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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Recent Research on Natural Compounds: From Biosynthesis to Application

edited by

Nitin Mantri

submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open

Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery

(This special issue belongs to the Section Biochemistry)

Emerging Roles of the Gut-Brain Axis (GBA) in Health and Disease

edited by Vinata Vedam-Mai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 54 | Submission Open

Keywords: gut– brain axis; gut microbiota; brain function; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Role of DNA Methylation Signatures in Genetic Disorders

edited by

Jair Tenorio-Castano

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: DNA methylation; genetic disorders; episignature; genomic medicine; differentially methylated regions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Product-Inspired Anticancer Drug Development

edited by

Erzsébet Mernyák

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Product Therapies in Cancer

edited by

Domenica Mangieri

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: natural compounds; phytochemicals; flavonoids; alkaloids; metastasis; epithelial– mesenchymal transition; cancer cell invasion; cell cycle; programmed cell death; signaling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Aspects of Viral Pathogenesis: From Infection to Host Response

edited by

Quang Duy Trinh

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: viruses; viral pathogenesis; virus– host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation

(This special issue belongs to the Section Molecular Microbiology)

Interstitial Lung Diseases: From Molecular Pathology to New Treatments

edited by

Yasuhiko Koga

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: interstitial lung diseases (ILDs); therapeutic strategies; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Approach to Uncovering Signalling and Gene Regulation in Plants

edited by Xiang Li and Jingchun Shi

submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open

Keywords: omics; plant signalling; gene regulation; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Cell Signaling Targets and Mechanism for Effective Individualized Therapies

edited by Kazuyuki Matsushita

submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open

Keywords: novel cell signaling targets; individualized therapies; addiction signal pathway; diagnosis and treatment; cancer; neurodegenerative diseases; cell development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition

edited by

Dong-Sung Lee

submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open

Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms in Cardiovascular Disease Progression

edited by Ying-Hsi Lin

submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open

Keywords: cardiovascular disease progression; molecular mechanisms; inflammation; signal transduction; transcriptional and epigenetic regulation; mitochondrial dysfunction; sarcomeric remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Linked to Exercise

edited by Igor Zubrzycki

submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open

Keywords: molecular mechanisms; exercise adaptations; translational health

(This special issue belongs to the Section Molecular Biology)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure– activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Lectins: Structural Diversity, Molecular Recognition and Emerging Applications

edited by

Patrícia Maria Guedes Paiva

submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open

Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications

(This special issue belongs to the Section Biochemistry)

Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases

edited by

Mizanur Rahman

submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open

Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin

(This special issue belongs to the Section Molecular Immunology)

Advances in Fluorescent Sensors

edited by

Levente Cseri

and

Ervin Kovács

submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open

Keywords: fluorescence probe; fluorescent nanomaterials; analyte recognition; fluorescence imaging; real-time monitoring; photoinduced electron transfer; Fö rster resonance energy transfer; genetically encoded indicators; sensor devices; fluorescence microscopy

(This special issue belongs to the Section Materials Science)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Nov 2025 | Viewed by 49 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Signal Transduction Pathways: From Molecular Mechanisms to Therapeutic Targets

edited by

Boratkó Anita

submission deadline 30 Nov 2025 | Viewed by 49 | Submission Open

Keywords: signal transduction; molecular mechanism; cell signaling; disease pathways; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Molecular Pathology and Treatment of Oral Diseases

edited by

Paolo Boffano

submission deadline 30 Nov 2025 | Viewed by 49 | Submission Open

Keywords: odontogenic tumor; odontogenic cyst; oral pathology; oral cancer; molecular

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Approaches to Musculoskeletal Disorders Using Natural Products

edited by

Jae-Hyun Kim

submission deadline 30 Nov 2025 | Viewed by 49 | Submission Open

Keywords: natural products; bone metabolism; sarcopenia; osteoporosis; herbal medicine; osteo-sarcopenic obesity; bone– muscle crosstalk; low-molecular-weight compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Viral Infections: Molecular, Cellular, and Systems Perspectives

edited by Arnaldo Caruso and

Francesca Caccuri

submission deadline 30 Nov 2025 | Viewed by 49 | Submission Open

Keywords: virus– host interaction; epidemiology; evolution; innate immunity; computational modeling

(This special issue belongs to the Section Molecular Microbiology)

Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition

edited by

Luís Belo

and

Márcia Carvalho

submission deadline 30 Nov 2025 | Viewed by 48 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; toxicity mechanisms; inflammation; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

T Cell Malignancies: Translating Basic Research into Better Therapy

edited by

Grzegorz Przybylski

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Plant Metabolites under Environmental Stress: Mechanisms, Responses and Adaptation Strategies

edited by

Alfosea-Simón Marina

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: omics; biosynthesis; defense; stress; adaptation; metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures

edited by Hedwig Sutterluety-Fall

submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open

Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases

edited by

Eiko Nakamaru-Ogiso

submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Microbial Adaptations to Marine Plastics

edited by

Matan Oren

submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open

Keywords: plastisphere; marine plastic debris; microbial colonization; biofilms; microbial adaptation; community assembly; quorum sesing; plastic biodegradation; biogeochemical cycling; antibiotic resistance genes; marine microbial ecology; metagenomics; microbe– plastic interactions; microbial succession

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights in Renal and Epithelial Physiology

edited by Pedro A. Jose

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance

(This special issue belongs to the Section Molecular Biology)

Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action

edited by

Tianfang Wang

submission deadline 30 Nov 2025 | Viewed by 40 | Submission Open

Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships

(This special issue belongs to the Section Molecular Biology)

Molecular Evolution and Genetic Diversity in Viruses

edited by

Jennifer H. Lun

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: viral mutation; recombination reassortment; viral genomics; quasispecies dynamics; antiviral resistance; viral phylogenetics; zoonotic transmission; genomic surveillance

(This special issue belongs to the Section Molecular Microbiology)

Progress in Prevention and Treatment of Cardiovascular Diseases and Arrhythmias

edited by

Narcis Tribulova

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: translational research; novel animal models; novel treatment targets; pleiotropic drugs; harnessing of molecular H

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure and Function of Subcellular Organelle and Protein-Membrane Systems

edited by

Chikara Sato

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton

(This special issue belongs to the Section Molecular Biophysics)

Monovalent Ion-Exchange Membranes for Various Applications

edited by Noor ul Afsar

submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open

Keywords: molecular design; ion-exchange membranes; membrane-based separations; energy and resource recovery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Strategy on Diagnosis and Treatment of Meningioma and Glioma

edited by

Giuseppe Lombardi

submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open

Keywords: meningiomas; gliomas; molecular characterization; biomarker discovery; targeted therapy; neuroimaging; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias

edited by Joan-Lluís Vives-Corrons

submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open

Keywords: anemia; red blood cell erythropoiesis; membranopathies ; erythro enzymopathies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Rhizospheric Microbial Interactions

edited by

Jelena Lozo

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Gynecologic Cancer, 2nd Edition

edited by

Alicja Forma

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: ovarian cancer; uterine cancer; cervical cancer; vaginal cancer; vulvar cancer

(This special issue belongs to the Section Molecular Oncology)

Host DNA Damage Responses in Virus Propagation and Human Disease

edited by Nimrat Chatterjee

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer

(This special issue belongs to the Section Molecular Microbiology)

Innovative Nano- and Microcarrier Systems for Targeted Delivery

edited by

Matteo Perra

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: drug delivery systems; nanocarriers; microcarriers; targeted delivery; controlled release; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Ocular Inflammation and Infection

edited by

Christine Fardeau

submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open

Keywords: ocular infections; uveitis; choroiditis; masquerade syndrome; pseudo-uveitis; intraocular lymphoma; retinal dystrophy; ocular inflammation; neuroinflammation; immunotherapy-induced uveitis; autoimmune eye diseases; sarcoidosis; OCT; indocyanine green angiography

(This special issue belongs to the Section Molecular Immunology)

Novel Molecular Pathways in Oncology, 3rd Edition

edited by

Giovanna Casili

submission deadline 1 Dec 2025 | 4 articles | Viewed by 3829 | Submission Open

Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer

(This special issue belongs to the Section Molecular Oncology)

The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential

edited by

Manuel Benedikt Graeber

submission deadline 1 Dec 2025 | Viewed by 345 | Submission Open

Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 1 Dec 2025 | Viewed by 139 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 4 Dec 2025 | 7 articles | Viewed by 26893 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biology of Oral Cancer

edited by Rafał Pęksa

submission deadline 10 Dec 2025 | 1 articles | Viewed by 543 | Submission Open

Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition)

edited by

Koichi Kato

and

Takayuki Uchihashi

submission deadline 10 Dec 2025 | Viewed by 51 | Submission Open

Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design

(This special issue belongs to the Section Molecular Biophysics)

Displaying special issue 2001-2050 on page 41 of 71.

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