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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 31 Aug 2025 | Viewed by 102 | Submission Open

Keywords: genetic diseases; genotype– phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Endocrinology of Pregnancy

edited by

Georgios Valsamakis

submission deadline 31 Aug 2025 | Viewed by 102 | Submission Open

Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research in Wearable Self Diagnostics: Against Microbiology Infection

edited by Suw Young Ly

submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open

Keywords: in vivo; in vitro; assay; molecule; skin; AI medical doctor; semiconductor; digital signal; unmanned diagnosis treatment

(This special issue belongs to the Section Molecular Microbiology)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Aug 2025 | Viewed by 92 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential

edited by Hélia Neves

submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open

Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application

(This special issue belongs to the Section Molecular Biology)

Biotransformation and Engineering of Fungals and Microalgae

edited by Alejandro Chamizo-Ampudia

submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Natural Products from Plants: Association with Human Health and Therapeutic Benefits

edited by

Andrey Marchev

and

Nikolina Mihaylova

submission deadline 31 Aug 2025 | Viewed by 85 | Submission Open

Keywords: botanical products; phytochemicals; bio/pharmacological compounds; cellular and molecular targets; molecular and physiological mechanism; human health; disease prevention and treatment; inflammatory diseases; age-related disorders; chronic and (auto)immune diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 31 Aug 2025 | Viewed by 84 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Advanced Research on Enzymes in Biocatalysis

edited by

Simona Varriale

Samuel De Visser

and

Salvatore Fusco

submission deadline 31 Aug 2025 | Viewed by 81 | Submission Open

Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses

(This special issue belongs to the Section Biochemistry)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viruses as Therapeutic Tools: Medical and Biotechnological Applications

edited by

Víctor Romanowski

submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open

Keywords: molecular virology; virus– host interactions; immunology; gene therapy vectors; vaccines; antivirals

(This special issue belongs to the Section Molecular Microbiology)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Microbiome-Immunity Crosstalk and Its Role in Health and Disease

edited by

Ana Isabel Beltrán-Velasco

and Sara Uceda

submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open

Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanism in Infertility

edited by

Antonio Simone Laganà

and Andrea Etrusco

submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open

Keywords: infertility; molecular mechanisms; reproductive biology; genomics; epigenetics; biomarkers; assisted reproductive technologies; transcriptomics; proteomics; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies

edited by

Mohammad Ejaz Ahmed

submission deadline 31 Aug 2025 | Viewed by 76 | Submission Open

Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 31 Aug 2025 | Viewed by 75 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Novel Mechanisms of Receptor Activation

edited by

Zong-Jie Cui

submission deadline 31 Aug 2025 | Viewed by 71 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Molecular Mechanism and Targeted Therapy of Lymphedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 31 Aug 2025 | Viewed by 69 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Diet to Health: Which Molecules or Chemicals Are at Work?

edited by Sara Baldelli

submission deadline 31 Aug 2025 | Viewed by 69 | Submission Open

Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 31 Aug 2025 | Viewed by 68 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli

submission deadline 31 Aug 2025 | Viewed by 68 | Submission Open

Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cervical Cancer and Its Therapy

edited by Ilaria Cuccu and

Violante Di Donato

submission deadline 31 Aug 2025 | Viewed by 67 | Submission Open

Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes

(This special issue belongs to the Section Molecular Oncology)

Environmental Influences on Cellular Responses

edited by

Marcus Krüger

submission deadline 31 Aug 2025 | Viewed by 67 | Submission Open

Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction

(This special issue belongs to the Section Molecular Biology)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 31 Aug 2025 | Viewed by 66 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers

edited by

Antonella Virgilio

Veronica Esposito

and

Aldo Galeone

submission deadline 31 Aug 2025 | Viewed by 65 | Submission Open

Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition

edited by

Hui Qiao

and Hongtuo Fu

submission deadline 31 Aug 2025 | Viewed by 64 | Submission Open

Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture

(This special issue belongs to the Section Molecular Biology)

Cell Biology and Biochemistry of Gynaecological Cancer: Pathways to Discovering Novel Treatments

edited by

Kenny Chitcholtan

submission deadline 31 Aug 2025 | Viewed by 64 | Submission Open

Keywords: gynaecological cancer; ovarian cancer; endometrial cancer; cervical cancer; cell biology; treatment; cell metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 31 Aug 2025 | Viewed by 63 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Polymeric Biomaterials

edited by

Diego Acevedo

submission deadline 31 Aug 2025 | Viewed by 63 | Submission Open

Keywords: biopolymers; biocomposites; nanomaterials; applications

(This special issue belongs to the Section Materials Science)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 31 Aug 2025 | Viewed by 62 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 31 Aug 2025 | Viewed by 58 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Molecular Techniques to Study Food Safety Challenges

edited by

María J. Andrade

and Micaela Álvarez

submission deadline 31 Aug 2025 | Viewed by 58 | Submission Open

Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures

(This special issue belongs to the Section Molecular Microbiology)

From Pathogenic Mechanisms to Therapy in Retinal Diseases

edited by

Nan-Kai Wang

and

Eugene Yu Chuan Kang

submission deadline 31 Aug 2025 | Viewed by 56 | Submission Open

Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 31 Aug 2025 | Viewed by 55 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

Cancer Progression and Therapeutic Resistance Mechanisms

edited by

Fabrizio Fontana

submission deadline 31 Aug 2025 | Viewed by 54 | Submission Open

Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds

(This special issue belongs to the Section Molecular Oncology)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 31 Aug 2025 | Viewed by 54 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 31 Aug 2025 | Viewed by 54 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Pharmacogenomics: The State of the Art and Future Perspectives

edited by

Satohiro Masuda

submission deadline 31 Aug 2025 | Viewed by 53 | Submission Open

Keywords: G-protein-coupled receptors; membrane transporters; drug-metabolizing enzyme; endocytosis receptors; companion diagnostic (CDx); data science in pharmacogenomics; precision medicine with pharmacogenomics; siRNA; microRNA; drug-induced organ injury; drug-induced adverse reactions

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Genetics and Genomics of Ruminants—Second Edition

edited by

Brad A. Freking

submission deadline 31 Aug 2025 | Viewed by 52 | Submission Open

Keywords: ruminant genomics; structural genomics; functional genomics; epigenomics; gene expression; genome sequencing; genome evolution; genome-wide association study; genomic selection; marker-assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 31 Aug 2025 | Viewed by 51 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Genetics and Genomics of Silkworm

edited by

Min-Jin Han

submission deadline 31 Aug 2025 | Viewed by 50 | Submission Open

Keywords: silkworm genome; gene identification; comparative genomics; silkworm domestication; population genetics; functional genomics; insect immunity; genetic manipulation; silkworm breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 31 Aug 2025 | Viewed by 50 | Submission Open

Keywords: gliomas tumor microenvironment immune

(This special issue belongs to the Section Molecular Oncology)

Biological and Molecular Aspects of Exercise Adaptation

edited by

Alessandra Modesti

submission deadline 31 Aug 2025 | Viewed by 49 | Submission Open

Keywords: exercise; redox homeostasis; metabolic state; biological; physiological

(This special issue belongs to the Section Molecular Biology)

New Advances in Plant Genetic Research

edited by Ming Chen

submission deadline 31 Aug 2025 | Viewed by 49 | Submission Open

Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science

(This special issue belongs to the Section Molecular Plant Sciences)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 31 Aug 2025 | Viewed by 48 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

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