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Clinical Trends in Cardiomyopathy
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Clinical Trends in Cardiomyopathy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 584

Special Issue Editor

Dr. Giulia Iannaccone

E-Mail Website
Guest Editor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Interests: clinical cardiology; echocardiography; heart failure

Special Issue Information

Dear Colleagues,

Remarkable progress has been made in the cardiomyopathy field over the past few decades, revolutionizing every step, from diagnosis to treatment. For starters, knowledge of the genetic background has significantly spread, allowing for the prompt adoption of preventive strategies for family members of probands. Moreover, the incredible technological improvements have increased the diagnostic sensibility of various imaging modalities. In particular, multimodality imaging has proven to be of the utmost importance to detect early cardiac manifestations of cardiomyopathies, thanks to novel technologies like speckle tracking imaging in echocardiography and tissue characterization in cardiac magnetic resonance. Moreover, multimodality imaging is also essential to evaluate disease progression and, in some cases, assess treatment efficacy. In addition, bone myocardial scintigraphy may avoid endomyocardial biopsy in the diagnostic pathway of wild-type transthyretin cardiac amyloidosis. Finally, targeted therapies for specific types of cardiomyopathies are now available, and more are expected to be developed and implemented in the years to come. In this Special Issue, we welcome authors to submit papers on clinical trends in cardiomyopathies in terms of both diagnosis and treatment.

Dr. Giulia Iannaccone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiomyopathy
  • genetics
  • treatment
  • targeted therapy
  • prognosis
  • long-term follow up

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Published Papers (1 paper)

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Research

13 pages, 2627 KiB  
Article
Declining Myocarditis Mortality in the United States and the Impact of the COVID-19 Pandemic
by Ali Bin Abdul Jabbar, Daniyal Ali Khan, John Osborne, William Thomson, Ameya Chinawalkar, Mason Klisares, Kyle Gilkeson and Ahmed Aboeata
J. Clin. Med. 2025, 14(14), 5116; https://doi.org/10.3390/jcm14145116 - 18 Jul 2025
Viewed by 390
Abstract
Background: Myocarditis is associated with increased mortality due to complications such as cardiogenic shock and arrhythmia. Trends of myocarditis-related mortality in the United States, along with demographic and regional disparities and changes during the COVID-19 pandemic, are unknown. Methods: We used the Centers [...] Read more.
Background: Myocarditis is associated with increased mortality due to complications such as cardiogenic shock and arrhythmia. Trends of myocarditis-related mortality in the United States, along with demographic and regional disparities and changes during the COVID-19 pandemic, are unknown. Methods: We used the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database to extract data for myocarditis deaths from 1999 to 2023. The Joinpoint Regression Program was used to analyze long-term trends in mortality, and R Studio (version 4.4.1) was used to calculate expected and excess mortality for 2020 to 2023. Results: There were 33,016 myocarditis-related deaths from 1999 to 2023. The age-adjusted mortality rate (AAMR) of myocarditis deaths decreased by 46.08% from 7.40 (95% CI: 7.04–7.76) in 1999 to 3.99 (95% CI: 3.74–4.23) in 2019, with an APC of −2.59 (95% CI: −2.97 to −2.24). From 2019 to 2021, the AAMR increased by 46.62% to 5.85 (95% CI: 5.56–6.14) by 2021 (2019–2021 APC 22.3%*), reversing the gains of the previous two decades. By 2023, the AAMR recovered to 4.33 (95% CI: 4.09 to 4.58), though mortality was still higher than expected from pre-pandemic trends. From 2020 to 2023, there were 40.12% more deaths than expected, with 54.94% higher mortality in 2021. Briefly, 70.33% of excess myocarditis-related deaths also had COVID-19, with a peak of 76.15% of excess myocarditis deaths in 2021 being reported as involving COVID-19 infection. Significant disparities in mortality trends persisted, with males, NH Black or African Americans, and the elderly having higher mortality rates. Conclusions: Myocarditis mortality decreased in the United States from 1999 to 2019 but significantly increased during the COVID-19 pandemic years 2020 and 2021. At the height of the pandemic, COVID-19 infection contributed to almost three-quarters of excess myocarditis mortality. Significant disparities in myocarditis mortality persisted from 1999 to 2023. Full article
(This article belongs to the Special Issue Clinical Trends in Cardiomyopathy)
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