Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 415
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer cells continuously evolve survival strategies, enabling resistance to therapeutic drugs. This resistance remains a major challenge, limiting the efficacy of existing treatments. Oncogenic signaling pathways orchestrate various cellular and molecular processes, including survival, proliferation, apoptosis, metabolism, epigenetic modifications, and tumor suppressor regulation. Identifying and targeting key signaling pathways with optimal anticancer activity and minimal toxicity has emerged as a promising approach to overcoming this hurdle.
This Special Issue will cover in vitro and in vivo studies exploring advances in deciphering cancer signaling mechanisms underlying resistance to therapies and the role of novel drugs in modulating these signaling pathways to accelerate the discovery of new therapeutic targets.
In this Special Issue, original research articles and reviews on solid and hematological malignancies are welcome.
Dr. Souleymane Abdoul-Azize
Guest Editor
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Keywords
- small-molecule drugs
- signal transduction
- therapeutic targets
- therapeutic resistance
- oncogenic signaling
- novel biomarkers
- cancer therapy
- cancer signaling pathways
- immunotherapy
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