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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis and Molecular Therapy of Brain Tumor
edited by
submission deadline 15 Dec 2025 | Viewed by 58 | Submission Open
Keywords: brain tumor; glioma; glioblastoma; astrocytoma; oligodendroglioma; epigenetics; precision medicine
(This special issue belongs to the Section Molecular Oncology)
High-Density Lipoproteins in Health and Disease
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 20872 | Submission Open
Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy
(This special issue belongs to the Section Molecular Biology)
Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies
edited by Blerida Banushi
submission deadline 20 Dec 2025 | 7 articles | Viewed by 20839 | Submission Open
Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Retinal Diseases: 2nd Edition
edited by Minzhong Yu
submission deadline 20 Dec 2025 | 8 articles | Viewed by 20572 | Submission Open
Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomimetic Materials Applied in the Analytical and Biomedical Fields submission deadline 20 Dec 2025 | 6 articles | Viewed by 16944 | Submission Open
Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors
(This special issue belongs to the Section Materials Science)
Bacteriophages Biology and Bacteriophage-Derived Technologies
edited by Wilfried Moreira
submission deadline 20 Dec 2025 | 5 articles | Viewed by 16642 | Submission Open
Keywords: bacteriophage; antibiotic resistance; biofilm; molecular biology; genetic engineering; synthetic biology
(This special issue belongs to the Section Biochemistry)
Plant Responses to Biotic and Abiotic Stresses
edited by
submission deadline 20 Dec 2025 | 18 articles | Viewed by 16171 | Submission Open
Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms
edited by
submission deadline 20 Dec 2025 | 13 articles | Viewed by 14682 | Submission Open
Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Exosomes and Extracellular Vesicles in Health and Diseases: 3rd Edition submission deadline 20 Dec 2025 | 7 articles | Viewed by 13015 | Submission Open
Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Computational Approaches in Drug Design: Novel Methodologies and Applications
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 12812 | Submission Open
Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence
(This special issue belongs to the Section Molecular Informatics)
Plant Genome Editing
edited by Lei Gao
submission deadline 20 Dec 2025 | 5 articles | Viewed by 12280 | Submission Open
Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights of Fungal and Plant Lipids: Structural Diversity, Metabolism and Applications
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 12239 | Submission Open
Keywords: lipidomics; fatty acids; glycerolipids; sphingolipids; sterols; oxylipins; fungal and plant lipid metabolism
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Bioactives and Inflammation, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 12133 | Submission Open
Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging
(This special issue belongs to the Section Bioactives and Nutraceuticals)
(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems
edited by , Milton Saier and Gabriel Moreno-Hagelsieb
submission deadline 20 Dec 2025 | 3 articles | Viewed by 11660 | Submission Open
Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Advanced Research on HIV Virus and Infection
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 11451 | Submission Open
Keywords: HIV; viral proteins; immunogenetics; pathogenesis
(This special issue belongs to the Section Molecular Immunology)
Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 11043 | Submission Open
Keywords: mass spectrometry; quantitative analysis; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments submission deadline 20 Dec 2025 | 5 articles | Viewed by 10685 | Submission Open
Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic
(This special issue belongs to the Section Molecular Neurobiology)
Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms
edited by and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 10444 | Submission Open
Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
In Honor of Elie Metchnikoff, a Nobel Prize Winner, Who Discovered Macrophages as Phagocyte Cells Involved in the Process of Innate Immunity
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 10359 | Submission Open
Keywords: macrophages; monocytes; phagocytes; fibroblast; cytokines; chronic disease; autoimmune disease; inflammatory disease; immune response; disease treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recombinant Proteins, Protein Folding and Drug Discovery submission deadline 20 Dec 2025 | 7 articles | Viewed by 10334 | Submission Open
Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics
(This special issue belongs to the Section Biochemistry)
Breast Cancer: From Pathophysiology to Novel Therapies
edited by Jennifer Sims-Mourtada
submission deadline 20 Dec 2025 | 7 articles | Viewed by 10207 | Submission Open
Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies
(This special issue belongs to the Section Molecular Oncology)
Biomarkers and Early Detection Strategies of Ovarian Tumors
edited by Lukasz Szafron
submission deadline 20 Dec 2025 | 6 articles | Viewed by 10175 | Submission Open
Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment
(This special issue belongs to the Section Molecular Oncology)
Updates on Synthetic and Natural Antioxidants submission deadline 20 Dec 2025 | 6 articles | Viewed by 10150 | Submission Open
Keywords: antioxidants; synthetic; natural compounds
(This special issue belongs to the Section Biochemistry)
Current Research on Bioactives from Natural Products submission deadline 20 Dec 2025 | 4 articles | Viewed by 9837 | Submission Open
Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapies in Skeletal Muscle Diseases
edited by Valeria Guglielmi
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9409 | Submission Open
Keywords: skeletal muscle; skeletal muscle diseases; pathogenesis; molecular mechanism; muscle degeneration; muscle regeneration; myokines; cell therapy; gene therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Immunity and Inflammation in Cardiovascular Diseases
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 8992 | Submission Open
Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 8491 | Submission Open
Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design
(This special issue belongs to the Section Molecular Oncology)
RNA Vaccines and Therapeutics: Challenges and Opportunities
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 8334 | Submission Open
Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing
(This special issue belongs to the Section Molecular Pharmacology)
Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition
edited by and Giulia Russo
submission deadline 20 Dec 2025 | 7 articles | Viewed by 8169 | Submission Open
Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
The Role of Enzymes in Metabolic Processes
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 8163 | Submission Open
Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Natural Products in Drug Discovery submission deadline 20 Dec 2025 | 6 articles | Viewed by 8056 | Submission Open
Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Primary and Secondary Bladder Disorders in Neurourology and Inflammatory Diseases submission deadline 20 Dec 2025 | 4 articles | Viewed by 8019 | Submission Open
Keywords: bladder ischemia; bladder pain syndrome; interstitial cystitis; irradiation cystitis; ketamine cystitis; microbiota; overactive bladder; underactive bladder; botulinum toxin for bladder disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 7896 | Submission Open
Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 7818 | Submission Open
Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking
(This special issue belongs to the Section Macromolecules)
Molecular Research in Infective Mycobacteria
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 7736 | Submission Open
Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry
(This special issue belongs to the Section Molecular Microbiology)
Genetic Engineering of Plants for Stress Tolerance, Second Edition
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 7557 | Submission Open
Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits
(This special issue belongs to the Section Molecular Plant Sciences)
Topoisomerase Inhibitors: Future Perspectives and Challenges
edited by and Mark Mitton-Fry
submission deadline 20 Dec 2025 | 3 articles | Viewed by 7473 | Submission Open
Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety
(This special issue belongs to the Section Molecular Pharmacology)
Nutrition as a Tool for Modulating Cellular Metabolism submission deadline 20 Dec 2025 | 2 articles | Viewed by 7409 | Submission Open
Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology
(This special issue belongs to the Section Biochemistry)
Innovations in Polymeric Materials: Exploring Advancements and Applications
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 7316 | Submission Open
Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment
(This special issue belongs to the Section Materials Science)
High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 7273 | Submission Open
Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight
(This special issue belongs to the Section Biochemistry)
Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 7177 | Submission Open
Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex
(This special issue belongs to the Section Biochemistry)
Genetic Research in Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 6967 | Submission Open
Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models
(This special issue belongs to the Section Molecular Neurobiology)
The Importance of Molecular Circadian Rhythms in Health and Disease submission deadline 20 Dec 2025 | 5 articles | Viewed by 6949 | Submission Open
Keywords: molecular clock; circadian dysfunction; health; chronotherapy; circadian rhythms
(This special issue belongs to the Section Molecular Biology)
Diabetes: Advances in Molecular Research submission deadline 20 Dec 2025 | 3 articles | Viewed by 6918 | Submission Open
Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6684 | Submission Open
Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Lymphatic Disorders: From Molecular Mechanisms to Therapies
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 6632 | Submission Open
Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeting Glioblastoma Metabolism submission deadline 20 Dec 2025 | 3 articles | Viewed by 6479 | Submission Open
Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation
(This special issue belongs to the Section Molecular Oncology)
The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 6105 | Submission Open
Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights into Redox Homeostasis and Oxidative Stress
edited by , Zoi Vasiliki Skaperda and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5825 | Submission Open
Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases
(This special issue belongs to the Section Molecular Pharmacology)
Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition) submission deadline 20 Dec 2025 | 4 articles | Viewed by 5744 | Submission Open
Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake
(This special issue belongs to the Section Molecular Plant Sciences)
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