Mitochondria: Central Players in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 820
Special Issue Editors
Interests: mitochondria; mitochondrial dysfunction; oxidative phosphorylation; tumorigenesis; cancer therapy
Interests: cancer biology and therapy; angiogenesis/anti-angiogenesis; chemoprevention
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria, the energy centers of cells, are intrinsically involved in cancer development. Beyond energy production, they regulate vital processes such as cell death. In cancer, mitochondrial function is often disrupted, leading to metabolic shifts favoring increased glycolysis (the Warburg effect), the increased production of harmful reactive oxygen species (ROS), and resistance to programmed cell death (apoptosis). These alterations contribute significantly to cancer progression. The focus of this Special Issue will be on exploring the role of mitochondria in the progression of carcinogenesis and identifying novel potential therapeutic strategies for cancer treatment by targeting mitochondrial function.
Dr. Annamaria Piscazzi
Dr. Domenica Mangieri
Guest Editors
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Keywords
- mitochondria
- cancer
- tumorigenesis
- oxidative phosphorylation
- glycolysis
- Warburg effect
- reactive oxygen species (ROS)
- apoptosis
- mitochondrial dysfunction
- metabolic reprogram-ming
- cancer therapy
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