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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Insights into Redox Homeostasis and Oxidative Stress
edited by , Zoi Vasiliki Skaperda and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5745 | Submission Open
Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases
(This special issue belongs to the Section Molecular Pharmacology)
Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition) submission deadline 20 Dec 2025 | 4 articles | Viewed by 5667 | Submission Open
Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake
(This special issue belongs to the Section Molecular Plant Sciences)
Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5495 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Synaptic Transmission and Plasticity
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5452 | Submission Open
Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Targeting Macrophages in Immunotherapy
edited by Vinod Nadella
submission deadline 20 Dec 2025 | 1 articles | Viewed by 5325 | Submission Open
Keywords: tumor-associated macrophages; tumor microenvironment; tumor immunology; carcinogenesis; macrophage repolarization; checkpoint inhibitor; immunotherapy; nanomaterials; metabolic reprogramming; epigenetics
(This special issue belongs to the Section Molecular Immunology)
Molecular Recognition and Biosensing
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 5259 | Submission Open
Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity
(This special issue belongs to the Section Biochemistry)
Molecular Research on Reproductive Physiology and Endocrinology
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 4972 | Submission Open
Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Insight into Extracellular Vesicles in Proliferative Diseases
edited by Sergio Esquivel-Ruiz
submission deadline 20 Dec 2025 | 2 articles | Viewed by 4940 | Submission Open
Keywords: proliferation; extracellular vesicles; intercellular communication; vesicle cargo; therapeutic applications; biomarkers
(This special issue belongs to the Section Molecular Immunology)
New Perspective on Inflammatory Diseases: Role of Natural Compounds submission deadline 20 Dec 2025 | 4 articles | Viewed by 4796 | Submission Open
Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biomarker Discovery and Validation for Precision Oncology
edited by
submission deadline 20 Dec 2025 | 5 articles | Viewed by 4796 | Submission Open
Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research
(This special issue belongs to the Section Molecular Oncology)
Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality submission deadline 20 Dec 2025 | 1 articles | Viewed by 4741 | Submission Open
Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 4582 | Submission Open
Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Multiple Sclerosis
edited by Yoshio Bando
submission deadline 20 Dec 2025 | 4 articles | Viewed by 4508 | Submission Open
Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Cytochrome P450 Mechanism and Reactivity
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4341 | Submission Open
Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition
(This special issue belongs to the Section Biochemistry)
Innovative Therapeutic Approaches in Neuropsychiatric Disorders
edited by Marta Pardo
submission deadline 20 Dec 2025 | 1 articles | Viewed by 4318 | Submission Open
Keywords: neuropsychiatric disorders; pharmacogenomics; pathophysiology; molecular treatment mechanisms; molecular targets for novel drug development; neurotransmitters; synaptic plasticity; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Neurological Disorders via Computational Neuroscience and Neural Networks
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 4000 | Submission Open
Keywords: neurological disorders; neuroimaging analysis; biomarker identification; computational neuroscience; machine learning; brain aging
(This special issue belongs to the Section Molecular Informatics)
Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment submission deadline 20 Dec 2025 | 3 articles | Viewed by 3967 | Submission Open
Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition) submission deadline 20 Dec 2025 | 2 articles | Viewed by 3846 | Submission Open
Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
Wnt/β-Catenin Signaling in Cancer submission deadline 20 Dec 2025 | 1 articles | Viewed by 3836 | Submission Open
Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 3800 | Submission Open
Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Link Between Nutrition and Obesity
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3762 | Submission Open
Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Research on Antifungal Resistance
edited by Anna Tomova
submission deadline 20 Dec 2025 | 4 articles | Viewed by 3702 | Submission Open
Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Nanomedicine in Gene Therapy and Immunotherapy
edited by and Ruixuan Gao
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3697 | Submission Open
Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Therapeutic Targets in Pancreatic Cancer: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 3679 | Submission Open
Keywords: pancreatic cancer; translational research; therapeutic targets and novel interventional strategies; mechanisms of anti-tumor reactions; biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Role of Neurons in Human Health and Disease—3rd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 3591 | Submission Open
Keywords: brain; nervous system; neurons; immune system; human health and disease
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3545 | Submission Open
Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Voltage-Gated Ion Channels and Human Diseases
edited by María A. Gandini
submission deadline 20 Dec 2025 | 5 articles | Viewed by 3531 | Submission Open
Keywords: channelopathies; voltage gated-ion channels; human diseases; mutations; calcium; sodium; potassium
(This special issue belongs to the Section Molecular Biophysics)
Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3525 | Submission Open
Keywords: neurodegenerative; ALS; motor neuron; genetics; molecular pathways; biomarkers; models; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Drug Treatment and Cancer Cell Drug Resistance submission deadline 20 Dec 2025 | 2 articles | Viewed by 3460 | Submission Open
Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Psoriasis: Molecular Research and Novel Therapy
edited by Tsen-Fang Tsai
submission deadline 20 Dec 2025 | 1 articles | Viewed by 3252 | Submission Open
Keywords: psoriasis; pathogenesis; treatment; biologics; novel therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biochemistry and Molecular Biology of Coronaviruses
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3151 | Submission Open
Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions
(This special issue belongs to the Section Molecular Microbiology)
Pathophysiology and Treatment of Alzheimer's Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 3123 | Submission Open
Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Allergic Diseases: Molecular Insights into Immunotherapy
edited by Stefania Nicola
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3063 | Submission Open
Keywords: component resolved diagnosis; allergen immunotherapy; molecular diagnostic; basophil activation test; anaphylaxis; allergy diagnosis; in vitro tests; in vivo tests; skin prick test
(This special issue belongs to the Section Molecular Immunology)
Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer
edited by Spyridon Siakavellas and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3056 | Submission Open
Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3054 | Submission Open
Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Data Science in Cancer Genomics and Precision Medicine: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 2977 | Submission Open
Keywords: cancer genomics; big data; tumor immunology; translational oncology; precision medicine; next-generation sequencing; omics; cancer genomic datasets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 2945 | Submission Open
Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Power Up Plant Genetic Research with Genomic Data: 3rd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 2936 | Submission Open
Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity
(This special issue belongs to the Section Molecular Genetics and Genomics)
From Nature to Medicine: Exploring Natural Products for New Therapies
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2919 | Submission Open
Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate
(This special issue belongs to the Section Molecular Pharmacology)
Systemic Sclerosis: New Insight into Pathogenesis, Molecular and Immune Mechanisms
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2859 | Submission Open
Keywords: systemic sclerosis; autoimmunity; inflammation; fibrosis; pathophysiology and treatment; profibrotic signaling; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2692 | Submission Open
Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies
edited by Reggiani Vilela Gonçalves and Rômulo Dias Novaes
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2583 | Submission Open
Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; remodeling; molecular pathways; apoptotic alterations; diabetes; tissue repair  
(This special issue belongs to the Section Biochemistry)
Molecular Advances in Veterinary Science
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2566 | Submission Open
Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics
(This special issue belongs to the Section Molecular Toxicology)
Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2564 | Submission Open
Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Latest Reviews in Molecular Plant Science 2025
edited by and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2394 | Submission Open
Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Secondary Metabolites in Plants
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 2206 | Submission Open
Keywords: specialized metabolites; biosynthesis pathways; pharmacological applications; medicinal plants; plant stress resistance; abiotic and biotic elicitors; chemometric analysis; plant biotechnology; therapeutic potential; plant signaling and communication
(This special issue belongs to the Section Molecular Plant Sciences)
Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers
edited by Ilias P. Nikas, and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2202 | Submission Open
Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning  
(This special issue belongs to the Section Molecular Oncology)
Phytochemicals of Natural Products: Source, Analysis, and Bioactivities
edited by , Chi-I Chang and Chi-Chien Lin
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2202 | Submission Open
Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Thyroid Hormone in Health and Disease
edited by Sandra Incerpi and Jens Z. Pedersen
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2184 | Submission Open
Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Diseases in Humans and Animals: From Emergence to Translational Medicine
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2170 | Submission Open
Keywords: animal diseases; human diseases; viruses; bacteria; translational medicine; environment; zoonosis; One Health; disease models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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