Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 619
Special Issue Editor
Interests: thoracic malignancies; lung cancer; immunotherapy; targeted therapy; biomarkers; resistance mechanisms; EGFR/ALK inhibitors; tumor microenvironment; combination therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The landscape of solid tumor care is rapidly evolving, with immunotherapy and tyrosine kinase inhibitors (TKIs) leading the charge in transforming treatment strategies. Immunotherapy harnesses the body's immune system to specifically target and destroy tumor cells, offering significant benefits in cancers previously deemed hard to treat. By stimulating immune responses through checkpoint inhibitors, monoclonal antibodies, and CAR-T cells, immunotherapy has shown promise in various malignancies. Targeted TKIs can block specific enzymes or receptors responsible for tumor growth, providing a more precise, less toxic alternative to traditional chemotherapy. These inhibitors have revolutionized the management of cancers.
Immunotherapy and TKIs hold the potential to further improve patient outcomes, reducing recurrence and enhancing survival rates.
For this Special Issue, we invite researchers to contribute original research articles, reviews, and perspectives that examine both the fundamental and practical aspects of tumor–immune cell interactions, with a particular focus on the efficacy of immunotherapy and TKIs. As these therapies are already established in several clinical contexts, we welcome submissions that address emerging challenges and future directions in the field. Topics of interest include, but are not limited to, mechanisms of resistance to TKIs and immune checkpoint blockade, innovative combination therapies (such as TKIs with immunotherapy), biomarker discovery for patient stratification, and next-generation immunotherapies such as bispecific antibodies and neoantigen vaccines. We believe that this Special Issue will serve as a valuable building block in developing more advanced, effective, and personalized cancer therapies.
Dr. Walid Shalata
Guest Editor
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Keywords
- tyrosine kinase inhibitors
- immunotherapy
- monoclonal antibodies
- CAR-T cells
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