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Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes
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Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 583

Special Issue Editors

Dr. Filippo Carannante

E-Mail Website
Guest Editor
Colorectal Surgery Unit, Campus Bio-Medico University Hospital, Via Álvaro del Portillo, 200, 00128 Rome, Italy
Interests: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology
Dr. Leandro Siragusa

E-Mail Website
Guest Editor
Division of Colon and Rectal Surgery, Humanitas Research Hospital, Via Alessandro Manzoni, 56, 20089 Rozzano, Italy
Interests: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology

Special Issue Information

Dear Colleagues,

Colorectal surgery has experienced rapid advancements in recent years, with newer technologies and techniques increasingly becoming part of surgical practice. However, there are still many areas in coloproctology that remain underexplored, and the drive to clarify these uncertainties continues to grow, alongside the integration of innovations into clinical practice. The aim of this Special Issue is to provide a platform for critically evaluating how recent technological developments have influenced colorectal surgery outcomes, perioperative patient management, postoperative recovery, and the overall patient experience during surgery. Manuscripts are invited that critically assess the role of minimally invasive approaches, the application of artificial intelligence and big data in decision-making, perioperative patient optimization, the use of translational research in coloproctology, or the comparison of outcomes between various innovative approaches to colorectal diseases. Priority will be given to high-quality original studies and well-designed and conducted systematic reviews or meta-analyses that offer a concise and comprehensive overview of the current state of the art on a specific topic.

Dr. Filippo Carannante
Dr. Leandro Siragusa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal surgery
  • minimally invasive techniques
  • artificial intelligence
  • perioperative patient management
  • translational research in coloproctology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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17 pages, 2202 KiB  
Systematic Review
C-Reactive Protein in Peritoneal Fluid for Predicting Anastomotic Leakage After Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis
by Tharith Vun, Zhanghao Wu, Chetra Chea, Weidong Liu, Ran Tao and Youming Deng
J. Clin. Med. 2025, 14(6), 2099; https://doi.org/10.3390/jcm14062099 - 19 Mar 2025
Viewed by 443
Abstract
Background: Anastomotic leakage (AL) is a serious and potentially fatal complication that can occur after colorectal cancer (CRC) surgery, and it significantly affects patient recovery and increases morbidity. While serum C-reactive protein (CRP) is a recognized systemic inflammatory marker, the level of [...] Read more.
Background: Anastomotic leakage (AL) is a serious and potentially fatal complication that can occur after colorectal cancer (CRC) surgery, and it significantly affects patient recovery and increases morbidity. While serum C-reactive protein (CRP) is a recognized systemic inflammatory marker, the level of CRP in peritoneal fluid may serve as a more specific and localized biomarker for early AL detection. This meta-analysis explores the diagnostic potential of peritoneal fluid CRP, aiming to enhance postoperative care for CRC patients. Methods: A comprehensive literature search was conducted following the PRISMA guidelines. Eligible studies were included based on strict inclusion and exclusion criteria. Diagnostic accuracy was pooled using a random-effects model. The risk of bias was assessed using the QUADAS-2 tool. Results: The pooled sensitivity and specificity were 0.74 and 0.83, respectively, with an area under the curve (AUC) of 0.84, indicating good diagnostic accuracy. The overall diagnostic performance was consistent for sensitivity with no significant heterogeneity, but high heterogeneity was observed for specificity, suggesting variability between studies. Subgroup analysis revealed improved diagnostic performance between postoperative days 5–7 and higher CRP cut-off values (70–150 mg/L). The analysis confirmed the stability of the results through a sensitivity analysis and found no significant publication bias. Conclusions: Peritoneal fluid CRP is a reliable biomarker for detecting AL after CRC surgery, especially in the later postoperative period. However, heterogeneity in study methodologies and patient populations limits the generalizability of the findings. Future research should focus on standardizing protocols and exploring additional biomarkers to improve diagnostic accuracy. Full article
(This article belongs to the Special Issue Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes)
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