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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Foot and Ankle Surgery: State of the Art and Future Perspectives

edited by Sung Jae Kim and Jaehwang Song

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8825 | Submission Open

Keywords: foot and ankle surgery; hallux disorders; lesser toe problem; diabetic foot salvage; calcaneal fracture; pilon fracture; ligament disorder

(This special issue belongs to the Section Orthopedics)

Traumatic Brain Injury: Current Treatment and Future Options

edited by

Ismail Zaed

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8791 | Submission Open

Keywords: traumatic brain injury; trauma; biomarkers; post-traumatic outcome; epidemiology

(This special issue belongs to the Section Clinical Neurology)

Attention-Deficit/Hyperactivity Disorder (ADHD): Advances in Diagnosis and Treatment

edited by Yanli Zhang-James

submission deadline 20 Jan 2026 | 3 articles | Viewed by 8678 | Submission Open

Keywords: attention-deficit/hyperactivity disorder; neurodevelopmental disorder; hyperactivity; children; adolescents; adult

(This special issue belongs to the Section Clinical Neurology)

Innovative Clinical Approaches in Oral Health Prevention and Management

edited by

Giulia Orilisi

Rossana Izzetti

and Flavia Vitiello

submission deadline 20 Jan 2026 | 6 articles | Viewed by 7313 | Submission Open

Keywords: oral health; oral prevention; teeth remineralization; oral pathology; oral health management; preventive dentistry; translational dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Plastic Surgery: Challenges and Future Directions

edited by Philip Brazio and Edward C. Ray

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7178 | Submission Open

Keywords: plastic surgery; reconstructive surgery; esthetic surgery; innovation; challenges; technology

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition

edited by

Kana Fujikura

and Panagiota Christia

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6720 | Submission Open

Keywords: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease

(This special issue belongs to the Section Cardiology)

Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques

edited by

Raffaele Natella

, Aniello Iovino and Vito Stifano

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6076 | Submission Open

Keywords: MRI; MSK imaging; soft-tissue tumors; DTI; neuropathies; inflammatory neuropathies; nerve entrapment; motor neuron disease; neurophysiology; MSK ultrasound; peripheral nerve tumor; nerve entrapment; nerve reconstruction

(This special issue belongs to the Section Clinical Neurology)

Hip Fracture and Surgery: Clinical Updates and Challenges

edited by

Norio Imai

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5956 | Submission Open

Keywords: antiosteoporosis medication; fracture liaison service; osteosynthesis; total hip arthroplasty; hemiarthroplasty

(This special issue belongs to the Section Orthopedics)

Advancing Psycho-Oncology: Multidimensional Approaches and Challenges to Cancer Care

edited by

Benedetta Muzii

Nelson Mauro Maldonato

and

Andrea Bovero

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5778 | Submission Open

Keywords: psycho-oncology; cancer care; adaptation process; illness experience; risk and protective factors; mental health care; oncofertility; palliative care; critical experience; prevention; qualitative and quantitative methods; quality of life; health behaviors

(This special issue belongs to the Section Mental Health)

Clinical Challenges of Pelvic Floor Disorders Management

edited by

Matteo Frigerio

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5293 | Submission Open

Keywords: pelvic floor disorders; pelvic organ prolapse; urinary incontinence; surgery; diagnostics; pelvic pain; vulvodynia; urinary tract symptoms; mesh-related complications

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Diagnosis, Risk Stratification, and Personalized Management in Acute Coronary Syndromes

edited by

Efstratios Karagiannidis

, Barbara P. Fyntanidou and Aikaterini Apostolopoulou

submission deadline 20 Jan 2026 | 5 articles | Viewed by 5117 | Submission Open

Keywords: acute coronary syndrome (ACS); cardiovascular disease (CVD); ischemic heart disease; emergency medicine; risk stratification; personalized treatment; antiplatelets; primary and secondary prevention

(This special issue belongs to the Section Cardiology)

New Advances in Cardiovascular Diseases: The Cutting Edge

edited by

Fabiana Lucà

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5076 | Submission Open

Keywords: cardiovascular disease (CVD); preventive cardiology; cardiac pharmacology; coronary artery disease (CAD); heart failure (HF); atrial fibrillation (AF); supraventricular and ventricular arrhythmias

(This special issue belongs to the Section Cardiovascular Medicine)

Eating Disorders: Current Epidemiology and Advances in Diagnosis and Treatment—Second Edition

edited by

Arthur Eumann Mesas

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4477 | Submission Open

Keywords: eating disorder; bulimia nervosa; anorexia nervosa; binge eating disorder; sociocultural context; epidemiology; di-agnosis; treatment; prevention

(This special issue belongs to the Section Mental Health)

Microsurgery: Current and Future Challenges

edited by

Matthias Aitzetmüller-Klietz

submission deadline 20 Jan 2026 | 5 articles | Viewed by 4336 | Submission Open

Keywords: microsurgery; reconstruction; reconstructive surgery; breast reconstruction; extremity reconstruction

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Insights into Pediatric Critical Care

edited by Katherine Biagas and Daniel E Sloniewsky

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3945 | Submission Open

Keywords: PICU; anemia; blood transfusion; critically ill children; traumatic hemorrhage

(This special issue belongs to the Section Intensive Care)

Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome

edited by

Razvan Ionut Ghinea

Ioana-Sofia Pop-Ciutrilă

and

Luminita-Maria Nica

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3927 | Submission Open

Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Sustaining Success Through Innovation in Kidney Transplantation

edited by Junji Uchida

submission deadline 20 Jan 2026 | 4 articles | Viewed by 3882 | Submission Open

Keywords: kidney transplantation; long-term graft survival; immunosuppression; organ shortage; post-transplant complication

(This special issue belongs to the Section Nephrology & Urology)

Artificial Intelligence (AI) and Deep Learning (DL) in Medical Imaging

edited by

Francesco Pucciarelli

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3790 | Submission Open

Keywords: artificial intelligence; deep learning; imaging; diagnosis; precision medicine; oncologic

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Long COVID and Cardiovascular Health: Clinical Perspectives on Risk and Management

edited by Mariana Tudoran and

Cristina Tudoran

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3660 | Submission Open

Keywords: long COVID; cardiovascular disease; long COVID therapy; management of long COVID; mechanisms of long COVID

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Management of Cardiogenic Shock and Cardiac Arrest: 2nd Edition

edited by Jaime A. Hernández-Montfort

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3600 | Submission Open

Keywords: cardiogenic shock; cardiac arrest; temporary mechanical circulatory support; ECMO; transitions; heart recovery; heart replacement

(This special issue belongs to the Section Cardiology)

Clinical Advances in Autoimmune Disorders

edited by

Chiara Pellicano

and

Edoardo Rosato

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3463 | Submission Open

Keywords: systemic sclerosis; Raynaud’ s phenomenon; digital ulcers; scleroderma renal crisis; pulmonary arterial hypertension; interstitial lung disease; fibrosis

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Application of Radiotherapy in Modern Oncology

edited by

Lukas Käsmann

and

Fabian Weykamp

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3269 | Submission Open

Keywords: brain metastasis; bone metastasis; brain tumors; head and neck cancers; thoracic oncology; breast cancer; prostate cancer; sarcoma

(This special issue belongs to the Section Oncology)

Allergen-Specific Immunotherapy (AIT) for Allergic Diseases of the Respiratory Tract and Food Allergies

edited by

Ralph Mösges

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3268 | Submission Open

Keywords: allergy; allergic rhinitis; allergic conjunctivitis; allergic asthma; food allergy; peptide immunotherapy; allergoids; SLIT; SCIT; OIT

(This special issue belongs to the Section Immunology & Rheumatology)

Sports Injuries: Recent Advances in Prevention and Rehabilitation, 2nd Edition

edited by

Stasinopoulos Dimitrios

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3266 | Submission Open

Keywords: sports injuries; treatment; musculoskeletal disorders; rehabilitation; physical rehabilitation; exercise science; sports science; injury prevention

(This special issue belongs to the Section Sports Medicine)

Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition

edited by Gerond V. Lake-Bakaar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3139 | Submission Open

Keywords: NAFLD; NASH; cirrhosis; hepatocellular carcinoma; hepatitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current and Emerging Therapies for Rheumatoid Arthritis

edited by

Yoshiro Horai

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3121 | Submission Open

Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)

(This special issue belongs to the Section Immunology & Rheumatology)

Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke

edited by

Fusao Ikawa

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3072 | Submission Open

Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke

(This special issue belongs to the Section Clinical Neurology)

Advances and Trends in Pediatric Surgery

edited by

Nikolaos Zavras

and

Anastasia Dimopoulou

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2865 | Submission Open

Keywords: pediatric surgery; minimally invasive surgery; robotics; trends; advances

(This special issue belongs to the Section Clinical Pediatrics)

Advances in the Treatment of Glaucoma and Ocular Hypertension

edited by Ahnul Ha

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2383 | Submission Open

Keywords: glaucoma; ocular hypertension; intraocular pressure (IOP); minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI); neuroprotection; meta-analysis

(This special issue belongs to the Section Ophthalmology)

Sarcopenia Across the Lifespan: Risk Factors, Mechanisms, and Management in Aging and Disease

edited by

Juan Mielgo-Ayuso

and

Natalia Busto

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2380 | Submission Open

Keywords: sarcopenia; aging; chronic disease; risk factors; muscle physiology; prevention; nutrition; exercise; treatment strategies

(This special issue belongs to the Section Orthopedics)

Advances in Tuberculosis: Comprehensive Insights and Management Strategies

edited by Aliaksandr Skrahin

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2357 | Submission Open

Keywords: pulmonary and extra-pulmonary tuberculosis (TB); TB epidemiology; TB screening; TB prevention; TB diagnostics; TB treatment; TB co-infections (e.g.; HIV; Hepatitis B and C); TB co-morbidities (e.g.; diabetes); host and Mycobacteria genetic; molecular mechanisms and genotype/phenotype correlations

(This special issue belongs to the Section Infectious Diseases)

Emerging Treatment Options in Inflammatory Bowel Disease

edited by

Sandro Ardizzone

and Roberta Maselli

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2339 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; small molecule therapies; personalized medicine; therapeutic drug monitoring; immunology; gut microbiome; clinical practice; endoscopic mucosal resection (EMR); endoscopic submucosal dissection (ESD); endoscopic balloon dilation and endoscopic stent placement; chromoendoscopy; confocal laser endomicroscopy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advanced Diagnostic and Therapeutic Strategies for Sarcoidosis

edited by

Małgorzata Sobiecka

and

Monika Szturmowicz

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2290 | Submission Open

Keywords: sarcoidosis; cardiac sarcoidosis; pulmonary fibrosis; magnetic resonance imaging; FDG-PET/CT; echocardiography; neurosarcoidosis; differential diagnosis; hypercalcaemia; IGRA; sarcoidosis-associated pulmonary hypertension; fatigue; corticosteroids; metotrexat; infliximab; antifibrotic treatment; lung transplantation; artificial intelligence; broncho-alveolar lavage; cytokines

(This special issue belongs to the Section Respiratory Medicine)

Endometriosis: Diagnosis and Treatment

edited by

Camran R. Nezhat

and

Ceana Nezhat

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1637 | Submission Open

Keywords: endometriosis; diagnosis; video laparoscopy with and without robotic assistance; chronic pelvic pain; fertility preservation; minimally invasive surgery; biomarkers; artificial intelligence in endometriosis; adenomyosis; and adenomyoma care; multidisciplinary care; personalized medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Glaucoma Surgery: Current Challenges and Future Perspectives

edited by

Tina Tzee Ling Wong

and

Esther M. Hoffmann

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1440 | Submission Open

Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics

(This special issue belongs to the Section Ophthalmology)

Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases

edited by Mario J. Garcia and

Fatih Yalcin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S

(This special issue belongs to the Section Cardiology)

Acute Myocardial Infarction: Diagnosis, Treatment, and Rehabilitation

edited by

Francesca Giordana

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1031 | Submission Open

Keywords: acute myocardial infarction; coronary angioplasty; acute heart failure; cardiogenic shock; rehabilitation programs

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiac Arrest Research: Neuroprognostication and Improving Outcomes

edited by

Jae Hoon Lee

and Jin-hong Min

submission deadline 20 Jan 2026 | 1 articles | Viewed by 988 | Submission Open

Keywords: cardiac arrest; prognosis; hypothermia; induced; resuscitation; magnetic resonance imaging; electroencephalography; blood pressure; hypoxia-ischemia; brain; extracorporeal membrane oxygenation

(This special issue belongs to the Section Cardiovascular Medicine)

Insights and Innovations in Sports Cardiology

edited by

Garyfallia K. Pepera

submission deadline 20 Jan 2026 | 2 articles | Viewed by 946 | Submission Open

Keywords: sports cardiology; athlete heart; cardiovascular screening; arrhythmias; sudden cardiac death; cardiac rehabilitation; exercise prescription; mobile health; preventive cardiology; personalized medicine; pediatric fitness

(This special issue belongs to the Section Sports Medicine)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jan 2026 | 1 articles | Viewed by 893 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

New Perspectives in Chronic Kidney Disease, Transplantation and Immune System

edited by

Maria Daoudaki

and Dimitrios A. Tsakiris

submission deadline 20 Jan 2026 | 1 articles | Viewed by 879 | Submission Open

Keywords: kidney transplantation; HLA; matching at the epitope level; DSAs; complement; kidney disease epigenetics; diabetic nephropathy; hemostasis; graft rejection; B and T cell immunophenotyping; end stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Idiopathic Pulmonary Fibrosis (IPF): Current Perspectives and Future Directions

edited by Vito D’Agnano

submission deadline 20 Jan 2026 | 1 articles | Viewed by 876 | Submission Open

Keywords: pulmonary fibrosis; IPF; ILD; antifibrotics; EMT; respiratory physiology; metabolism

(This special issue belongs to the Section Respiratory Medicine)

Current Practice and Future Perspectives on Laryngeal Surgery

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 792 | Submission Open

Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery

(This special issue belongs to the Section Otolaryngology)

Artificial Intelligence (AI) in Dental Clinical Practice

edited by

Eiji Tanaka

and Keiichiro Watanabe

submission deadline 20 Jan 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Rehabilitation and Treatment of Post-COVID-19 Condition

edited by

Indre Bileviciute-Ljungar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 731 | Submission Open

Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work

(This special issue belongs to the Section Clinical Rehabilitation)

Multiple Myeloma: Therapeutic and Management Strategies

edited by Terri Parker

submission deadline 20 Jan 2026 | 1 articles | Viewed by 718 | Submission Open

Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management

(This special issue belongs to the Section Hematology)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 666 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jan 2026 | 1 articles | Viewed by 628 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Prenatal Diagnosis and Fetal Therapy

edited by

Mar Bennasar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 541 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiopulmonary Resuscitation in the Emergency Care Unit

edited by

Martín Otero-Agra

, Felipe Fernández-Méndez,

Myriam Santos-Folgar

and

María Fernández-Méndez

submission deadline 20 Jan 2026 | 1 articles | Viewed by 441 | Submission Open

Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit

(This special issue belongs to the Section Emergency Medicine)

Displaying special issue 451-500 on page 10 of 31.