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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sepsis: Current Updates and Perspectives

edited by

Ecaterina Scarlatescu

submission deadline 10 Aug 2026 | 12 articles | Viewed by 38406 | Submission Open

Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies

(This special issue belongs to the Section Intensive Care)

The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition

edited by

Winfried Schlee

and

Jorge Piano Simões

submission deadline 10 Aug 2026 | 5 articles | Viewed by 14624 | Submission Open

Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in Pediatric Critical Care Medicine

edited by

Lama Elbahlawan

submission deadline 10 Aug 2026 | 5 articles | Viewed by 4756 | Submission Open

Keywords: acute renal failure; acute respiratory failure; pediatric oncology; pediatric ICU; pediatric critical care medicine; multi-organ dysfunction

(This special issue belongs to the Section Clinical Pediatrics)

Advancements and Future Directions in Clinical Psychosis

edited by

Marco Colizzi

and

Alessandra Martinelli

submission deadline 10 Aug 2026 | 3 articles | Viewed by 4292 | Submission Open

Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innova-tive diagnostic tools

(This special issue belongs to the Section Mental Health)

Sports Cardiology: Current Clinical Status and Outlook into the Future

edited by Aakash Bavishi and Matthew W Martinez

submission deadline 10 Aug 2026 | 1 articles | Viewed by 1330 | Submission Open

Keywords: sports cardiology; athletes; cardiac imaging; hypertrophic cardiomyopathy; screening; electrocardiogram; electrophysiology; echocardiography; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Current Challenges and Perspectives in Aortic Valve Replacement

edited by

Leonardo Guimaraes

, Quentin Fischer and David Del Val

submission deadline 10 Aug 2026 | 1 articles | Viewed by 1297 | Submission Open

Keywords: aortic valve replacement; transcatheter aortic valve implantation (TAVI); surgical aortic valve replacement; prosthesis–patient mismatch; structural heart disease; heart team; valve durability; coronary access; valve-in-valve

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Cardiothoracic Anesthesiology

edited by

Marc Vives

submission deadline 10 Aug 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: cardiac anesthesiology; thoracic anesthesiology; precision medicine; prevention of organ dysfunction; mechanical circulatory support; minimally invasive surgery

(This special issue belongs to the Section Anesthesiology)

Advances in Musculoskeletal Rehabilitation and Functional Movement

edited by

Sanghee Park

submission deadline 13 Aug 2026 | 5 articles | Viewed by 4707 | Submission Open

Keywords: corrective exercise; functional training; biomechanics; resistance training; movement impairment; electromyography; muscle activation; musculoskeletal rehabilitation

(This special issue belongs to the Section Clinical Rehabilitation)

Cutaneous Head and Neck Melanoma: Advances in Diagnosis and Management

edited by Shirin Bajaj and Ata Moshiri

submission deadline 13 Aug 2026 | Viewed by 253 | Submission Open

Keywords: head and neck melanoma; lentigo maligna; Mohs micrographic surgery; reflectance confocal microscopy (RCM); line-field OCT (LC-OCT); ex vivo confocal microscopy; margin delineation; facial reconstruction; neoadjuvant immunotherapy; PRAME

(This special issue belongs to the Section Dermatology)

New Insights in Neonatal Intensive Care

edited by

Benjamim Ficial

Leonardo Gottin

and Martina Ciarcià

submission deadline 14 Aug 2026 | 5 articles | Viewed by 5701 | Submission Open

Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine

(This special issue belongs to the Section Clinical Pediatrics)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 15 Aug 2026 | 5 articles | Viewed by 11672 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section Infectious Diseases)

Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations

edited by Giuseppe Barilaro

submission deadline 15 Aug 2026 | 6 articles | Viewed by 9539 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies

(This special issue belongs to the Section Immunology & Rheumatology)

New Insight into Pain and Chronic Pain Management

edited by

Eung Don Kim

submission deadline 15 Aug 2026 | 4 articles | Viewed by 8844 | Submission Open

Keywords: chronic pain; pain management; pharmacological treatment; non-pharmacological interventions; neuromodula-tion; multidisciplinary approaches; personalized medicine; quality of life

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Perspectives in Amyotrophic Lateral Sclerosis: Diagnosis, Management and Future Opportunities

edited by

Matthias Boentert

submission deadline 15 Aug 2026 | 1 articles | Viewed by 5742 | Submission Open

Keywords: amyotrophic lateral sclerosis; early diagnosis; neuroimaging; biomarkers; treatment

(This special issue belongs to the Section Clinical Neurology)

Hypertension and Cardiovascular Disease: Clinical Updates and Perspectives: 2nd Edition

edited by

Valeria Visco

and Nicola Virtuoso

submission deadline 15 Aug 2026 | 7 articles | Viewed by 4863 | Submission Open

Keywords: hypertension management; cardiovascular risk assessment; novel antihypertensive therapies; hypertension in pregnancy; hypertensive emergencies; cardiovascular disease prevention; pharmacological interventions for cardiovascular disease

(This special issue belongs to the Section Cardiovascular Medicine)

Hearing Disorders: Diagnosis, Management, and Future Opportunities: 4th Edition

edited by

George K. Psillas

submission deadline 15 Aug 2026 | 2 articles | Viewed by 3483 | Submission Open

Keywords: middle ear surgery; otosclerosis; sensorineural hearing loss; sudden hearing; cochlear implant

(This special issue belongs to the Section Otolaryngology)

Minimally Invasive Surgery for Gastrointestinal Disorder

edited by

Amosy Ephreim M'Koma

submission deadline 15 Aug 2026 | 3 articles | Viewed by 2924 | Submission Open

Keywords: minimally invasive surgery; gastrointestinal disorder; laparoscopy; robotic surgery; colorectal surgery; gastric surgery; endoscopic technique; oncological outcomes; surgical innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Redefining Hemodialysis: Beyond Diffusion to Precision Therapy

edited by

Stefano Stuard

and Sagar Nigwekar

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1957 | Submission Open

Keywords: digitalized medical governance; precision dialysis; convective clearance; advanced membranes; hemodynamic stability; artificial intelligence; digital biomarkers; personalized prescription; cardiovascular protection; patient-reported outcome measures; clinical trial emulation

(This special issue belongs to the Section Nephrology & Urology)

Advances in the Diagnosis, Treatment and Prognosis of Aortic Stenosis: 2nd Edition

edited by Rita Milewski

submission deadline 15 Aug 2026 | 2 articles | Viewed by 1231 | Submission Open

Keywords: aortic valve stenosis; aortic valve replacement; surgical aortic valve replacement; transfemoral aortic valve replacement; risk stratification for aortic stenosis

(This special issue belongs to the Section Cardiology)

Spine Surgery: Novel Challenges and Opportunities

edited by

Tae-Hwan Kim

submission deadline 15 Aug 2026 | 1 articles | Viewed by 548 | Submission Open

Keywords: spine surgery; surgical outcomes; postoperative care; complications; epidemiology; diagnostic imaging; biomaterials; biomechanics; machine learning; artificial intelligence; predictive modeling; minimally invasive techniques; population-based studies; clinical decision-making

(This special issue belongs to the Section Orthopedics)

New Advances and Clinical Outcomes of Cardiothoracic Surgery

edited by Hee-Jung Kim and

Seung-Hyun Lee

submission deadline 15 Aug 2026 | Viewed by 459 | Submission Open

Keywords: cardiac surgery; coronary artery bypass grafting; heart valve surgery; aortic intervention; materials; precision medicine; artificial intelligence

(This special issue belongs to the Section General Surgery)

Clinical Neuroscience Insights: Exploring the Advances in Brain Health

edited by

Simona Massimino

and Francesco Tomaiuolo

submission deadline 15 Aug 2026 | Viewed by 347 | Submission Open

Keywords: neurodegenerative diseases; cognitive impairment; neuromodulation therapy; brain health; cognitive and affective processes; neurorehabilitation

(This special issue belongs to the Section Clinical Neurology)

Neurovascular Canvas: From Basic Science to Clinical Breakthroughs

edited by

Ciro De Luca

, Nicola Giannini and

Alessandro Viganò

submission deadline 15 Aug 2026 | Viewed by 324 | Submission Open

Keywords: neurovascular unit (NVU); neurodegeneration; vascular biology; stroke; disease modeling

(This special issue belongs to the Section Clinical Neurology)

Patient Safety and Clinical Outcomes in Robotic-Assisted Microsurgery and Endoscopic Surgery

edited by Tetsuji Uemura

submission deadline 15 Aug 2026 | Viewed by 324 | Submission Open

Keywords: endoscopic surgery; reconstructive surgery; robotic-assisted microsurgery; advanced surgical technologies; patient safety

(This special issue belongs to the Section General Surgery)

From Imaging to Intervention: Modern Approaches in Spine Disorders Management

edited by

Maria Chiara Maccarone

submission deadline 15 Aug 2026 | Viewed by 247 | Submission Open

Keywords: adolescent idiopathic scoliosis (AIS); spinal fusion; Cobb angle; bracing; skeletal maturity; radiographic imaging; multidisciplinary management

(This special issue belongs to the Section Orthopedics)

Gene Correction and Regenerative Therapies for Inherited Retinal Diseases: Clinical Perspectives

edited by Sushma Kalmodia

submission deadline 15 Aug 2026 | Viewed by 236 | Submission Open

Keywords: gene therapy; AAV; IRD; retinal organoids; RPE

(This special issue belongs to the Section Ophthalmology)

Keratoconus: Current Status and Prospects

edited by

Uxía Regueiro

and Isabel Lema

submission deadline 18 Aug 2026 | 4 articles | Viewed by 16694 | Submission Open

Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances

(This special issue belongs to the Section Ophthalmology)

Unraveling Myopia: Current Science, Clinical Impact, and Future Horizons

edited by Neeraj K Singh and Pablo De Gracia

submission deadline 19 Aug 2026 | 5 articles | Viewed by 13749 | Submission Open

Keywords: accommodation; contact lenses; ophthalmic lenses; myopia progression; epidemiology; myopia control interventions; pharmaceutical treatments; environmental and behavioral risk factors; imaging innovations in myopia

(This special issue belongs to the Section Ophthalmology)

Innovative Approaches to the Challenges of Neurodegenerative Disease

edited by Brian T. Bicknell and

Ann Liebert

submission deadline 20 Aug 2026 | 8 articles | Viewed by 23751 | Submission Open

Keywords: neurodegenerative disease; Parkinson’s disease; Alzheimer’s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Clinical Neurology)

Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy

edited by

Daniel H. S. Silverman

submission deadline 20 Aug 2026 | 4 articles | Viewed by 14496 | Submission Open

Keywords: cognition; prodromal; Alzheimer’s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI

(This special issue belongs to the Section Clinical Neurology)

Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research

edited by

Philippe R. Koninckx

, Arnaud Wattiez and

Sun-Wei Guo

submission deadline 20 Aug 2026 | 8 articles | Viewed by 13316 | Submission Open

Keywords: endometriosis; guidelines; surgery; medical treatment; training; heuristics

(This special issue belongs to the Section Clinical Guidelines)

Novel Therapeutic Targets with Inflammatory Bowel Diseases

edited by Konstantinos H. Katsanos and

Fotios S. Fousekis

submission deadline 20 Aug 2026 | 2 articles | Viewed by 12229 | Submission Open

Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Immunotherapy of Cancer

edited by

Jessica Chacon

and

Shrikanth Gadad

submission deadline 20 Aug 2026 | 3 articles | Viewed by 10185 | Submission Open

Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events

(This special issue belongs to the Section Oncology)

Current Challenges and Innovations in Emergency Medicine: From Prehospital Care to Critical Decision-Making in the Emergency Department

edited by

Efstratios Karagiannidis

, Barbara P. Fyntanidou and

Aikaterini Apostolopoulou

submission deadline 20 Aug 2026 | 9 articles | Viewed by 10007 | Submission Open

Keywords: emergency medicine; prehospital care; triage strategies; acute care; point-of-care diagnostics; artificial intelligence; telemedicine; emergency department; patient flow; healthcare systems; burnout in emergency care

(This special issue belongs to the Section Emergency Medicine)

The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention

edited by

Justyna Wyszyńska

and

Piotr Matłosz

submission deadline 20 Aug 2026 | 6 articles | Viewed by 9994 | Submission Open

Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits

(This special issue belongs to the Section Clinical Rehabilitation)

Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition

edited by

Mariarita Tarallo

Enrico Fiori

and Marco Bononi

submission deadline 20 Aug 2026 | 5 articles | Viewed by 9743 | Submission Open

Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men

(This special issue belongs to the Section Endocrinology & Metabolism)

Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques

edited by Francesco Coppolino and

Vincenzo Pota

submission deadline 20 Aug 2026 | 4 articles | Viewed by 9393 | Submission Open

Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management

(This special issue belongs to the Section Anesthesiology)

Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances

edited by

Cristian George Ţieranu

and

Adrian Saftoiu

submission deadline 20 Aug 2026 | 3 articles | Viewed by 9099 | Submission Open

Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Progress of Spine Surgery

edited by

Edoardo Mazzucchi

and Gianluca Vadalà

submission deadline 20 Aug 2026 | 6 articles | Viewed by 8610 | Submission Open

Keywords: spine surgery; rehabilitation; robotic surgery; spinal endoscopy; spinal tumor; back pain; minimally invasive surgery; spinal fusion

(This special issue belongs to the Section Clinical Neurology)

New Perspectives in Acute Coronary Syndrome

edited by Makoto Natsumeda

submission deadline 20 Aug 2026 | 4 articles | Viewed by 8548 | Submission Open

Keywords: acute coronary syndrome; PCI; interventional cardiology; coronary imaging; antiplatelet therapy; stentless PCI strategy; CABG; revascularization

(This special issue belongs to the Section Cardiology)

Neurosurgery: Recent Advances and New Perspectives in Skull Base Approaches

edited by Sèbastien Froelich and Matteo De Simone

submission deadline 20 Aug 2026 | 3 articles | Viewed by 8518 | Submission Open

Keywords: skull base; neuroanatomy; tumors; augmented reality; ETOA; EEA; exoscopy; endoscopy; multi-portal approaches

(This special issue belongs to the Section Clinical Neurology)

Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders

edited by

Clara Martinez-Perez

submission deadline 20 Aug 2026 | 3 articles | Viewed by 8148 | Submission Open

Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Gastrointestinal Inflammation

edited by

Ivana Jukic

submission deadline 20 Aug 2026 | 3 articles | Viewed by 7945 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation

edited by

Emmanouil Liodakis

submission deadline 20 Aug 2026 | 7 articles | Viewed by 7869 | Submission Open

Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation

(This special issue belongs to the Section Orthopedics)

Epidemiology of Hyperglycemia in Pregnancy and Its Maternofetal Adverse Outcomes

edited by

Giuseppe Seghieri

submission deadline 20 Aug 2026 | 6 articles | Viewed by 7444 | Submission Open

Keywords: gestational diabetes; diabetes in pregnancy; risk factors; epidemiology; maternofetal adverse outcomes in pregnancies with hypergliycemia; temporal trends

(This special issue belongs to the Section Endocrinology & Metabolism)

Plastic and Reconstructive Surgery: Cutting-Edge Expert Perspective

edited by

Roberto Cuomo

and

Ishith Seth

submission deadline 20 Aug 2026 | 7 articles | Viewed by 7084 | Submission Open

Keywords: plastic and reconstructive surgery; new perspectives; regeneration; microsurgery; oncoplastic; post bariatric; breast implant

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Hypertension: Clinical Treatment and Management

edited by

José L. Flores-Guerrero

submission deadline 20 Aug 2026 | 5 articles | Viewed by 6873 | Submission Open

Keywords: hypertension management; weight control; blood pressure monitoring; wearable technology; telemonitoring sys-tems; immune therapy; resistant hypertension; lifestyle interventions; cardiovascular health; advanced treatment strate-gies

(This special issue belongs to the Section Epidemiology & Public Health)

Advanced Hysteroscopic Technology for Gynecological Disease

edited by

Guglielmo Stabile

Luigi Nappi

and

Felice Sorrentino

submission deadline 20 Aug 2026 | 5 articles | Viewed by 6864 | Submission Open

Keywords: hysteroscopy; new technology; therapy; mini-invasive approach; laser; diagnosis; outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Hepatobiliary Surgery: State of the Art and Future Perspectives

edited by

Teresa Perra

and

Alberto Porcu

submission deadline 20 Aug 2026 | 2 articles | Viewed by 6858 | Submission Open

Keywords: hepatobiliary surgery; cholangiocarcinoma; hepatocellular carcinoma; liver metastases; benign liver lesions

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes

edited by Filippo Carannante and Leandro Siragusa

submission deadline 20 Aug 2026 | 4 articles | Viewed by 6696 | Submission Open

Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology

(This special issue belongs to the Section General Surgery)

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