Lipopolysaccharide in the Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 933
Special Issue Editors
Interests: LPS; function of tissue macrophages; mode of action of oral administration of LPS; cognitive dysfunction; reverse aging
Special Issues, Collections and Topics in MDPI journals
Interests: health maintenance by innate immunity; removal of senescent cells by macrophages; food-derived LPS; LPS effects on the host in intestinal bacteria and indigenous skin bacteria
Special Issue Information
Dear Colleagues,
LPS has potent immune-activating effects. Therefore, LPS has been widely used in research as a substance that easily induces inflammation, but the physiological role that LPS originally plays has not received much attention. However, LPS is ubiquitous in the environment and in the digestive tract. Therefore, the mucous membranes and skin of living individuals are permanently exposed to LPS. In other words, LPS is not toxic when administered to mucous membranes or skin. In fact, the oral administration of LPS has been shown to improve lifestyle-related diseases and lipid disorders, reduce the side-effects of anticancer drugs, improve cognitive functions, alleviate allergic symptoms, and prevent viral infections, without inducing inflammation, completely different from cases where LPS is administered intravascularly.
We hope to receive submissions about new discoveries related to the usefulness of LPS. On the other hand, papers that view LPS as merely a disease-aggravating factor or that focus solely on its inflammation-inducing effects are discouraged.
Dr. Gen-Ichiro Soma
Dr. Hiroyuki Inagawa
Guest Editors
Manuscript Submission Information
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Keywords
- usefulness of LPS
- oral and/or dermal administration of LPS
- lifestyle disease
- cognitive dysfunction
- allergy
- autoimmune disorder
- wound healing
- cancer
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