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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Synthetic Methodologies in Drug Development
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4377 | Submission Open
Keywords: organic chemistry; medicinal chemistry; catalysis; photo-catalysis; green chemistry; drug design; drug analysis; flow chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments
edited by and Anna Maria Ciaccio
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4323 | Submission Open
Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biofunctional Coatings for Medical Applications submission deadline 20 Sep 2025 | 4 articles | Viewed by 4295 | Submission Open
Keywords: biofunctional coatings; thin film deposition techniques; surface engineering; tissue engineering; materials’ doping and co-doping; medical applications
(This special issue belongs to the Section Materials Science)
TRP Channels for Pain, Itch and Inflammation Relief: 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 4163 | Submission Open
Keywords: TRP channels; “ thermoTRP” channels; neuropathic pain; inflammatory pain; cancer pain; pruritic skin iseases; itch; neurogenic inflammation; migraine
(This special issue belongs to the Section Molecular Immunology)
Molecular Genetics of Breast Cancer—Recent Progress
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4061 | Submission Open
Keywords: hereditary cancer; female breast cancer; male breast cancer; molecular oncology; cancer genetics; NGS of gene panels; transcriptomics; genetic predisposition to breast cancer; breast cancer risk; tumor profiling; predictive biomarkers; personalized treatment
(This special issue belongs to the Section Molecular Oncology)
Flow Cytometry: Applications and Challenges
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4050 | Submission Open
Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies
(This special issue belongs to the Section Molecular Biology)
New Trends in Research on Cerebral Ischemia
edited by Hideaki Imai
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3814 | Submission Open
Keywords: white matter damage; ischemia; axon regeneration; intervention; cell transplantation; exosome therapy; stem cells; myelin integrity; neurological disorders; neural repair; cognitive impairments
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Oxidative Stress and Antioxidants in Human Disease
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3801 | Submission Open
Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fish Immunology, 5th Edition submission deadline 20 Sep 2025 | 3 articles | Viewed by 3779 | Submission Open
Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation
(This special issue belongs to the Section Molecular Immunology)
Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles submission deadline 20 Sep 2025 | 2 articles | Viewed by 3778 | Submission Open
Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target
(This special issue belongs to the Section Molecular Biophysics)
Molecular Genetics and Breeding Mechanisms in Domestic Animals: 3rd Edition
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 3748 | Submission Open
Keywords: animal genetics; animal breeding; functional genomics; multiomics analysis; molecular immunity; interactions between microbe and host
(This special issue belongs to the Section Molecular Genetics and Genomics)
Role of Natural Products in Health and Diseases submission deadline 20 Sep 2025 | 2 articles | Viewed by 3679 | Submission Open
Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity
(This special issue belongs to the Section Molecular Pharmacology)
Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases
edited by Capercomorin S. Pitchumoni and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3456 | Submission Open
Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Perspectives in Nanomedicine
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3412 | Submission Open
Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies
(This special issue belongs to the Section Molecular Nanoscience)
TRP Channel, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3380 | Submission Open
Keywords: TRP; TRPAnkyrin; TRPCanonical; TRPMelastatin; TRPPolycystin; TRPVanilloid
(This special issue belongs to the Section Molecular Pharmacology)
Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3283 | Submission Open
Keywords: brain; brain cancer; depression; neurodegenerative disorders; natural compounds
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Polymers and Polysaccharides in Delivery Systems
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3265 | Submission Open
Keywords: polysaccharides; synthetic polymers; drug delivery systems; enzyme drugs; gene delivery; targeted release; controlled drug delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3193 | Submission Open
Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis
(This special issue belongs to the Section Molecular Nanoscience)
Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3168 | Submission Open
Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma
(This special issue belongs to the Section Molecular Oncology)
Targeted Radioligand Therapy and Immunotherapy for Cancer Treatment submission deadline 20 Sep 2025 | 1 articles | Viewed by 3148 | Submission Open
Keywords: targeted radioligand therapy; immunotherapy; receptor targeting; tumor-specific antigens; immune checkpoint inhibitors; radiosensitization; tumor microenvironment; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Small Molecule Drug Design and Research: 3rd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3124 | Submission Open
Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques
(This special issue belongs to the Section Molecular Pharmacology)
Technical Developments and Recent Applications of Cellular Molecular Imaging
edited by Hanae Sato
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3106 | Submission Open
Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging
(This special issue belongs to the Section Molecular Biology)
Recent Analysis and Applications of Comparative and Functional Genomic on Horticultural Plants: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3037 | Submission Open
Keywords: horticultural plants; gene family; comparative genomics; genome evolution; gene function; gene expression; database construction; tool development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Electrochemotherapy
edited by Jurij Novickij, and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3033 | Submission Open
Keywords: electrochemotherapy; drug delivery; pulsed electric fields; cancer; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach submission deadline 20 Sep 2025 | 2 articles | Viewed by 2967 | Submission Open
Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Autoimmune Diseases—2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 2918 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; biomarkers; pathogenic mechanisms
(This special issue belongs to the Section Molecular Immunology)
DNA and mRNA-Based Vaccines Against Infectious Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2881 | Submission Open
Keywords: mRNA vaccines; DNA vaccines; vaccine delivery; infectious disease; animal model
(This special issue belongs to the Section Molecular Immunology)
Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin
edited by Radoslaw Zajdel
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2847 | Submission Open
Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Wheat Genetics and Genomics: 3rd Edition
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 2761 | Submission Open
Keywords: wheat; genetics; molecular breeding; genome variation; multiomics
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Natural Compounds: Protecting Plants and Promoting Human Health, 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 2676 | Submission Open
Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Computational Methods for Studying the Effects of Radiation on Human Beings submission deadline 20 Sep 2025 | 2 articles | Viewed by 2629 | Submission Open
Keywords: DNA damage; biophysical models; DNA geometrical models; computational radiobiology; Monte Carlo simulations; ionizing radiation; heavy ions; DNA damage repair
(This special issue belongs to the Section Molecular Biophysics)
Chronic Liver Disease: From Pathophysiology to Treatment
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 2628 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); type 2 diabetes (T2D)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Discovery and Development Focusing on Natural Products submission deadline 20 Sep 2025 | 1 articles | Viewed by 2615 | Submission Open
Keywords: natural products; drug R& D; herbal medicine; gut microbiota; mechanism of action; therapeutic targets
(This special issue belongs to the Section Molecular Pharmacology)
Adapter CAR T Cells: From the Idea to the Clinic submission deadline 20 Sep 2025 | 1 articles | Viewed by 2541 | Submission Open
Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Quadruplex DNA and Its Ligands for Disease Treatment
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 2536 | Submission Open
Keywords: quadruplex; i-motif; transcriptional regulation; apoptosis; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokine Networks in Inflammatory Skin Diseases
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2491 | Submission Open
Keywords: chronic inflammatory skin diseases; immunopathogenesis; inflammatory pathways; cytokines; molecular targets; psoriasis; atopic dermatitis; hidradenitis suppurativa; urticaria; lichen planus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Compounds with Added Value from Marine Algae for Biomedical Applications submission deadline 20 Sep 2025 | 1 articles | Viewed by 2467 | Submission Open
Keywords: algae bioactive compounds; algal biotechnology for biomedical purposes; algal-derived biomedical materials; algal-based drug delivery systems; alginate; carrageenan; fucoidan; marine polysaccharides; marine peptides; marine polyphenols; marine antioxidants; marine bioactive compounds; marine glycosaminoglycans; marine biopolymers and biomaterials; marine lipids; marine-derived pharmaceuticals; marine-derived cosmeceuticals; marine-derived nutraceuticals; marine algae added-value products; marine drugs discovery; marine natural products; marine-derived anti-inflammatory agents; marine antimicrobial compounds; marine-derived anticancer agents; marine neuroprotective compounds; marine-derived anti-aging compounds; marine-based regenerative medicine; phycobiliproteins; seaweed-based tissue engineering materials; seaweed-derived bioactive molecules; seaweed extracts; seaweed-based wound healing materials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Oxidative Stress in Kidney Disease
edited by Stefanos Roumeliotis
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2462 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; hemodialysis; peritoneal dialysis; oxidative stress; pro-oxidants; inflammation; atherosclerosis; cardiovascular disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Strategies to Overcome Antibiotic Resistance in Carbapenem-Producing Bacteria submission deadline 20 Sep 2025 | 1 articles | Viewed by 2418 | Submission Open
Keywords: antibiotic resistance; antimicrobial agents; bacterial pathogens; carbapenemases; genomics; molecular mechanisms; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Mental Health and Disorders
edited by Eva Christina Schulte
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2413 | Submission Open
Keywords: molecular studies; mental health disorders; model systems; molecular epidemiology; omics   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified ChinesePRO Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Utilizing Induced Pluripotent Stem Cells and Cardiomyocytes: From Basic Research to Disease Modeling
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2396 | Submission Open
Keywords: induced pluripotent stem cells; cardiomyocytes; disease modeling; basic research; translational applications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2394 | Submission Open
Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Targets and Immunotherapy for Autoimmune Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2308 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells
(This special issue belongs to the Section Molecular Immunology)
Microbiota’s Role in Respiratory Disorders and Diseases
edited by and Mauro Carone
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2298 | Submission Open
Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Parvovirus
edited by Zahra Kadri
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2277 | Submission Open
Keywords: parvovirus structure; parvovirus replication; parvovirus proteome; cell signaling pathways; transcription; translation and post-translational modification; host restriction factor; host/parvovirus interaction; recombinant virus and VLP; immune evasion and/or activation; host tropism (cell type and species); new experimental models and approaches
(This special issue belongs to the Section Molecular Microbiology)
The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies
edited by Francesco Agostini
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2257 | Submission Open
Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights on Drug Discovery, Design, and Treatment
edited by Chih Kang Chiang
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2196 | Submission Open
Keywords: antibacterial drugs; antiviral drugs; antioxidant drugs; anti-inflammatory drugs; antibiotics; anticancer drugs; drug discovery; drug development; drug design; drug delivery; drug carriers; nanoparticles; molecular modeling; molecular mechanisms; crystallography; pharmacokinetics; molecular activity; inhibitors and antagonists
(This special issue belongs to the Section Molecular Pharmacology)
Emerging Heterocycles submission deadline 20 Sep 2025 | 1 articles | Viewed by 2190 | Submission Open
Keywords: synthesis; reactions; applications; biological activity; medicinal chemistry; natural products; alkaloids; new methodology
(This special issue belongs to the Section Biochemistry)
Rheumatoid Arthritis: Molecular Mechanisms and Immunotherapy
edited by Irena Manolova
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2188 | Submission Open
Keywords: rheumatoid arthritis; pathogenesis; innate immunity; adaptive immunity; inflammation; cytokines; autoantibodies; immunotherapy; clinical outcome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress and Cell Damage
edited by Haruhiko Inufusa, Koji Abe and Shigeru Hirano
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2153 | Submission Open
Keywords: oxidative stress; damages on cells; organs; body; prevention damages; parameter of oxidative stress; antioxidants
(This special issue belongs to the Section Molecular Biology)
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