P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 39
Special Issue Editor
Interests: p53; cancers; tumor suppression; chemotherapy; transcriptomics; genomics; p53 gene family; transcriptional regulation; next-generation sequencing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
P53 is a key factor involved in protecting cells against genotoxic stresses. The P53 protein mainly acts by activating cell-death-related genes and pathways in order to respond to severe stress and irreparable DNA damage. Where the damage is not so severe, it transactivates the cell cycle as well as DNA-repair-related genes in order to repair damaged DNA and restore proper cell proliferation, thus avoiding tumour onset and progression.
However, many aggressive tumours are able to overcome, in mid-long times, cellular responses to drugs by inhibiting key pathways involved in cell protection and the cellular response to uncontrolled proliferation, such as the p53 network. A complete overview of the molecular alterations both in p53 protein expression and in the p53-related pathways (defined by coding genes as well as regulatory RNAs) involved in mechanisms such as cell cycle arrest, DNA repair, and cell death, above all, would help to design strategies to fight aggressive chemoresistant tumours.
This Special Issue aims at summarizing all the latest studies and discoveries in this field in order to give useful information to be used for pharmaceutical and therapeutic strategies in order to overcome and reverse chemoresistance in cancer therapy.
Dr. Mariano Francesco Caratozzolo
Guest Editor
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Keywords
- P53
- chemoresistant tumours
- drug design
- regulatory RNAs
- drugs targeting
- NGS
- transcriptional regulation
- molecular networks
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