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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4408 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Parasitic Infection

edited by Marcin Wiśniewski and

Piotr Bąska

submission deadline 20 Oct 2026 | 4 articles | Viewed by 4400 | Submission Open

Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets

edited by Souleymane Abdoul-Azize

submission deadline 20 Oct 2026 | 3 articles | Viewed by 4335 | Submission Open

Keywords: small-molecule drugs; signal transduction; therapeutic targets; therapeutic resistance; oncogenic signaling; novel biomarkers; cancer therapy; cancer signaling pathways; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Metabolic Regulators of Bone Health

edited by

Akkouch Adil

submission deadline 20 Oct 2026 | 2 articles | Viewed by 4327 | Submission Open

Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 20 Oct 2026 | 5 articles | Viewed by 4159 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 Oct 2026 | 1 articles | Viewed by 4004 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—2nd Edition

edited by

Elisa Oltra

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3446 | Submission Open

Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomechanics and Molecular Research on Glioblastoma: 2nd Edition

edited by

Lorenzo Corsi

submission deadline 20 Oct 2026 | 3 articles | Viewed by 3166 | Submission Open

Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3137 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Oct 2026 | 4 articles | Viewed by 3029 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Immunity in Neurodegenerative Diseases: Systemic Immune Imbalance, Neuroinflammation, and Beyond—2nd Edition

edited by

Ivana Munitic

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2740 | Submission Open

Keywords: neurodegeneration; CNS immunosurveillance; neuroinflammation; neuroimmune axis; glia; T cells; phagocytosis; immunomodulation; autoimmunity; immunodeficiency

(This special issue belongs to the Section Molecular Neurobiology)

Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2689 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Orofacial Pain and Headache

edited by

Adriana Elena Bulboaca

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2612 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress in Plants, 2nd Edition

edited by

Xiujun Zhang

submission deadline 20 Oct 2026 | 4 articles | Viewed by 2530 | Submission Open

Keywords: abiotic stress; ROS; redox; antioxidants; phytohormones; ethylene; plant stress eco-physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Brain Plasticity

edited by

Beatrice Uguagliati

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2192 | Submission Open

Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond

edited by

Jian Zhang

and

Michael Deyholos

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1805 | Submission Open

Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Next-Generation Sequencing for Aging and Cancer Research

edited by Hyunsoo Kim

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1731 | Submission Open

Keywords: next-generation sequencing; aging; cancer genomics; cellular senescence; single-cell sequencing; epigenomics; transcriptomics; tumor evolution; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Advances in Plant Molecular Breeding and Molecular Diagnostics

edited by

Jiří Sedlák

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1581 | Submission Open

Keywords: plant molecular breeding; molecular diagnostics; pathogen detection; disease symptomatology; genetic resources; genetic diversity; phenology; genotype– phenotype integration; genome editing; omics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1568 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Role of Micronutrients in Cancer Prevention

edited by Jacek Baj

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1407 | Submission Open

Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications

edited by

Mihalj Poša

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1322 | Submission Open

Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy– entropy compensation; boundary surface; Langmuir isotherm; theoretical models

(This special issue belongs to the Section Biochemistry)

Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

edited by

Foteinos-Ioannis Dimitrakopoulos

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1320 | Submission Open

Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment

(This special issue belongs to the Section Molecular Oncology)

Skin Cancer: Molecular Drivers, Biomarkers, Non-Invasive Diagnostics and Therapeutic Strategies

edited by

Federico Venturi

Emi Dika

and Giulia Veronesi

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1283 | Submission Open

Keywords: melanoma; skin cancers; immunotherapy; targeted therapy; liquid biopsy; non-invasive diagnostics techniques; miRNA; genomic

(This special issue belongs to the Section Molecular Oncology)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1260 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibacterial and Antioxidant Effects of Plant-Sourced Compounds: 2nd Edition

edited by Johana Rondevaldova

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1161 | Submission Open

Keywords: antibacterial effect; antioxidants; medicinal plants; anti-infective agents; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells and Beyond

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Pharmacological Approaches in Inflammation, Aging, and Cardiovascular Diseases

edited by

Omer Dzemali

and

Era Gorica

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1152 | Submission Open

Keywords: inflammation; aging; cardiovascular diseases; approaches; translational research; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1115 | Submission Open

Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1065 | Submission Open

Keywords: functional polymers; polymer synthesis; structure– property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

Functional (Pharmaco) Genomics and Genetics in Atrial Fibrillation Associated with Sudden Cardiac Death Syndromes

edited by

Hector Barajas-Martinez

and

Anthony Ashton

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1005 | Submission Open

Keywords: atrial fibrillation; sudden cardiac death syndromes; channelopathies

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 20 Oct 2026 | 1 articles | Viewed by 977 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 20 Oct 2026 | Viewed by 923 | Submission Open

Keywords: cell adhesion; cell– cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Polymer Biocomposites: Synthesis, Applications and End-Life

edited by

Maria Chiara Mistretta

and

Manuela Ceraulo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: polymer biocomposites; biodegradable polymers; molecular design and synthesis; functional modifications; biodegradation

(This special issue belongs to the Section Materials Science)

Exploring Molecular Insights in Oral Health and Disease

edited by

Iulia-Ioana Stanescu-Spinu

and

Tudor Claudiu Spînu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 906 | Submission Open

Keywords: oral health; saliva; oral diseases; molecular insights; molecular targets; oral cavity physiology; wound healing; oral microbiome; oral biocompatibility; material interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 20 Oct 2026 | 1 articles | Viewed by 886 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms

edited by

Viviana Maresca

and

Alessia Postiglione

submission deadline 20 Oct 2026 | 1 articles | Viewed by 872 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Lung Cancer: Molecular Basis and Treatment Strategies

edited by

Hamada A.A. Noreldeen

submission deadline 20 Oct 2026 | Viewed by 840 | Submission Open

Keywords: adenocarcinoma; oncogenic drivers; precision oncology; signal transduction; tumor microenvironment; targeted therapy; resistance mechanisms; epigenetics; biomarker discovery; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Relationships Between Diabetic Retinal Neuropathies and Vascular Pathologies in Diabetic Retinopathy

edited by

Steven Abcouwer

and David A. Antonetti

submission deadline 20 Oct 2026 | 1 articles | Viewed by 708 | Submission Open

Keywords: retinal neurons; retinal vasculature; diabetic retinopathy; diabetic macular edema (DME); neurovascular coupling; neurovascular unit (NVU); diabetic vascular pathology; diabetic retinal neuropathy; diabetic retinal neurodegeneration; retinal thinning in diabetes; photoreceptor pathology in diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolomics as a Window into Human Disease Mechanisms

edited by

Paolo Iadarola

submission deadline 20 Oct 2026 | 1 articles | Viewed by 650 | Submission Open

Keywords: biomarker discovery; metabolomics; disease mechanisms

(This special issue belongs to the Section Molecular Informatics)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Oct 2026 | Viewed by 633 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Nephrotoxicity: From Environmental Toxins to Therapeutic Agents

edited by

Chih-Kang Chiang

submission deadline 20 Oct 2026 | 1 articles | Viewed by 631 | Submission Open

Keywords: pesticides; emerging pollutants; environmental toxicants; therapeutic strategies; nephrology; toxicology; public health

(This special issue belongs to the Section Molecular Toxicology)

Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives

edited by

Daniele Bottai

submission deadline 20 Oct 2026 | 1 articles | Viewed by 615 | Submission Open

Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Oct 2026 | Viewed by 582 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Crops: From Physiology to Breeding

edited by

Guang Chen

and Edyta Zdunek-Zastocka

submission deadline 20 Oct 2026 | 1 articles | Viewed by 538 | Submission Open

Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 20 Oct 2026 | Viewed by 496 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Cerebrovascular Diseases

edited by

Mariagiovanna Cantone

submission deadline 20 Oct 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: cerebrovascular diseases; stroke; vascular dementia; molecular mechanisms; biomarkers; omics; therapeutic targets; translational medicine

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Molecular Progression in Inorganic Synthesis

edited by

Suraj Kumar Pathak

submission deadline 20 Oct 2026 | Viewed by 404 | Submission Open

Keywords: inorganic synthesis; materials science; catalysis; energy materials; bioinorganic systems; organometallic compounds; supramolecular chemistry; molecular design

(This special issue belongs to the Section Materials Science)

Recent Advances in Rheumatic Diseases and Rheumatoid Arthritis

edited by

Ilaria Mormile

submission deadline 20 Oct 2026 | Viewed by 366 | Submission Open

Keywords: rheumatoid arthritis; systemic lupus erythematous; systemic sclerosis; Sjö gren’ s syndrome; psoriatic arthritis; rare autoimmune rheumatic diseases; vasculitis; biological therapies

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 2101-2150 on page 43 of 64.

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