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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chemical Elicitors and Microbial Metabolites: Synergistic Mechanisms in Plant Systemic Resistance Induction

edited by Heewan Kang

submission deadline 30 Aug 2025 | Viewed by 28 | Submission Open

Keywords: chemical elicitors; Bacillus spp.; microbial metabolites; amino acids; defense induction; resistance mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy

edited by

Dong Min Lee

submission deadline 30 Aug 2025 | Viewed by 28 | Submission Open

Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications

edited by

Maria Lisa Garavaglia

and Cristina Porta

submission deadline 30 Aug 2025 | Viewed by 25 | Submission Open

Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Teleost in Biomedical Research

edited by

Antonino Germanà

and

Marialuisa Aragona

submission deadline 31 Aug 2025 | 2 articles | Viewed by 6552 | Submission Open

Keywords: fish; teleost; experimental model; translational research; biomedicine; comparative studies

(This special issue belongs to the Section Molecular Biology)

Effect of Diet on Human Neurocognitive Function

edited by

Radosław Zajdel

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4673 | Submission Open

Keywords: cognition; cognitive impairment; dietary pattern; nutrients; nervous cells

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Therapeutic Targets and Approaches to Manage Inflammation: Disappointing Past, Current Efforts and Faint Hopes

edited by Natasha Irrera

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3678 | Submission Open

Keywords: inflammation; inflammatory pathways; resolution of inflammation; inflammasome; molecular pathways; anti-inflammatory response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3498 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bio-Nano Interactions—3rd Edition

edited by

Massimiliano Magro

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2020 | Submission Open

Keywords: nanoparticles; proteins; smart nanomaterial surfaces; selective protein binding; nanomaterials; abiotic material; biological systems; bio-inspired inorganic materials and DNA nanotechnologies

(This special issue belongs to the Section Molecular Nanoscience)

Chitosan Materials: Recent Advances in Modification, Properties and Application

edited by

Gabriela Dudek

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1986 | Submission Open

Keywords: chitosan materials; biomedical applications; agriculture and food industry; water treatment and environmental applications; nanotechnology and advanced materials

(This special issue belongs to the Section Macromolecules)

Inflammatory Bowel Disease: From Genetics to Treatment

edited by Dalin Li

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1906 | Submission Open

Keywords: genetic predisposition; inflammatory bowel disease; genome-wide association study Crohn's disease; ulcerative colitis; bowel disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mast Cell Disorders: From Molecular Mechanisms to Therapeutic Approaches

edited by Ehud Razin and

Sagi Tshori

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1281 | Submission Open

Keywords: mastocytosis; mast cell activation syndrome; mast cell disorders; theurapeutic approaches; molecular mechanisms; tumor neovascularization; inflammatory diseases; asthma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders

edited by

Kazuhito Toyooka

submission deadline 31 Aug 2025 | 1 articles | Viewed by 875 | Submission Open

Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’ s disease; Parkinson’ s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Reproductive Medicine

edited by Wei Chen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 638 | Submission Open

Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders

(This special issue belongs to the Section Molecular Biology)

Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases

edited by

Daniel P. Zalewski

submission deadline 31 Aug 2025 | Viewed by 634 | Submission Open

Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in Neuroscience and Neurodegenerative Disease Therapeutics

edited by

Sarmistha Mitra

submission deadline 31 Aug 2025 | Viewed by 632 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 31 Aug 2025 | 1 articles | Viewed by 611 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vitamin K in Disease Mechanisms and Therapy

edited by Maria Kokozidou

submission deadline 31 Aug 2025 | Viewed by 487 | Submission Open

Keywords: vitamins K; vitamins K-soluble proteins; vitamin K-dependent clotting factors; matrix Gla protein; calcification of blood vessels; vascular stiffness; cardiac output; stroke volume

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiological and Pathological Hypoxia: The Battle between the Protective and Deleterious Effects of Oxygen Deprivation

edited by

Michele Samaja

Michele Maffia

Rita Paroni

and Giacomo Strapazzon

submission deadline 31 Aug 2025 | Viewed by 434 | Submission Open

Keywords: physiological hypoxia; pathological hypoxia; hypoxia; signalling pathway; inflammation; oxygen transport

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Novel Food Packaging Materials: Properties, Molecular Mechanisms, and Advanced Applications

edited by

Di Wang

and

Qingjun Kong

submission deadline 31 Aug 2025 | 1 articles | Viewed by 428 | Submission Open

Keywords: food packaging; food materials; nano materials; degradable materials; edible materials; coating; shelf life; food preservation; postharvest control

(This special issue belongs to the Section Materials Science)

Cutting Edge Advances in Antitumor Properties of Natural Products

edited by

Francesca Giordano

and

Maria Luisa Panno

submission deadline 31 Aug 2025 | Viewed by 401 | Submission Open

Keywords: natural product; cancer; cell signaling; cell death and differentiation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

submission deadline 31 Aug 2025 | Viewed by 375 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 31 Aug 2025 | 1 articles | Viewed by 266 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 31 Aug 2025 | Viewed by 223 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Diagnosis and Treatment of Colorectal Cancer

edited by Steven T. Brower and Robert Pergolizzi

submission deadline 31 Aug 2025 | Viewed by 220 | Submission Open

Keywords: colorectal cancer; biomarkers; epigenetics; targeted therapy; chemoresistance; personalized cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Microbial Genomics in the Omics Era

edited by

Surajit De Mandal

submission deadline 31 Aug 2025 | Viewed by 204 | Submission Open

Keywords: microbe; bioinformatics; DNA; RNA; protein; sequencing; structure; omics

(This special issue belongs to the Section Molecular Microbiology)

Therapeutic Horizons of Oligosaccharides: Molecular Mechanisms and Therapeutic Potential

edited by

Abdelali Daddaoua

and

María Núñez-Núñez

submission deadline 31 Aug 2025 | 1 articles | Viewed by 186 | Submission Open

Keywords: oligosaccharides; bacterial infection; multidrug-resistant

(This special issue belongs to the Section Molecular Microbiology)

Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition

edited by

Jyotshna Kanungo

submission deadline 31 Aug 2025 | Viewed by 178 | Submission Open

Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Alzheimer’s Disease

edited by Sudip Dhakal

submission deadline 31 Aug 2025 | Viewed by 174 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Role of MicroRNAs in Health and Diseases

edited by

Roberto Madeddu

submission deadline 31 Aug 2025 | Viewed by 158 | Submission Open

Keywords: miRNA; cancer; biomarkers; function; miRNA target

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Translation Process, Molecular Mechanism, and Recognition Methods of Post-Translational Modifications of Proteins

edited by

Hao Lin

submission deadline 31 Aug 2025 | Viewed by 158 | Submission Open

Keywords: DNA replication; repair; and transcription; post-translational modifications; chromatin; acetylation; methylation; phosphorylation; ubiquitination and ubiquitin-like modifiers; histone modifications

(This special issue belongs to the Section Molecular Biology)

Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases

edited by

Mohammed Jakaria

and

Jason Cannon

submission deadline 31 Aug 2025 | Viewed by 151 | Submission Open

Keywords: neurotoxicity; cellular stress; neuronal cell death; ferroptosis; neurodegeneration; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Diverse Biomolecular Probes in the Development of Single-Molecule Biosensors

edited by

Kevin D. Belfield

and

Xiaohan Chen

submission deadline 31 Aug 2025 | Viewed by 150 | Submission Open

Keywords: biomolecular probes; single-molecule method; biosensors; diseases diagnosis; biomarkers; nanotechnology

(This special issue belongs to the Section Materials Science)

Plant Genomics and Genome Editing, 3rd Edition

edited by

Hikmet Budak

submission deadline 31 Aug 2025 | Viewed by 146 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

PD-L1 – PD1 Signaling Axis: From Mechanism to Therapeutics

edited by

Grazyna Kochan

and

David Escors

submission deadline 31 Aug 2025 | Viewed by 146 | Submission Open

Keywords: PD-L1/PD1 immune checkpoints; cancer; mechnistic insights and resistances; adaptive immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Acute Kidney Injury: Molecular Mechanism and Targeted Therapeutic Approaches

edited by

Bin Yang

submission deadline 31 Aug 2025 | Viewed by 144 | Submission Open

Keywords: kidney injury; repair; immunoresponse; biomarker; targeted therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 31 Aug 2025 | Viewed by 141 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cutting-Edge Innovations in Molecular and Nanoscale Engineering for Energy Applications

edited by

Mohammad R. Thalji

and

Farzaneh Mahmoudi

submission deadline 31 Aug 2025 | Viewed by 140 | Submission Open

Keywords: nanostructured electrode materials; energy storage; energy conversion; energy materials

(This special issue belongs to the Section Materials Science)

Molecular Research on Immune Response to Virus Infection and Vaccines

edited by

Giulia Matusali

submission deadline 31 Aug 2025 | Viewed by 137 | Submission Open

Keywords: immunogenicity; emerging pathogen vaccination; molecular and cellular determinants of vaccine responses in immunocompromised individuals; predictive markers of immune response; laboratory methods to dissect immune responses to infections and vaccinations

(This special issue belongs to the Section Molecular Immunology)

Neurodegenerative Disorders: Advances in Mechanisms, Models, and Therapeutics

edited by Craig Bennett

submission deadline 31 Aug 2025 | Viewed by 129 | Submission Open

Keywords: TDP-43; C9orf72; dipeptide repeat; proteotoxicity; cryptic exon exclusion; L-BMAA

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases

edited by Eisuke F. Sato

submission deadline 31 Aug 2025 | Viewed by 129 | Submission Open

Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals

edited by

Xiang Ma

and

Pengtao Ma

submission deadline 31 Aug 2025 | Viewed by 128 | Submission Open

Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Antioxidants: The Molecular Guardians Against Oxidative Stress

edited by

Karolina A. Wojtunik-Kulesza

submission deadline 31 Aug 2025 | Viewed by 125 | Submission Open

Keywords: antioxidant; free radical; oxidative stress; essential oils; secondary plant metabolites

(This special issue belongs to the Section Biochemistry)

Anticancer Agents of the Future: From Specific Molecular Targets to Individual Patient Profile

edited by

Zofia Mazerska

submission deadline 31 Aug 2025 | Viewed by 122 | Submission Open

Keywords: anticancer drug research; selective antitumor therapy; tumor cell molecular targets; tumor healthy cells selectivity; cancer cell metabolism; anticancer drug delivery; individual anticancer therapy; dual targeting anticancer therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Ferrocene-Based Molecular Research: Synthesis, Properties, and Applications

edited by

Mojca Čakić Semenčić

submission deadline 31 Aug 2025 | Viewed by 121 | Submission Open

Keywords: ferrocene; organometallic chemistry; bioorganometallic chemistry; ferrocene derivatives; synthesis; applications; bioconjugates

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Selected Papers from the 1st RNA and RNase International Meeting and Related Research

edited by

Ester Boix

submission deadline 31 Aug 2025 | Viewed by 120 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Biochemistry)

Molecular Research and Applications of Nanomaterials

edited by

Sónia Carabineiro

submission deadline 31 Aug 2025 | Viewed by 118 | Submission Open

Keywords: molecular research; application; functionality of nanomaterials; catalysis; environmental science

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Angiogenesis: Mechanisms, Signaling, and Therapeutic Horizons

edited by Edgar Delgado-Eckert

submission deadline 31 Aug 2025 | Viewed by 112 | Submission Open

Keywords: angiogenesis; VEGF; intracellular signaling in vascular biology; anti-angiogenic therapy for cancer; artery disease; age-related macular degeneration

(This special issue belongs to the Section Molecular Biology)

Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges

edited by

Odília Queirós

and

Patrícia M. A. Silva

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents

(This special issue belongs to the Section Molecular Biology)

Glycoconjugates: From Structure to Therapeutic Application

edited by Rosana Ribić

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: glycoconjugates (glycoproteins and glycopeptides; glycolipids; proteoglycans); glyconanoparticles; carbohydrate-based therapeutics; glycomics; glycosylation; glycoengineering; glycobiology; synthesis of glycoconjugates; vaccine development; drug delivery; biomarkers; diagnostics; immunotherapy; regenerative medicine; therapeutic applications

(This special issue belongs to the Section Molecular Pharmacology)

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