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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Targets with Inflammatory Bowel Diseases

edited by Konstantinos H. Katsanos and

Fotios S. Fousekis

submission deadline 20 Feb 2026 | 2 articles | Viewed by 7305 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Non-Invasive Respiratory Support: Current Insights and Future Directions

edited by Giovanni Misseri and

Cesare Gregoretti

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7208 | Submission Open

Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Immunotherapy of Cancer

edited by

Jessica Chacon

and

Shrikanth Gadad

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6912 | Submission Open

Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events

(This special issue belongs to the Section Oncology)

Gastrointestinal Diseases: Clinical Challenges and Management

edited by Anusha Shirwaikar Thomas and

Yinghong Wang

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6861 | Submission Open

Keywords: GI bleed; nutrition; obstructive jaundice; drug-induced liver injury; GI motility; clostridium difficile infection; large bowel obstruction; colon cancer prevention and surveillance

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention

edited by

Justyna Wyszyńska

and

Piotr Matłosz

submission deadline 20 Feb 2026 | 5 articles | Viewed by 6549 | Submission Open

Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits

(This special issue belongs to the Section Clinical Rehabilitation)

Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management

edited by

Adrian Boicean

and

Cristian Ichim

submission deadline 20 Feb 2026 | 4 articles | Viewed by 6426 | Submission Open

Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiopulmonary Resuscitation in Emergency Care Units

edited by

Stavros Dimopoulos

and

Christos Kourek

submission deadline 20 Feb 2026 | 4 articles | Viewed by 6339 | Submission Open

Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes

(This special issue belongs to the Section Emergency Medicine)

Updates on Lumbar Spine Surgery for Degenerative Diseases

edited by

Se-Jun Park

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5952 | Submission Open

Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Gastrointestinal Inflammation

edited by

Ivana Jukic

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5426 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Intraocular Lenses for Cataract Surgery: Clinical Advances and Perspectives

edited by Choul Yong Park

submission deadline 20 Feb 2026 | 5 articles | Viewed by 5140 | Submission Open

Keywords: cataract surgery; intraocular lens; IOL formula; optic; complication; presbyopia; refractive

(This special issue belongs to the Section Ophthalmology)

Surgical Precision: The Impact of AI and Robotics in General Surgery

edited by Tamara M. H. Gall

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5077 | Submission Open

Keywords: robotic surgery; artificial intelligence in surgery; surgical training; AR in surgery; 3D imaging; surgical navigation

(This special issue belongs to the Section General Surgery)

Clinical Trends in Cardiomyopathy

edited by Giulia Iannaccone

submission deadline 20 Feb 2026 | 1 articles | Viewed by 5033 | Submission Open

Keywords: cardiomyopathy; genetics; treatment; targeted therapy; prognosis; long-term follow up

(This special issue belongs to the Section Cardiology)

Interstitial Lung Disease: From Diagnosis to Treatment

edited by

Takeshi Saraya

and Tomohisa Baba

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4959 | Submission Open

Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds

(This special issue belongs to the Section Respiratory Medicine)

Neurosurgery: Recent Advances and New Perspectives in Skull Base Approaches

edited by Sèbastien Froelich and Matteo De Simone

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4937 | Submission Open

Keywords: skull base; neuroanatomy; tumors; augmented reality; ETOA; EEA; exoscopy; endoscopy; multi-portal approaches

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Trauma and Emergency Medicine

edited by Yong-Soo Cho and Hyun Ho Ryu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4911 | Submission Open

Keywords: emergency medicine; epidemiology; cardiovascular disease

(This special issue belongs to the Section Emergency Medicine)

Pain Management: Current Challenges and Future Prospects

edited by Gian Marco Petroni

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4877 | Submission Open

Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs

(This special issue belongs to the Section Anesthesiology)

Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques

edited by Francesco Coppolino and

Vincenzo Pota

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4337 | Submission Open

Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management

(This special issue belongs to the Section Anesthesiology)

New Perspectives in Acute Coronary Syndrome

edited by Makoto Natsumeda

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4190 | Submission Open

Keywords: acute coronary syndrome; PCI; interventional cardiology; coronary imaging; antiplatelet therapy; stentless PCI strategy; CABG; revascularization

(This special issue belongs to the Section Cardiology)

Clinical Progress of Spine Surgery

edited by

Edoardo Mazzucchi

and Gianluca Vadalà

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4126 | Submission Open

Keywords: spine surgery; rehabilitation; robotic surgery; spinal endoscopy; spinal tumor; back pain; minimally invasive surgery; spinal fusion

(This special issue belongs to the Section Clinical Neurology)

Recent Developments in Hearing and Balance Disorders: 2nd Edition

edited by

Juan Carlos Amor-Dorado

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4120 | Submission Open

Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance

(This special issue belongs to the Section Otolaryngology)

Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia

edited by

Blanca Gonzalez-Sanchez

María Jiménez-Palomares

and

Juan Rodríguez-Mansilla

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4060 | Submission Open

Keywords: cognition; dementia; rehabilitation; exercise; memory; physical activity; Alzheimer’ s disease; non-pharmacological therapies

(This special issue belongs to the Section Clinical Rehabilitation)

New Insights in the Diagnosis, Treatment and Monitoring of Anemia, Inflammation and Infection

edited by

Christian Hönemann

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3889 | Submission Open

Keywords: anemia; inflammation; infection; diagnostic tools; therapeutic strategies

(This special issue belongs to the Section Hematology)

Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes

edited by Filippo Carannante and Leandro Siragusa

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3847 | Submission Open

Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology

(This special issue belongs to the Section General Surgery)

Acute Kidney Events in Intensive Care Patients

edited by Kada Klouche

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3784 | Submission Open

Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers

(This special issue belongs to the Section Intensive Care)

Management of Pregnancy Complications: 2nd Edition

edited by Ariel Many

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3622 | Submission Open

Keywords: high-risk pregnancy; preterm labor; fetal growth restriction; gestational diabetes; twins; hypertensive disorders during pregnancy; preeclampsia; IUGR; prenatal genetics; congenital anomaly detection; cesarean section; complications of labor and delivery

(This special issue belongs to the Section Obstetrics & Gynecology)

Kidney Transplantation: State of the Art Knowledge

edited by

Georgios Koimtzis

, Georgios Geropoulos and Kyriakos Psarras

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3491 | Submission Open

Keywords: kidney transplantation; end-stage renal disease; immunosuppression; organ donation; graft survival; graft rejection

(This special issue belongs to the Section Nephrology & Urology)

Advances in Knee Surgery and Musculoskeletal Rehabilitation: 2nd Edition

edited by

Giulio Maria Marcheggiani Muccioli

and

Giada Lullini

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3463 | Submission Open

Keywords: computer-assisted surgical navigation; smart cutting guides; robotic-assisted surgery; fast-track; telemedicine; tele-rehabilitation; virtual reality

(This special issue belongs to the Section Orthopedics)

Traumatic Brain Injury—Clinical Translational Approaches, Demographic Change, and Neuro-Critical Care

edited by

Peter Radermacher

and Thomas Kapapa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3371 | Submission Open

Keywords: intracranial hypertension; cerebral perfusion pressure; decompressive craniectomy; brain tissue oxygenation; brain tissue microdialysis; blood brain barrier; neuro-critical care

(This special issue belongs to the Section Brain Injury)

State of the Art in Invasive Vascular Interventions (Second Edition)

edited by

Edit Dósa

and Luca Mezzetto

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3325 | Submission Open

Keywords: coronary artery interventions; non-coronary artery cardiac interventions; open surgical cardiac procedures; endo-vascular interventions; open surgical vascular procedures

(This special issue belongs to the Section Vascular Medicine)

Advances in Diagnosis and Therapeutic Strategies for Uveal Melanoma

edited by Yong Qin

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3301 | Submission Open

Keywords: uveal melanoma; immunotherapy; targeted therapy; biomarker; disease management; drug development; drug resistance

(This special issue belongs to the Section Ophthalmology)

Epidemiology of Hyperglycemia in Pregnancy and Its Maternofetal Adverse Outcomes

edited by

Giuseppe Seghieri

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3121 | Submission Open

Keywords: gestational diabetes; diabetes in pregnancy; risk factors; epidemiology; maternofetal adverse outcomes in pregnancies with hypergliycemia; temporal trends

(This special issue belongs to the Section Endocrinology & Metabolism)

Global Expert Views on Clinical Aesthetic Plastic Surgery

edited by

Won Lee

and

Seong Hwan Kim

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2900 | Submission Open

Keywords: aesthetic surgery; cosmetic surgery; dermal fillers; facial plastic surgery; soft tissue fillers; filler complications; ultrasound guided filler injection; hyaluronic acid filler

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice

edited by Ilaria Marcantoni and Michela Casella

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2787 | Submission Open

Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing

(This special issue belongs to the Section Cardiology)

Current Advances and Future Perspectives of Ischemic Stroke

edited by

Marzia Baldereschi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2671 | Submission Open

Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood– brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke

(This special issue belongs to the Section Clinical Neurology)

Advanced Hysteroscopic Technology for Gynecological Disease

edited by

Guglielmo Stabile

Luigi Nappi

and

Felice Sorrentino

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2611 | Submission Open

Keywords: hysteroscopy; new technology; therapy; mini-invasive approach; laser; diagnosis; outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Pancreatitis: Current Perspectives on Diagnosis and Management

edited by

Alberto Maringhini

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2601 | Submission Open

Keywords: acute pancreatitis; chronic pancreatitis; pancreatitis; pancreatic cancer; eco-endoscopy; gallstones; biliary stones

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thrombosis: Latest Advances and Prospects

edited by Manila Gaddh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2591 | Submission Open

Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation

(This special issue belongs to the Section Hematology)

Management of Endometriosis: Evidence-Based Updated by Collective Clinical Experience and New Perspectives from Research

edited by

Philippe R. Koninckx

, Arnaud Wattiez and

Sun-Wei Guo

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2523 | Submission Open

Keywords: endometriosis; guidelines; surgery; medical treatment; training; heuristics

(This special issue belongs to the Section Clinical Guidelines)

Advances in Neurological Rehabilitation: Innovations and Clinical Insights

edited by

Anna Berardi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2518 | Submission Open

Keywords: rehabilitation; neurology; assessment; occupational therapy; disability; inclusion

(This special issue belongs to the Section Clinical Neurology)

Current Trends and Future Challenges in Percutaneous Coronary Intervention

edited by Deniz Mutlu

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2434 | Submission Open

Keywords: PCI; IVUS; OCT; FFR; physiology; CT-guided PCI; complex PCI; CTO; bifurcation; coronary complications; mechanical circulatory support

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates in Stem Cell Transplants

edited by Daniele Avenoso and Michele Malagola

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2407 | Submission Open

Keywords: AML; CML; lymphoma; allo-HSCT; GVHD; MDS; AA

(This special issue belongs to the Section Hematology)

Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation

edited by Adriano Pellicelli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2111 | Submission Open

Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Translation of Technological Innovations in Diabetes Therapeutics

edited by

Nowreen Haq

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2045 | Submission Open

Keywords: diabetes management; remote patient monitoring (RPM); artificial intelligence (AI); machine learning (ML); wearable sensors; point-of-care diagnostics; centrifugal microfluidics; glucose monitoring

(This special issue belongs to the Section Endocrinology & Metabolism)

Integrating Psychological Science into Chronic Pain Management: Emerging Approaches and Insights

edited by Scott G. Ravyts and Margot De Kooning

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2017 | Submission Open

Keywords: chronic primary pain; nociplastic pain; coping strategies; depression; anxiety; trauma

(This special issue belongs to the Section Mental Health)

Clinical Insights and Emerging Strategies in Chronic Pain Management

edited by

Cheol Lee

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1733 | Submission Open

Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care

(This special issue belongs to the Section Anesthesiology)

Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders

edited by

Clara Martinez-Perez

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1655 | Submission Open

Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science

(This special issue belongs to the Section Ophthalmology)

Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies

edited by

Nicola Maurea

and

Alfredo Mauriello

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1641 | Submission Open

Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT

(This special issue belongs to the Section Cardiology)

Rising Star: Advanced Physical Therapy and Expansion

edited by

Hyolyun Roh

submission deadline 20 Feb 2026 | 3 articles | Viewed by 1628 | Submission Open

Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach

(This special issue belongs to the Section Clinical Rehabilitation)

Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain

edited by

Maciej Rachwał

and

Joanna Baran

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1617 | Submission Open

Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain

(This special issue belongs to the Section Orthopedics)

Breast Cancer: Symptoms, Types, Causes & Treatment

edited by Min-Jeong Cho and Sara Myers

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1613 | Submission Open

Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies

(This special issue belongs to the Section Obstetrics & Gynecology)

Displaying special issue 301-350 on page 7 of 31.

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