ijms-logo

Journal Browser

Journal Browser

Molecular Advances in Brain Plasticity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 806

Special Issue Editor


E-Mail Website
Guest Editor
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
Interests: brain development; neurogenesis; neurodevelopmental disease; dendritic spine; synapses; synaptic plasticity; learning and memory
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

 Dear Colleagues,

Research on brain plasticity has revealed the dynamic nature of the brain and its ability to reorganize and adjust in response to a variety of stimuli, among which developmental, environmental, and injury-related stimuli have become a hot topic in current research. Our knowledge of the molecular mechanisms underlying this process provides deeper insights into neurodevelopment, cognitive function regulation, and brain aging.

This Special Issue aims to bring together cutting-edge research on brain plasticity, with a particular focus on the molecular mechanisms at work. We invite contributions exploring molecular pathways, mechanisms, and therapeutic approaches to enhance our understanding of brain plasticity at the cellular and molecular levels in both physiological and pathological conditions. We aim to provide a comprehensive collection of studies that illuminate potential avenues for therapeutic interventions and brain repair strategies.

Dr. Beatrice Uguagliati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurophysiology
  • neurobiology
  • synapses
  • synaptic plasticity
  • microglia
  • astrocytes
  • dendritic spines
  • neurodevelopment
  • neurodevelopmental disease
  • learning and memory
  • neuropharmacology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

11 pages, 8227 KB  
Article
Extracellular Vesicles from Poor-Outcome Intracerebral Hemorrhage Patients Reveal Limited Reparative Potential in a Preclinical Model
by Fernando Laso-García, Nerea Díaz-Gamero, Rebeca Gallego-Ruiz, Laura Casado-Fernández, Exuperio Díez-Tejedor, Ángela Calzado-González, Javier Pozo-Novoa, Laura Otero-Ortega, María Alonso de Leciñana and María Gutiérrez-Fernández
Int. J. Mol. Sci. 2025, 26(21), 10648; https://doi.org/10.3390/ijms262110648 - 31 Oct 2025
Viewed by 483
Abstract
Extracellular vesicles (EVs) have emerged as potential therapeutic agents for neurological disorders. Their molecular cargo may reflect the clinical status of the donor and has been identified as a biomarker for the cellular damage and repair processes underlying intracerebral hemorrhage (ICH). It has [...] Read more.
Extracellular vesicles (EVs) have emerged as potential therapeutic agents for neurological disorders. Their molecular cargo may reflect the clinical status of the donor and has been identified as a biomarker for the cellular damage and repair processes underlying intracerebral hemorrhage (ICH). It has been shown that EVs from patients with favorable outcomes carry a distinct proteomic signature, compared to those from poor outcome patients, which may promote recovery in preclinical models of ICH. We investigated whether intravenously administered EVs isolated from patients with poor outcomes after ICH provide any benefit in a preclinical ICH model. No significant differences were observed in lesion volume between the placebo and treatment groups at 24 h, 72 h, or 28 days post-ICH. Functional assessments using the Rogers and tapered beam walking tests revealed no improvement in motor performance in the treatment group at 24 h, 72 h, 7 d, 14 d and 28 d. Histological analysis at 28 days showed no significant differences in immunofluorescence markers of myelin preservation (MOG, Olig-2), astroglial activation (GFAP), or angiogenesis (VEGF) between groups. In conclusion, EVs derived from patients with poor outcomes after ICH failed to promote functional recovery or modulate markers of injury and repair in a rat model, suggesting few endogenous repair mechanisms. Full article
(This article belongs to the Special Issue Molecular Advances in Brain Plasticity)
Show Figures

Graphical abstract

Back to TopTop