HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 49
Special Issue Editor
Interests: transcription; ncRNAs; miRNAs; HIV; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
More than 40 years since the discovery of Human Immunodeficiency Virus (HIV), the Acquired Immunodeficiency Syndrome (AIDS) remains a major global health challenge. HIV is characterized by its ability to persist in diverse cellular reservoirs and evade immune surveillance, which prevents curative therapies and the development of an efficient vaccine. This special issue aims to explore the intricate molecular and cellular mechanisms that govern HIV transcription, latency, and reactivation across different cell types, including CD4+ T cells, macrophages, dendritic cells, and other cellular reservoirs. Recent advances in single-cell transcriptomics and genome editing technologies have provided new insights into HIV dynamics across different cell types. These findings have significant implications for the design of novel latency-reversing agents, immune-based interventions, and potential curative strategies. By elucidating the complex regulatory networks governing HIV expression, this special issue aims to bridge gaps in our understanding of HIV persistence and reactivation, paving the way for improved therapeutic interventions against HIV/AIDS.
We invite researchers and experts to submit original research articles, reviews, and perspectives that address key aspects of HIV expression, including:
- Host transcription factors, chromatin modifications, and signaling pathways involved in HIV regulation
- Epigenetic control of viral latency and reactivation mechanisms
- The role of the cellular microenvironment in HIV persistence and immune evasion
- Interactions between viral proteins, host restriction factors, and immune responses
- Insights from single-cell transcriptomics and genome-editing technologies for HIV research
- Novel therapeutic strategies targeting HIV persistence and reactivation
This Special Issue is led by Dr. Rosemary Kiernan and assisted by our Topical Advisory Panel Member Charbel Akkawi (Institut de Génétique Humaine).
We especially welcome submissions from across disciplines to contribute to this timely collection.
Dr. Rosemary Kiernan
Guest Editor
Manuscript Submission Information
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Keywords
- hiv transcription
- latency
- reactivation
- host transcription factors
- chromatin modifications
- viral-host protein interactions
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