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New Perspectives in Acute Coronary Syndrome
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New Perspectives in Acute Coronary Syndrome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 563

Special Issue Editor

Dr. Makoto Natsumeda

E-Mail Website
Guest Editor
Department of Cardiovascular Medicine, Ikegami General Hospital, 6-1-19 Ikegami, Ota-ku, Tokyo 146-8531, Japan
Interests: PCI; interventional cardiology; acute coronary syndrome; heart failure

Special Issue Information

Dear Colleagues,

We invite researchers and clinicians to contribute original research, reviews, and perspectives to our Special Issue, “New Perspectives in Acute Coronary Syndrome (ACS)”. It aims to spotlight cutting-edge advancements in understanding, diagnosing, and managing ACS. Topics of interest include innovative therapeutic strategies (i.e., stentless PCI (percutaneous coronary intervention), excimer laser, and perfusion balloon), precision medicine approaches such as antithrombotic regimens and their durations, emerging technologies in imaging and diagnostics, and the role of artificial intelligence in patient care. We also welcome studies addressing revascularization strategies such as complete versus incomplete revascularization, as well as their timing after onset, and methods focusing on PCI and CABG (Coronary Artery Bypass Grafting). Special populations, such as the elderly, frail, and cancer patients, and balancing invasive approaches with risks are also areas of interest. By fostering interdisciplinary collaboration, this Special Issue seeks to advance the field and improve patient outcomes. Submit your work to join a global dialogue shaping the future of ACS management.

Dr. Makoto Natsumeda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndrome
  • PCI
  • interventional cardiology
  • coronary imaging
  • antiplatelet therapy
  • stentless PCI strategy
  • CABG
  • revascularization

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

32 pages, 1295 KB  
Review
Dyslipidemia Treatment in Patients with Acute Coronary Syndrome: Is It Time to Move to Combination Therapy?
by Daniel Miron Brie, Cristian Mornoș, Ovidiu Adam, Alexandru Tîrziu and Alina Diduța Brie
J. Clin. Med. 2025, 14(18), 6445; https://doi.org/10.3390/jcm14186445 - 12 Sep 2025
Viewed by 326
Abstract
Dyslipidemia is a major modifiable risk factor in patients with acute coronary syndrome (ACS), and effective management is essential to reduce the risk of recurrent cardiovascular events. Recent guidelines emphasize early, intensive lipid-lowering therapy (LLT) and increasingly recommend combination regimens to achieve ambitious [...] Read more.
Dyslipidemia is a major modifiable risk factor in patients with acute coronary syndrome (ACS), and effective management is essential to reduce the risk of recurrent cardiovascular events. Recent guidelines emphasize early, intensive lipid-lowering therapy (LLT) and increasingly recommend combination regimens to achieve ambitious low-density lipoprotein cholesterol (LDL-C) targets. This review evaluates current evidence and recommendations for dyslipidemia treatment in ACS, with a focus on the rationale, timing, and selection of combination therapy. We conducted a comprehensive review of recent clinical guidelines, randomized controlled trials, and observational studies addressing lipid management in ACS. The analysis included data on LDL-C targets, efficacy and safety of high-intensity statins, adjunctive non-statin therapies (ezetimibe, PCSK9 inhibitors), and the impact of dietary interventions. Early and intensive LLT, initiated within 24–48 h of ACS, is associated with significant reductions in recurrent events and mortality. High-intensity statins (atorvastatin 40–80 mg or rosuvastatin 20–40 mg) are first-line, with combination therapy (statin plus ezetimibe and/or PCSK9 inhibitor) recommended for patients not achieving LDL-C < 1.4 mmol/L (<55 mg/dL) or >50% reduction from baseline. Evidence supports further LDL-C lowering (<1.0 mmol/L) in very high-risk patients. The Mediterranean and DASH diets provide additional benefit in lipid profile optimization and risk reduction. Statins also confer pleiotropic effects, including anti-inflammatory and plaque-stabilizing actions. Recent studies and real-world data confirm the efficacy and safety of combination approaches but highlight the need for individualized therapy based on residual risk, comorbidities, and tolerability. Achieving guideline-recommended LDL-C targets in ACS patients often requires early initiation of combination lipid-lowering therapy. Optimal management should be individualized considering both LDL-C levels and broader risk profiles. Ongoing research is needed to refine patient selection for combination therapy and to integrate novel agents into clinical practice. Full article
(This article belongs to the Special Issue New Perspectives in Acute Coronary Syndrome)
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