheds light on the dual nature of endotoxin and its far-reaching implications for human health. Full article
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