Molecular Mechanisms and Therapies for Melanoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 496
Special Issue Editor
Interests: melanoma; patient-derived melanoma models; adjuvant therapy in melanoma; microenvironment in melanoma; skin cancer; skin; UV; vitamin D and its derivatives; dermatoendocrinology; mitochondria; oxidative stress
Special Issue Information
Dear Colleagues,
Melanoma, representing only a minor percentage of all skin neoplasms, is responsible for the vast majority of deaths caused by cutaneous cancers. Moreover, the incidence of this aggressive malignancy has been dynamically increasing worldwide since 1975. Before 2011, advanced melanoma patients could expect a 5-year survival rate of 10%. Novel advanced therapies and their combinations, including immunotherapy with the immune checkpoint inhibitors CTLA-4 or PD-1, as well as targeted therapy with BRAF and MEK inhibitors, have become a critical breakthrough in the clinical landscape of melanoma treatment, as they resulted in an increase in the 5-year overall survival rate for metastatic melanoma to as much as 36%. Unfortunately, a substantial proportion of patients still either fail to respond to the therapy or will relapse over time, implying that melanoma remains a demanding clinical problem. Taking this into account, it seems necessary to continuously search for novel molecular targets and therapeutic solutions to overcome this fatal cancer. Advances in the field of molecular oncology and an increasingly precise understanding of the mechanisms and interactions within cancer nests have drawn attention to the critical role of the tumor microenvironment at all stages of tumorigenesis, establishing a new promising direction in cancer research, including melanoma.
This Special Issue provides insights into the molecular mechanisms of melanoma development, including the role of the tumor microenvironment, as well as recent advances in melanoma therapy, with a focus on novel potential therapeutic targets.
Dr. Anna Piotrowska
Guest Editor
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Keywords
- melanoma
- targeted therapy
- BRAF/MEK inhibitors
- immunotherapy
- anti-PD-1 and anti-CTLA-4 immunotherapy
- melanoma microenvironment
- cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs)
- MAPK (mitogen-activated protein kinase) signaling pathway
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