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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Study on Biofunctional Properties of Plant Bioactives

edited by

Isidora Milosavljevic

and

Jovana N. Novakovic

submission deadline 10 Oct 2026 | Viewed by 170 | Submission Open

Keywords: plant bioactives; bioactive compounds; phytochemicals; molecular mechanisms; oxidative stress; anti-inflammatory activity; therapeutic potential; structure– activity relationship; cell culture models; animal models

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Therapy of Heart Failure

edited by

Ruth Magaye

submission deadline 10 Oct 2026 | Viewed by 159 | Submission Open

Keywords: heart failure; organ-cross talk; metabolic derangements; molecular mechansims; sex differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multi-Omics Insights into Cardiovascular and Cerebrovascular Diseases

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 10 Oct 2026 | Viewed by 115 | Submission Open

Keywords: multi-omics integration; atherosclerosis; stroke; cerebral small vessel disease (cSVD); heart failure; coronary artery disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sustainable Bioactives from Plants: From Molecular Function to Fermentation

edited by Zofia Nizioł–Łukaszewska and

Martyna Zagórska-Dziok

submission deadline 10 Oct 2026 | Viewed by 108 | Submission Open

Keywords: agro-industrial by-products; plant-based waste materials; microbial fermentation; biotransformation; molecular characterization; phytochemical profiling; anti-aging activity; dermatological applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nucleic Acid Therapeutics: From Molecular Mechanisms to Delivery, Manufacturing, and Clinical Translation

edited by

Zongjie Wang

and

Jie Wang

submission deadline 15 Oct 2026 | Viewed by 90 | Submission Open

Keywords: nucleic acid delivery; nanoparticle delivery systems; intracellular trafficking; endosomal escape; cellular metabolism; immunogenicity; process development

(This special issue belongs to the Section Molecular Pharmacology)

RNA Modification Databases and Bioinformatic Tools for Epitranscriptome Research

edited by

Bowen Song

and Yue Wang

submission deadline 17 Oct 2026 | Viewed by 102 | Submission Open

Keywords: epitranscriptomics; RNA modification; bioinformatics; computational tools; biological databases; machine learning; high-throughput sequencing; direct RNA sequencing; multi-omics integration; post-transcriptional regulation

(This special issue belongs to the Section Molecular Informatics)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Oct 2026 | 7 articles | Viewed by 17342 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Precision Medicine: Unraveling Novel Mechanisms and Delivery Strategies in Complex Diseases

edited by

Nuno Vale

submission deadline 20 Oct 2026 | 5 articles | Viewed by 16745 | Submission Open

Keywords: molecular precision therapeutics; disease biomarkers; novel therapeutic molecules; drug delivery strategies; personalized medicine; bioinformatics; nanotechnology; synthetic biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Oct 2026 | 6 articles | Viewed by 15979 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Oct 2026 | 4 articles | Viewed by 14367 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Oct 2026 | 4 articles | Viewed by 12420 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition

edited by

Bijan Safai

submission deadline 20 Oct 2026 | 4 articles | Viewed by 10331 | Submission Open

Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Treatments for Gynecological Cancers

edited by

Nicoletta D'Alessandris

submission deadline 20 Oct 2026 | 2 articles | Viewed by 9965 | Submission Open

Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Oct 2026 | 4 articles | Viewed by 9534 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Oct 2026 | 5 articles | Viewed by 9069 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds of Natural Origin: 2nd Edition

edited by

Katarzyna Pacyga

submission deadline 20 Oct 2026 | 5 articles | Viewed by 8900 | Submission Open

Keywords: plants; extraction methods; bioactive compounds; natural products; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 20 Oct 2026 | 2 articles | Viewed by 8629 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition

edited by

Anna Duda-Madej

submission deadline 20 Oct 2026 | 2 articles | Viewed by 7471 | Submission Open

Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Recent Advances in Bioactive Compounds in Human Health

edited by

Dorota Gumul

submission deadline 20 Oct 2026 | 5 articles | Viewed by 7424 | Submission Open

Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Micropollutants in Various Enviroments

edited by

Anna Lenart-Boroń

submission deadline 20 Oct 2026 | 4 articles | Viewed by 7367 | Submission Open

Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Osteoarthritis Pathways and Biomarker Research

edited by

Előd Ernő Nagy

submission deadline 20 Oct 2026 | 6 articles | Viewed by 7342 | Submission Open

Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 20 Oct 2026 | 4 articles | Viewed by 6657 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 20 Oct 2026 | 6 articles | Viewed by 6257 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Adsorbing Materials

edited by Mounia Achak

submission deadline 20 Oct 2026 | 4 articles | Viewed by 6224 | Submission Open

Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications

(This special issue belongs to the Section Materials Science)

Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications

edited by

Bin Li

submission deadline 20 Oct 2026 | 5 articles | Viewed by 6176 | Submission Open

Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 20 Oct 2026 | 3 articles | Viewed by 5845 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Oct 2026 | 3 articles | Viewed by 5606 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Forest Tree Genetics, Breeding and Environmental Adaption

edited by

Jingli Yang

and

Huiyu Li

submission deadline 20 Oct 2026 | 2 articles | Viewed by 5348 | Submission Open

Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Oct 2026 | 5 articles | Viewed by 5329 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors

edited by

Walid Shalata

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4933 | Submission Open

Keywords: tyrosine kinase inhibitors; immunotherapy; monoclonal antibodies; CAR-T cells

(This special issue belongs to the Section Molecular Oncology)

Zebrafish Model for Neurological Research

edited by

Mattia Toni

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4824 | Submission Open

Keywords: zebrafish ; Danio rerio ; brain ; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 4633 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Parasitic Infection

edited by Marcin Wiśniewski and

Piotr Bąska

submission deadline 20 Oct 2026 | 4 articles | Viewed by 4462 | Submission Open

Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4452 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets

edited by Souleymane Abdoul-Azize

submission deadline 20 Oct 2026 | 3 articles | Viewed by 4363 | Submission Open

Keywords: small-molecule drugs; signal transduction; therapeutic targets; therapeutic resistance; oncogenic signaling; novel biomarkers; cancer therapy; cancer signaling pathways; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Metabolic Regulators of Bone Health

edited by

Akkouch Adil

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4357 | Submission Open

Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—2nd Edition

edited by

Elisa Oltra

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4259 | Submission Open

Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 20 Oct 2026 | 5 articles | Viewed by 4232 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 Oct 2026 | 1 articles | Viewed by 4025 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Biomechanics and Molecular Research on Glioblastoma: 2nd Edition

edited by

Lorenzo Corsi

submission deadline 20 Oct 2026 | 3 articles | Viewed by 3234 | Submission Open

Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3156 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Oct 2026 | 4 articles | Viewed by 3087 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Immunity in Neurodegenerative Diseases: Systemic Immune Imbalance, Neuroinflammation, and Beyond—2nd Edition

edited by

Ivana Munitic

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2781 | Submission Open

Keywords: neurodegeneration; CNS immunosurveillance; neuroinflammation; neuroimmune axis; glia; T cells; phagocytosis; immunomodulation; autoimmunity; immunodeficiency

(This special issue belongs to the Section Molecular Neurobiology)

Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2740 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Orofacial Pain and Headache

edited by

Adriana Elena Bulboaca

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2701 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress in Plants, 2nd Edition

edited by

Xiujun Zhang

submission deadline 20 Oct 2026 | 4 articles | Viewed by 2558 | Submission Open

Keywords: abiotic stress; ROS; redox; antioxidants; phytohormones; ethylene; plant stress eco-physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Brain Plasticity

edited by

Beatrice Uguagliati

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2217 | Submission Open

Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond

edited by

Jian Zhang

and

Michael Deyholos

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1822 | Submission Open

Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Next-Generation Sequencing for Aging and Cancer Research

edited by Hyunsoo Kim

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1766 | Submission Open

Keywords: next-generation sequencing; aging; cancer genomics; cellular senescence; single-cell sequencing; epigenomics; transcriptomics; tumor evolution; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Advances in Plant Molecular Breeding and Molecular Diagnostics

edited by

Jiří Sedlák

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1598 | Submission Open

Keywords: plant molecular breeding; molecular diagnostics; pathogen detection; disease symptomatology; genetic resources; genetic diversity; phenology; genotype– phenotype integration; genome editing; omics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 2051-2100 on page 42 of 65.

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