Zebrafish Model for Neurological Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 199
Special Issue Editor
Interests: prion; prion-like proteins; synuclein; nervous system; zebrafish (Danio rerio)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The zebrafish (Danio rerio) has swiftly established itself as a powerful model in neurological research, owing to its unique blend of biological characteristics and experimental flexibility. Its high genetic homology with humans enables the use of comprehensive omics approaches—such as transcriptomics, proteomics, and lipidomics—to unravel key molecular mechanisms underpinning neural development and neurological disorders.
The optical transparency of zebrafish embryos, together with the compact size of their organs, makes them ideally suited for in vivo imaging and immunofluorescence applications. Their rapid neurodevelopment, combined with the availability of advanced genome editing tools such as CRISPR-Cas9, facilitates the generation of targeted mutants for investigating gene function within neural circuits and neurodegenerative processes.
A diverse array of validated behavioural assays further supports the functional analysis of cognitive, motor, social, and anxiety-related phenotypes. Crucially, in this era of increasingly sophisticated research tools and considering the growing demand for translationally relevant models, the zebrafish offers an unparalleled opportunity to drive forward our understanding of the nervous system. Its accessibility, versatility, and relevance position it as a key model organism for advancing neurological science.
This Special Issue welcomes original research articles and reviews that utilise zebrafish to investigate the nervous system, encompassing areas such as neurodevelopment, neurodegeneration, neuropharmacology, neurotoxicology, and behavioural neuroscience. We particularly encourage submissions that introduce novel methodologies or offer translational insights.
We look forward to hearing from you.
Kind regards,
Dr. Mattia Toni
Guest Editor
Manuscript Submission Information
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Keywords
- zebrafish
- Danio rerio
- brain
- nervous system
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