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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1583 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Role of Micronutrients in Cancer Prevention

edited by Jacek Baj

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1416 | Submission Open

Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

edited by

Foteinos-Ioannis Dimitrakopoulos

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1353 | Submission Open

Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment

(This special issue belongs to the Section Molecular Oncology)

Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications

edited by

Mihalj Poša

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1332 | Submission Open

Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy– entropy compensation; boundary surface; Langmuir isotherm; theoretical models

(This special issue belongs to the Section Biochemistry)

Skin Cancer: Molecular Drivers, Biomarkers, Non-Invasive Diagnostics and Therapeutic Strategies

edited by

Federico Venturi

Emi Dika

and Giulia Veronesi

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1302 | Submission Open

Keywords: melanoma; skin cancers; immunotherapy; targeted therapy; liquid biopsy; non-invasive diagnostics techniques; miRNA; genomic

(This special issue belongs to the Section Molecular Oncology)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1273 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells and Beyond

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1191 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Antibacterial and Antioxidant Effects of Plant-Sourced Compounds: 2nd Edition

edited by Johana Rondevaldova

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: antibacterial effect; antioxidants; medicinal plants; anti-infective agents; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1180 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Pharmacological Approaches in Inflammation, Aging, and Cardiovascular Diseases

edited by

Omer Dzemali

and

Era Gorica

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1175 | Submission Open

Keywords: inflammation; aging; cardiovascular diseases; approaches; translational research; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1137 | Submission Open

Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: functional polymers; polymer synthesis; structure– property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

Functional (Pharmaco) Genomics and Genetics in Atrial Fibrillation Associated with Sudden Cardiac Death Syndromes

edited by

Hector Barajas-Martinez

and

Anthony Ashton

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1019 | Submission Open

Keywords: atrial fibrillation; sudden cardiac death syndromes; channelopathies

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 20 Oct 2026 | 1 articles | Viewed by 993 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 952 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Polymer Biocomposites: Synthesis, Applications and End-Life

edited by

Maria Chiara Mistretta

and

Manuela Ceraulo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 930 | Submission Open

Keywords: polymer biocomposites; biodegradable polymers; molecular design and synthesis; functional modifications; biodegradation

(This special issue belongs to the Section Materials Science)

Exploring Molecular Insights in Oral Health and Disease

edited by

Iulia-Ioana Stanescu-Spinu

and

Tudor Claudiu Spînu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 928 | Submission Open

Keywords: oral health; saliva; oral diseases; molecular insights; molecular targets; oral cavity physiology; wound healing; oral microbiome; oral biocompatibility; material interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 20 Oct 2026 | Viewed by 925 | Submission Open

Keywords: cell adhesion; cell– cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 20 Oct 2026 | 1 articles | Viewed by 899 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms

edited by

Viviana Maresca

and

Alessia Postiglione

submission deadline 20 Oct 2026 | 1 articles | Viewed by 885 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Lung Cancer: Molecular Basis and Treatment Strategies

edited by

Hamada A.A. Noreldeen

submission deadline 20 Oct 2026 | Viewed by 852 | Submission Open

Keywords: adenocarcinoma; oncogenic drivers; precision oncology; signal transduction; tumor microenvironment; targeted therapy; resistance mechanisms; epigenetics; biomarker discovery; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Relationships Between Diabetic Retinal Neuropathies and Vascular Pathologies in Diabetic Retinopathy

edited by

Steven Abcouwer

and David A. Antonetti

submission deadline 20 Oct 2026 | 1 articles | Viewed by 728 | Submission Open

Keywords: retinal neurons; retinal vasculature; diabetic retinopathy; diabetic macular edema (DME); neurovascular coupling; neurovascular unit (NVU); diabetic vascular pathology; diabetic retinal neuropathy; diabetic retinal neurodegeneration; retinal thinning in diabetes; photoreceptor pathology in diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolomics as a Window into Human Disease Mechanisms

edited by

Paolo Iadarola

submission deadline 20 Oct 2026 | 1 articles | Viewed by 667 | Submission Open

Keywords: biomarker discovery; metabolomics; disease mechanisms

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms of Nephrotoxicity: From Environmental Toxins to Therapeutic Agents

edited by

Chih-Kang Chiang

submission deadline 20 Oct 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: pesticides; emerging pollutants; environmental toxicants; therapeutic strategies; nephrology; toxicology; public health

(This special issue belongs to the Section Molecular Toxicology)

Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives

edited by

Daniele Bottai

submission deadline 20 Oct 2026 | 1 articles | Viewed by 645 | Submission Open

Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Oct 2026 | Viewed by 636 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Oct 2026 | Viewed by 585 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Crops: From Physiology to Breeding

edited by

Guang Chen

and Edyta Zdunek-Zastocka

submission deadline 20 Oct 2026 | 1 articles | Viewed by 549 | Submission Open

Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Cerebrovascular Diseases

edited by

Mariagiovanna Cantone

submission deadline 20 Oct 2026 | 1 articles | Viewed by 500 | Submission Open

Keywords: cerebrovascular diseases; stroke; vascular dementia; molecular mechanisms; biomarkers; omics; therapeutic targets; translational medicine

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 20 Oct 2026 | Viewed by 499 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms and Therapeutic Strategies for Oral Mucosal Diseases: From Radiotherapy-Induced Damage to Other Pathologies

edited by

Fernanda Gonçalves Salum

submission deadline 20 Oct 2026 | 1 articles | Viewed by 453 | Submission Open

Keywords: oral mucosal diseases; drug-induced oral lesions; radiotherapy- and chemotherapy-induced oral disorders; targeted therapy- and immunotherapy-induced stomatitis; oxidative stress and inflammation; oral microbiome and immunity; nanomedicine and biomaterials; photobiomodulation and photodynamic therapy; oral potentially malignant disorders; oral oncology; immune modulation; tissue regeneration and repair; translational research; investigational therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Molecular Progression in Inorganic Synthesis

edited by

Suraj Kumar Pathak

submission deadline 20 Oct 2026 | Viewed by 405 | Submission Open

Keywords: inorganic synthesis; materials science; catalysis; energy materials; bioinorganic systems; organometallic compounds; supramolecular chemistry; molecular design

(This special issue belongs to the Section Materials Science)

Recent Advances in Rheumatic Diseases and Rheumatoid Arthritis

edited by

Ilaria Mormile

submission deadline 20 Oct 2026 | Viewed by 370 | Submission Open

Keywords: rheumatoid arthritis; systemic lupus erythematous; systemic sclerosis; Sjö gren’ s syndrome; psoriatic arthritis; rare autoimmune rheumatic diseases; vasculitis; biological therapies

(This special issue belongs to the Section Molecular Immunology)

The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 20 Oct 2026 | Viewed by 367 | Submission Open

Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Pathophysiology of Nerve Regeneration

edited by Fabian Szepanowski and Mark Stettner

submission deadline 20 Oct 2026 | Viewed by 361 | Submission Open

Keywords: nerve injury; nerve inflammation; autoimmune neuropathies; immune-mediated neuropathies; polyneuropathies; peripheral neuroinflammation; nerve regeneration; Schwann cell; Schwann cell differentiation; repair Schwann cell

(This special issue belongs to the Section Molecular Neurobiology)

Amyloid-β: An Antimicrobial Defense Peptide

edited by

Anna Lia Asti

submission deadline 20 Oct 2026 | Viewed by 342 | Submission Open

Keywords: amyloid (Aß ); aggregation prone regions (ARPs); lipopolysaccharide (LPS); amphipathic molecules; LL-37 peptide; neurodegeneration; aggregation inhibition; Alzheimer's disease (AD)

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Cancer Pharmacotherapy

edited by

Yavuz Silig

submission deadline 20 Oct 2026 | 1 articles | Viewed by 341 | Submission Open

Keywords: cancer pharmacotherapy; molecular oncology; biomarker discovery; tumour microenvironment; signalling pathways; drug resistance; multi-omics; translational research; targeted therapy; preclinical models

(This special issue belongs to the Section Molecular Oncology)

Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition

edited by

Monique F. Stins

submission deadline 20 Oct 2026 | Viewed by 331 | Submission Open

Keywords: blood– brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’ s disease; Parkinson’ s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications

edited by

Marvin Xavierselvan

and

Steven Fiering

submission deadline 20 Oct 2026 | Viewed by 303 | Submission Open

Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies

(This special issue belongs to the Section Molecular Nanoscience)

Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor-Baran

submission deadline 20 Oct 2026 | Viewed by 300 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Insights into Allergic Asthma

edited by

Luisa Ricciardi

submission deadline 20 Oct 2026 | Viewed by 296 | Submission Open

Keywords: allergic asthma; molecular mechanisms; allergen exposure; T2 inflammation; inhaler treatment; biological treatment

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of SARS-CoV-2 Infection and Pathogenesis

edited by

Virginia Lotti

and

Erica Diani

submission deadline 20 Oct 2026 | Viewed by 285 | Submission Open

Keywords: SARS-CoV-2; molecular virology; host– pathogen interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Drug Discovery: Emerging Radiotracers and Small Molecule Inhibitors for Cancer and Neurological Disorders

edited by

Ramya Tokala

submission deadline 20 Oct 2026 | Viewed by 284 | Submission Open

Keywords: radiotracers; cytotoxic agents; drug discovery; molecular imaging; cancer therapy; neurological disorders; radiochemistry; medicinal chemistry; theranostics; drug development; molecular diagnostics

(This special issue belongs to the Section Molecular Pharmacology)

Bioactive Compounds: Innovative Technologies for Extraction, Synthesis, and Functional Evaluation

edited by

Parisa Abbasi Parizad

submission deadline 20 Oct 2026 | Viewed by 281 | Submission Open

Keywords: bioactive compounds; extraction; synthesis; functional evaluation; molecular aspects; mechanism of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer

edited by Radka S. Stoyanova

submission deadline 20 Oct 2026 | Viewed by 247 | Submission Open

Keywords: prostate cancer; molecular biomarkers; imaging; non-invasive biomarkers; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Epigenetic Elicitation of Dormant Microorganisms for Anti-Cancer Therapy

edited by

Komal Anjum

submission deadline 20 Oct 2026 | Viewed by 241 | Submission Open

Keywords: dormant microbes; epigenetic; bioactive molecules; anti-cancer therapy; biosynthetic pathways; bioactive secondary metabolites

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Immunotherapy for Cancer: From Molecular Basis to Novel Biomarkers and Therapeutic Targets—2nd Edition

edited by

Laura Conti

and

Valentina Audrito

submission deadline 20 Oct 2026 | Viewed by 217 | Submission Open

Keywords: tumor microenvironment; immune suppression; metabolic and molecular mechanisms of resistance to therapy; tumor immune escape; immunotherapy; immune checkpoint inhibitors; cancer vaccination; tumor-infiltrating cells; biomarkers; tumor antigens; cancer metabolism

(This special issue belongs to the Section Molecular Oncology)

Neurodegenerative Disease: From Molecular Basis to Therapy, 5th Edition

edited by

Claudia Ricci

submission deadline 20 Oct 2026 | Viewed by 215 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Sustainable Nanomaterials for Environmental Remediation

edited by

Odín Reyes−Vallejo

and

Francisco J. Cano

submission deadline 20 Oct 2026 | Viewed by 182 | Submission Open

Keywords: nanomaterials; environmental remediation; adsorption; photocatalysis; membrane separation; biomass-derived materials; sustainable and conventional synthesis; CO2 capture and conversion; water; air; and soil treatment; structure– property relationships

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Molecular Research in Bio-Based Polymeric Materials

edited by

Wanwitoo Wanmolee

submission deadline 20 Oct 2026 | Viewed by 174 | Submission Open

Keywords: bio-based polymers; lignin; cellulose; biopolymers; sustainable materials; green chemistry; biomass valorization; biocomposites; functional materials; sustainable packaging

(This special issue belongs to the Section Materials Science)

Displaying special issue 2101-2150 on page 43 of 65.

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